Shree Dhanvantary Pharmaceutical Analysis and Research Center

Sūrat, India

Shree Dhanvantary Pharmaceutical Analysis and Research Center

Sūrat, India
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Akabari A.H.,C K Pithawalla Institute Of Pharmaceutical Science And Research | Suhagia B.N.,Dharmsinh Desai University | Saralai M.G.,C K Pithawalla Institute Of Pharmaceutical Science And Research | Sutariya V.A.,Shree Dhanvantary Pharmaceutical Analysis and Research Center
Eurasian Journal of Analytical Chemistry | Year: 2017

A sensitive, specific and stability-indicating reversed phase high performance liquid chromatography-diode array detection method was developed for the quantitative determination of fluvastatin sodium in the presence of its degradation products. The chromatographic separation was performed on a Phenomenex Luna C18 column (150 X 4.0 mm, 5μm) in isocratic mode using acetonitrile and 0.02M potassium phosphate buffer (50 + 50, v/v, pH 5.0 adjusted with potassium hydroxide) as the mobile phase at a flow rate of 1.0 ml/min. The quantification was performed with a photodiode array detector at 235nm based on peak area. The method showed good linearity over the concentration range of 5-40 μg/mL with a detection limit of 1.1μg/mL and quantification limit of 3.3μg/mL. The proposed LC method was used to investigate the kinetics of acidic and oxidative degradation of fluvastatin sodium. The acidic and oxidative degradation had shown an apparent first-order kinetics and rate constants were found to be 0.0191μg/mL/min and 0.0048μg/mL/min, respectively. © Authors.

Vaghani S.S.,Pharmaceutics R B Patel Mahila Pharmacy College Atkot | Patel S.G.,Pharmaceutics R B Patel Mahila Pharmacy College Atkot | Jivani R.R.,Pharmaceutics R B Patel Mahila Pharmacy College Atkot | Jivani N.P.,Pharmaceutics R B Patel Mahila Pharmacy College Atkot | And 2 more authors.
Pharmaceutical Development and Technology | Year: 2012

The current study involves the development of oral bioadhesive hydrophilic matrices of repaglinide and the optimization of their in vitro drug release and ex vivo bioadhesion. A simplex lattice design was employed to systematically optimize the drug delivery containing two polymers and a filler. The proportions of polyethylene oxide (PEO), microcrystalline cellulose (MCC) and lactose were varied to be fitted in simplex lattice design. Mucoadhesion (M), drug release at 2h (Q2) and drug release at 8h (Q8) were taken as responses. Response surface plots were drawn and the optimum formulation was selected by desirability function. The criteria for optimized formulation were set for mucoadhesion as maximum, Q2 as 20% and Q8 as 80%. The formulations were also checked for their swelling index and showed good swelling characteristic. In vitro drug release study was carried out using simulated gastric fluid (SGF) pH 1.2. The experimental values of M, Q2 and Q8 for check point batch were found to be 0.211N, 21.87% and 80.86% respectively. The release profile indicated anomalous (non-Fickian) transport mechanism. The optimized formulation was further checked for its compatibility with other excipients by studying FTIR and DSC studies and they indicated the absence of any significant chemical interaction within drug and excipients. © 2012 Informa Healthcare USA, Inc.

Mandade R.,Sn Institute Of Pharmacy | Sreenivas S.A.,Guru Nanak Institute of Pharmacy | Sakarkar D.M.,Sn Institute Of Pharmacy | Choudhury A.,Shree Dhanvantary Pharmaceutical Analysis and Research Center
African Journal of Pharmacy and Pharmacology | Year: 2011

Free radicals induce numerous diseases by lipid peroxidation, protein peroxidation and DNA damage. It has been reported that numerous plant extracts have antioxidant activities to scavenge free radicals. In the present study, the antioxidant properties of crude extract of Hibiscus rosasinensis were examined, using different in vitro analytical methodologies, such as total antioxidant activity determination by ferric thiocyanate, hydrogen peroxide scavenging, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS + radical cation) radical cation scavenging activity and superoxide anion radical scavenging by riboflavin-methionine-illuminate system. Butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and α-tocopherol were used as the reference antioxidant radical scavenger compounds. The crude extract inhibited 94.58% peroxidation of linoleic acid emulsion at 20 μg/ml concentration, while the standard antioxidants BHA, BHT and α-tocopherol indicated an inhibition of 93.75, 96.66 and 83.33% at 60 μg/ml concentration, respectively. The hydrogen peroxide radical, DPPH radical, ABTS + radical cation(s) and superoxide anion radical scavenging activities of crude extract were also compared to BHA, BHT and α-tocopherol as references antioxidant compounds. The present study shows that the crude extract is an effective natural antioxidant component. © 2011 Academic Journals.

Gadad A.K.,University of the West Indies | Cameotra S.S.,Chandigarh Institute of Microbial Technology | Badiger A.,Shree Dhanvantary Pharmaceutical Analysis and Research Center
European Journal of Medicinal Chemistry | Year: 2011

A series of 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]-thiadiazole derivatives 4(a-k) have been prepared by reaction of 2-amino-5-cyclopropyl-1,3, 4-thiadiazole and an appropriate phenacyl bromide. Further 5-bromo 5(a-k) and 5-thiocyanato 6(a-k) derivatives were synthesized in order to study the effect of these substituents on antitumor activity. Structures of these compounds were established by IR, 1H NMR, 13C NMR and Mass spectroscopy. Seven compounds were granted NSC code at National Cancer Institute (NCI), USA for anticancer activity at a single high dose (10 -5 M) in full NCI 60 cell panel. Among the compounds tested, 5-bromo-6-(4-chlorophenyl)-2- cyclopropylimidazo[2,1-b][1,3,4]thiadiazole 5b (NSC D-96022/1) was found to be the most active candidate of the series at five dose level screening with degree of selectivity toward Leukemic cancer cell line. © 2011 Elsevier Masson SAS. All rights reserved.

Deshmukh A.S.,Shree Dhanvantary Pharmacy College | Badiger A.M.,Shree Dhanvantary Pharmaceutical Analysis and Research Center | Muralikrishna K.S.,Shree Dhanvantary Pharmacy College
Carbohydrate Polymers | Year: 2012

Gum ghatti (Anogeissus latifolia) or Indian gum is a complex non-starch polysaccharide. It has been widely employed in food, pharmaceuticals, paper and other industries primarily due to its excellent emulsification and thickening property. Other applications of gum ghatti are inadequately investigated owing to lack of information on it. Researchers in the recent years have shown a great interest in exploring its molecular structure and functional properties. This article is aimed at discussing the structural features, functional properties and applications of gum ghatti with an emphasis on its pharmaceutical potential. © 2011 Elsevier Ltd. All rights reserved.

Badiger A.,Shree Dhanvantary Pharmaceutical Analysis and Research Center | Zambre A.,University of Missouri
Arabian Journal of Chemistry | Year: 2014

A series of 1-methyl-N-[(substituted-phenylmethylidene)-1H-benzimidazol-2-amines (4a-4g) were prepared via the formation of 1-methyl-1H-benzimidazol-2-amine (3), which was prepared by the cycloaddition of o-phenylenediamine (1) with cyanogen bromide in the presence of aqueous base followed by N-methylation with methyl iodide in the presence of anhydrous potassium carbonate in dry acetonitrile. Moreover, the four-membered β-lactam ring was introduced by the cycloaddition of 4a-4g and chloroacetyl chloride in the presence of triethylamine catalyst to give 3-chloro-1-(1-methyl-1H-benzimidazol-2-yl)-(4'-substituted)-phenylazetidin-2-one 5a-5g. A total of 14 compounds were synthesized and characterized by IR, 1H NMR, 13C NMR and Mass spectral technique, in addition they were evaluated for anti-bacterial and cytotoxic properties. Among the chemicals tested 4a, 4b, 5a, 5b, 5g exhibited good antibacterial activity and 5f, 5g shown good cytotoxic activity in vitro. © 2011.

Akbari B.V.,Shree Dhanvantary Pharmacy College | Akbari B.V.,Shree Dhanvantary Pharmaceutical Analysis and Research Center | Patel B.P.,Shree Dhanvantary Pharmacy College | Patel B.P.,Shree Dhanvantary Pharmaceutical Analysis and Research Center | And 6 more authors.
International Journal of PharmTech Research | Year: 2010

In the present work the attempt was made to prepare taste masked suspension of Itopride hydrochloride using a simple rapid and cost effective method like complexation with ion exchange resin for taste masking that may acceptable to the industries. Itopride hydrochloride is a novel prokinetic agent it is used in treatments of gastro esophageal reflux disease, it is a highly bitter drug and not suitable for pediatric patients hence taste masking of drug was required. In the present work an attempt has been made to mask the taste, by employing complexation with various ion-exchange resins like doshion P 542, Tulsion 344, Indion 234, Indion 204, Kyron T 114 and to formulate in to a suspension. The prepared suspensions were evaluated for taste, drug content, particle size, viscosity, sedimentation volume, drug release and accelerated stability studies. Among the various resins, Kyron T 114 was found mask the drug satisfactorily. The developed formulation was an additional advantage like simplification of manufacturing procedure and is economical. The drug release studies showed that complete drug was released within 20 min. The manufacturing procedure was found to be reproducible and formulations were stable after one month of accelerated stability studies.

Roy S.P.,Shree Dhanvantary Pharmacy College | Roy S.P.,Shree Dhanvantary Pharmaceutical Analysis and Research Center | Roy S.P.,Anna University | Gupta R.,Shree Dhanvantary Pharmacy College | And 3 more authors.
Journal of Chemical and Pharmaceutical Sciences | Year: 2013

Herbal medicines are widely used from their established traditional exploit for thousands of year. A number of herbal drugsshow promising hepatoprotective activities in acute and chronic liver damage. In the present paper five plants (Madhuca longifolia, Polyalthia longifolia, Delonix regia, Albizzia lebbeck, Tribulus terristoris,) are viewed for historical, morphological, phytochemical and pharmacological aspects.The plants described contain antioxidant principles that can explain and justify their use in traditional medicine in the past. Since the evidence supporting the use of botanicals to treat chronic liver disease is insufficient and only few of them are well standardized and free of potential serious side effects, most of these medications are not recommended outside clinical trials.

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