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Sujatha S.,M S Ramaiah Dental College And Hospital | Jalihal U.,M S Ramaiah Dental College And Hospital | Devi Y.,M S Ramaiah Dental College And Hospital | Rakesh N.,M S Ramaiah Dental College And Hospital | And 2 more authors.
Indian Journal of Gastroenterology | Year: 2016

Aims and Objectives: The aim of this study is to compare surface pH in various parts of the oral cavity between patients with gastroesophageal reflux disease (GERD) and healthy controls. Methods: Using a flat pH meter sensor, fixed electrode pen type digital pH meter, oral pH levels were assessed at different mucosal sites among 34 GERD patients and 32 healthy controls. Salivary flow rates and buffering capacity were also assessed in them. A thorough oral examination was performed to screen for any oral and dental changes. Result: A significantly lower pH of 6.65 ± 0.13 (mean ± SD) was found in the GERD group compared to control group 7.23 ± 0.12 (p < 0.05). Least pH was found in the floor of the mouth 6.594 ± 0.17 and highest in the lower labial mucosa among the GERD patients. Salivary flow rate and buffering capacity were low in these patients. Significant changes were noticed in the hard and soft tissues of the oral cavity among the GERD group. Conclusion: Oral mucosal pH is altered in GERD patients and may contribute to effects on the oral cavity. © 2016, Indian Society of Gastroenterology. Source


Reddy S.S.,MS Ramaiah Dental College and Hospital | Rakesh N.,MS Ramaiah Dental College and Hospital | Chauhan P.,Shree Bankey Bihari Dental College and Research Center | Sharma S.,MS Ramaiah Dental College and Hospital
Mycopathologia | Year: 2015

Mucormycosis is an acute necrotic fungal infection with a fulminant course. Earlier considered a rare entity, mucormycosis is being reported with increasing frequency in recent years, possibly due to the increase in immunocompromised population especially diabetic patients. We report three cases of rhinocerebral mucormycosis among poorly controlled diabetic patients. This article emphasizes the need for further awareness of this disease, early diagnosis, and treatment to counter this opportunistic infection. © 2015, Springer Science+Business Media Dordrecht. Source


Yadav S.,Kalka Dental College and Hospital | Tyagi S.,Kalka Dental College and Hospital | Kumar P.,Shree Bankey Bihari Dental College and Research Center | Puri N.,Kalka Dental College and Hospital
Journal of Natural Science, Biology and Medicine | Year: 2014

In literal terms myiasis is the invasion of the tissues and organs of human beings by fly larvae. This phenomenon is well documented in the skin, especially among animals and people in developed and developing countries. When the tissues of oral cavity are invaded by the parasitic larvae of flies, the condition is called as oral myiasis. With the paper we are presenting a case of 19-year-old female suffering from oral myiasis of upper lip and palate. The treatment consisted of manual removal of the larvae, surgical debridement of the wound and oral therapy with doxycycline used as a locally acting drug for faster and better recovery. Source


Chandra A.,Banaras Hindu University | Singh A.,Sardar Patel Institute of Dental and Medical science | Sebastian B.,MAHE Institute of Dental science and Hospital | Agnihotri A.,JKK Nataraja Dental College and Hospital | And 2 more authors.
Journal of Cancer Research and Therapeutics | Year: 2013

Aims: The study aimed to assess the diffused expression of p53 protein in patients with OSCC and its association with age at diagnosis (using 50 years as a cut point). Study Design: Ten normal oral mucosa and sixty OSCC lesions from age-distinct patient populations were immunohistochemically analyzed for the expression of p53 protein. Results: In OSCC cases, 31 out of total 60 cases (51.67%) showed positive expression for p53 protein and it was more common in older study group (56.67%) than in younger study group (46.67%) but the difference was not statistically significant. Moreover, there was also no significant difference in the p53 indices (percentage of p53 positive cells) between the two study groups (P = 0.827). Conclusion: The alteration rates were found to be slightly higher in older patients although not statistically significant. Source


Verma R.,Shree Bankey Bihari Dental College and Research Center | Singh A.,Sardar Patel Institute of Dental and Medical science | Jaiswal R.,Sardar Patel Institute of Dental and Medical science | Chandra A.,Banaras Hindu University | And 2 more authors.
Indian Journal of Pathology and Microbiology | Year: 2014

Aim: Studies reveal that invasive tumor front may be the best field for quantification of proliferative and apoptotic markers. The current study assessed the expression of Ki-67 antigen and p53 protein at invasive tumor front of oral squamous cell carcinoma (OSCC) and correlated the immunostaining with the histologic grades of malignancy. Materials and Methods: A total of 80 slides sample was prepared for the study, one each from ten normal oral mucosa cases and two each from 30 OSCC cases. The OSCC patients were biopsied along invasive tumor front, and samples were immunohistochemically analyzed for the expression of both Ki-67 antigen and p53 protein. Results: Of the total 30 OSCC cases, the expression of p53 was found positive in 20 cases (66.6%), while Ki-67 expression was found positive in 21 cases (70%). All the cases in the control group were negative. A higher p53 and Ki-67 expression were seen in OSCC group as compared to normal mucosa. On comparing the control group with various grades of OSCC a statistically significant result was obtained. Conclusion: Higher and statistically significant expression was noted for both p53 and Ki-67 antigen. The results emphasize the potential of Ki-67 and p53 as biomarkers of carcinogenesis in OSCC. Ki-67 expression was comparatively higher when compared with p53 except in poorly differentiated squamous cell carcinoma and signifies actively proliferating malignant cells at invasive tumor front. Source

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