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Tokyo, Japan

Showa University is a private university in Japan with campuses in Tokyo, Yamanashi. and Kanagawa Prefectures. What was to become today's Showa University was founded in 1928 as Showa Medical School ; it was renamed Showa Medical University in 1946 before becoming Showa University in 1964. It now shares one its buildings with the British School in Tokyo. It also has affiliated hospitals. Wikipedia.

Showa University, Gc Corporation and Honda Electronics Co. | Date: 2012-07-11

This invention is achieved to provide a water-flow ultrasonic oral-cavity cleaning device and a method for water-flow ultrasonic oral-cavity cleaning for surely and efficiently cleaning an oral cavity. In the water-flow ultrasonic oral-cavity cleaning device

Japan National Institute of Advanced Industrial Science, Technology, Showa University and ASUKA Electrical CO. | Date: 2012-09-18

[Problem] To provide an apparatus for measuring a sensory threshold at the time of application of a moving stimulus to a sole simply with high reproducibility and evaluating peripheral neuropathy originating in diabetes. [Solution] Provided are a foot pedestal

Itabe H.,Showa University
Journal of Clinical Biochemistry and Nutrition | Year: 2012

Oxidized low-density lipoprotein isiknown as an important factor in the development of atherosclerosis. The introduction of a sensitive procedure for the determination of oxidized low-density lipoprotein in human circulating plasma using a monoclonal anti-body recognizing oxidized phosphatidylcholines has opened new fields of research based on in vivo oxidized low-density lipo-protein. The plasma oxidized low-density lipoprotein levels are significantly elevated in patients with acute myocardial infarction, cerebral infarction or chronic renal failure accompanied by hemo-dialysis. It was found that the plasma oxidized low-density lipoprotein level increased prior to aortic atherosclerotic lesion enlargement in apolipoprotein E-knockout mice. Recent studies have pointed out that oxidized low-density lipoprotein is trans-ferrable between vessel wall tissue and the circulation, so it is a reasonable hypothesis that plasma oxidized low-density lipo-protein levels reflect the oxidative status at local sites of athero-genesis. Oxidized low-density lipoprotein measurement has been applied to human gingival crevicular fluids, which can be collected easily and safely, and relatively high levels of oxidized low-density lipoprotein were shown to be present. These findings, together with recent clinical follow-up studies, suggest that oxidized low-density lipoprotein is a predictive biomarker of a variety of diseases related to oxidative stress. This review summarizes the current understanding of in vivo oxidized low-density lipoprotein and its potential significance as a biomarker of disease. ©2012 JCBN. Source

The effects of blue light emitter diode (LED) light exposure on retinal pigment epithelial cells (RPE cells) were examined to detect cellular damage or change and to clarify its mechanisms. The RPE cells were cultured and exposed by blue (470 nm) LED at 4.8 mW/cm(2). The cellular viability was determined by XTT assay and cellular injury was determined by the lactate dehydrogenase activity in medium. Intracellular reactive oxygen species (ROS) generation was determined by confocal laser microscope image analysis using dihydrorhodamine 123 and lipid peroxidation was determined by 4-hydroxy-2-nonenal protein-adducts immunofluorescent staining (HNE). At 24 h after 50 J/cm(2) exposures, cellular viability was significantly decreased to 74% and cellular injury was significantly increased to 365% of control. Immediately after the light exposure, ROS generation was significantly increased to 154%, 177%, and 395% of control and HNE intensity was increased to 211%, 359%, and 746% of control by 1, 10, and 50 J/cm(2), respectively. These results suggest, at least in part, that oxidative stress is an early step leading to cellular damage by blue LED exposure and cellular oxidative damage would be caused by the blue light exposure at even lower dose (1, 10 J/cm(2)). Source

The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated in a given direction to thereby produce a cell, a tissue or an organ through the further induction of the differentiation in the given direction. The composition comprises NELL-1 or a substance which can be altered so as to act as NELL-1 upon the differentiation. Also disclosed is a composition for maintaining a cell, a tissue or an organ produced by the induction of the differentiation.

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