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Balaji A.,Shree Balaji Dental College and Hospital | Balaji T.M.,Sri Ramachandra University | Rao S.R.,Sri Ramachandra University
Journal of Clinical and Diagnostic Research | Year: 2015

Context: The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine. Aim: This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth. Materials and Methods: Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit. Results: Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01). Conclusion: The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth. © Journal of Clinical and Diagnostic Research. All rights Reserved.


Anand N.,Shree Balaji Dental College and Hospital | Chandrasekaran S.C.,Shree Balaji Dental College and Hospital | Alam M.N.,Shree Balaji Dental College and Hospital | Shankar G.,Shree Balaji Dental College and Hospital
Biomedicine (India) | Year: 2014

Ozone, an energized form of oxygen is an unstable gas that gives nascent oxygen molecule and has been used in human medicine for more than 100 years. The two primary nutrients in life are oxygen and water then it becomes imperative to question why not treat infections/inflammatory conditions with a naturally occurring substance that is truly broad spectrum with no toxicity or side effects. Integrating ozone therapy in to periodontal treatment is truly a paradigm shift. Ozonated olive oil is an ideal delivery system with the capacity of releasing nascent oxygen in a sustained manner. This case series highlights the various applications of ozonated olive oil in the management of periodontal diseases.


Anand N.,Shree Balaji Dental College | Suresh M.,Shree Balaji Dental College | Chandra Sekaran S.C.,Shree Balaji Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Worldwide estimates of childhood obesity are as high as 43 million, and rates continue to increase each year. Childhood obesity is a growing problem in the present era and it causes serious consequences in the later years. In today's society, electronic media have been thoroughly integrated into the fabric of life, with television, video games, and computers being central to both work and play. While these media outlets can provide education and entertainment to children, many researches are concerned with the negative impact of electronic media on children. Objective: The current study aimed to evaluate the correlation, as to how oral hygiene and periodontal health were influenced by obesity and lifestyle factors, among pre-adolescents of ages of 9-12 years. Materials and Methods: This study was conducted in schools located around Velachery, Chennai, India. A total of 426 children of age group of 9-12 years were selected. Information on their socio-economic, dietary, oral health statuses and time spent in leisure activities were assessed by using a questionnaire, followed by BMI estimation and these variables were correlated with their oral hygiene statuses. Results: The prevalence of poor oral hygiene and poor dietary habits was observed in children who spent more time in watching television, playing videogames and using computer. Good oral hygiene was observed in children who had visited dentists in the past. Conclusion: There is a strong association of lifestyle factors with oral hygiene in pre-adolescent children. Sedentary lifestyle, with more leisure activities, has a negative impact on the oral health of children.


Anand N.,Shree Balaji Dental College and Hospital | Chandrasekaran S.C.,Shree Balaji Dental College and Hospital | Dembla G.,Shree Balaji Dental College and Hospital
Biomedicine (India) | Year: 2013

Background: There is a high prevalence of measures of both protein energy malnutrition and inflammation in patients with end-stage renal disease (ESRD) who are undergoing maintenance hemodialyis (MHD). These observations led to coinage of the term malnutrition inflammation complex syndrome (MICS). Periodontitis, a chronic inflammatory disease of supporting tissues forms a major component of this MICS. This study aims to estimate the adverse effect of periodontitis in maintenance hemodialysis patients by comparing the periodontal severity with malnutrition and inflammation. Materials and methods: Seventy five patients undergoing hemodialysis were enrolled in this current study. The study was conducted in Kamakshi Memorial Hospital and Tanker Foundation, Chennai. Periodontal status was determined with PI and PDI score. Nutritional and inflammatory markers affecting periodontal status were obtained using a 10 point Malnutrition Inflammation Score (MIS). Results: Fair to poor oral health status was found with 78.9% in gingivitis and 21.3% in periodontitis. The duration of the dialysis was found to be directly proportional to status of periodontal health in these hemodialysis patients. Poor nutritional status and elevated levels of inflammatory markers, found in this study population have an impact on the periodontal health. Conculsion: The results of the present study confirm that periodontal status is compromised in HD patients and is under further risk of deterioration due to poor nutritional status and elevated markers of inflammation.


Rajput N.S.,Shree Balaji Dental College and Hospital | Bhaskar J.,Shree Balaji Dental College and Hospital | Valiathan M.,Shree Balaji Dental College and Hospital | Chandrasekaran S.C.,Sree Balaji Dental College and Hospital | Nazish Alam M.,Shree Balaji Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2013

Dental implants are established alternatives for replacing missing teeth. Dental implants are artificial tooth root, positioned in the jaw bone, in order to sustain the replacement tooth or bridge. Recent advance in dental implant technology has made it more convenient, efficient and affordable for patients. In the anterior maxilla, esthetic demands not only require well-anchored implants but also sufficient soft and hard tissue in order to achieve natural looking result. Augmentation of the resorbed alveolar crest can be achieved, for example, with onlay bone grafts, membrane techniques, bone distraction and bone splitting. This report highlights the placement of implants in compromised alveolar ridges with good results. Implant was successfully restored and follow-up done for one year.


PubMed | Shree Balaji Dental College and Hospital
Type: Journal Article | Journal: Journal of Indian Society of Periodontology | Year: 2013

Vitamin D is crucial for a wide variety of organ systems; nevertheless, its deficiency is highly prevalent, present in 30-50% of the general population. Evidence has demonstrated that vitamin D deficiency may place subjects at risk for not only low mineral bone density/osteoporosis and osteopenia, but also infectious and chronic inflammatory diseases. Through its effect on bone and mineral metabolism, innate immunity, and several vitamin D receptor gene polymorphisms, vitamin D has been reported to be associated with the periodontal disease.


PubMed | Shree Balaji Dental College and Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2013

Dental implants are established alternatives for replacing missing teeth. Dental implants are artificial tooth root, positioned in the jaw bone, in order to sustain the replacement tooth or bridge. Recent advance in dental implant technology has made it more convenient, efficient and affordable for patients. In the anterior maxilla, esthetic demands not only require well-anchored implants but also sufficient soft and hard tissue in order to achieve natural looking result. Augmentation of the resorbed alveolar crest can be achieved, for example, with onlay bone grafts, membrane techniques, bone distraction and bone splitting. This report highlights the placement of implants in compromised alveolar ridges with good results. Implant was successfully restored and follow-up done for one year.


PubMed | Shree Balaji Dental College and Hospital and Sri Ramachandra University
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine.This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth.Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit.Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01).The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth.

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