Tokyo, Japan
Tokyo, Japan

Showa University is a private university in Japan with campuses in Tokyo, Yamanashi. and Kanagawa Prefectures. What was to become today's Showa University was founded in 1928 as Showa Medical School ; it was renamed Showa Medical University in 1946 before becoming Showa University in 1964. It now shares one its buildings with the British School in Tokyo. It also has affiliated hospitals. Wikipedia.

SEARCH FILTERS
Time filter
Source Type

Patent
Showa University, Honda Electronics Co. and GC Corporation | Date: 2014-05-28

This invention is achieved to provide a water-flow ultrasonic oral-cavity cleaning device and a method for water-flow ultrasonic oral-cavity cleaning for surely and efficiently cleaning an oral cavity. In the water-flow ultrasonic oral-cavity cleaning device 1, cleaning liquid W1 from a cleaning-liquid supplying device 2 is supplied into a transducer case 21 through a supply port 26. Ultrasonic waves S1 are propagated into the cleaning liquid W1 from an ultrasonic transducer 22 mounted in a transducer mounting part 23 inside the transducer case 21. The water-flow of the cleaning liquid W1 is collected at the apical-part inside the transducer case 21, and then emitted from the issue 27 into the oral cavity, wherein power supply of 100W or less is supplied to the ultrasonic transducer 22 of 50mm or less in diameter to propagate the ultrasonic waves S1 of 100kHz or more to 3MHz or less in frequency into the cleaning liquid W1.


Patent
Showa University, GC Corporation and Honda Electronics Co. | Date: 2015-04-08

Provided is a dental ultrasonic cleaning device that efficiently cleans teeth or dentures in an oral cavity using ultrasonic waves. A dental ultrasonic cleaning device 1 emits ultrasonic waves through a cleaning-liquid (W1) to the surface of a cleaning-target 26, ultrasonically cleaning it. An ultrasonic horn 24 propagates ultrasonic waves being generated by an ultrasonic-wave transducer 23 and emits them from the vibratory surface 25 provided at the tip-end of the horn 24. A liquid-reserving part 27 is provided, surrounding the vibratory surface 25 of the ultrasonic horn 24, which temporarily reserves the cleaning-liquid (W1) between the vibratory surface 25 and the cleaning-target 26. A cap-member 33 is provided at a certain interval opposite the liquid-reserving part 27. A cleaning-liquid discharge-tube inlet 35 is connected to a vacuum tube 36 within the cap-member 33, allowing the cleaning-liquid W1 used during the ultrasonic cleaning to be vacuumed from the oral cavity, into the cap-member 33, and then discharged through the vacuum tube 36.


A water jet spray nozzle has a flow path including, from the upstream side to the end of the flow path, a small-diameter portion having a small inside diameter, an expanded portion having a larger inside diameter than the small-diameter portion, and a jet orifice having a smaller inside diameter than the expanded portion. The water jet spray nozzle is configured such that water passing through the flow path with a pressure of 0.2 to 0.6 MPa is retained in the expanded portion to as to generate cavitation bubbles from the small-diameter portion to the expanded portion. The inside diameter of the small-diameter portion is 0.5 to 0.7 mm while the inside diameter of the jet orifice is 1 to 1.3 times larger than that of the small-diameter portion.


Patent
Tohoku University and Showa University | Date: 2014-02-26

Provided is a device for cleaning oral cavity and a method for cleaning oral cavity capable of well cleaning stains such as plaque, tartar, and the like even in a narrow portion such as a clearance between teeth, a clearance between implants, and the like. A cover 11 includes a jetting orifice 11a and a discharge orifice 11b and covers a tooth 1 by leaving a clearance between the tooth 1 and the cover 11 so that the clearance can hold water. A jetting unit 12 is mounted in the jetting orifice 11a and includes a flow path 24a communicating with the clearance between the tooth 1 and the cover 11. The jetting unit 12 is configured to generate cavitation bubbles by water flowing toward the clearance in the flow path 24a and jets the cavitation bubbles toward the inside of the cover 11. The flow path 24a includes a small diameter part 24b having a flow path diameter smaller than that on the upstream side and an enlarged part 24c having a flow path diameter larger than that of the small diameter part 24b. A discharge unit 13 discharges water in the clearance between the tooth 1 and the cover 11 from the discharge orifice 11b.


To provide a water jet spray nozzle, a water jet spray device, a cleaning method using the water jet, a gastrointestinal tract cleaning device, and a gastric wall cleaning device, which can improve cleaning capability relative to a water pressure and effectively remove gastric mucus without damaging gastric tissues, e.g., gastric mucosa when the present invention is used for cleaning a gastric wall. A water jet spray nozzle 11 has a flow path 11a including, from the upstream side to the end of the flow path, a small-diameter portion 21 having a small inside diameter, an expanded portion 22 having a larger inside diameter than the small-diameter portion 21, and a jet orifice 23 having a smaller inside diameter than the expanded portion 22. The water jet spray nozzle is configured such that water passing through the flow path 11a with a pressure of 0.2 to 0.6 MPa is retained in the expanded portion 22 so as to generate cavitation bubbles from the small-diameter portion 21 to the expanded portion 22. The inside diameter of the small-diameter portion 21 is 0.5 to 0.7 mm while the inside diameter of the jet orifice 23 is 1 to 1.3 times larger than that of the small-diameter portion 21.


Patent
Meiji Co. and Showa University | Date: 2014-07-09

The object of the present invention is to provide a food product for enhancing chewing ability having hardness, viscosity and so on suitable for the mouth of a small child from the age of one year to five years and eleven months, in particular a young child in the age of approximately one and one-half years who can utilize teeth for chewing after weaning. The food product for enhancing chewing ability of the present invention contains at least one type of main raw material selected from the flour group consisting of wheat flour, rice flour and starchy flour, and at least one type of secondary raw material selected from the group consisting of sorbitol and glycerol. This food product for enhancing chewing ability preferably has a breaking stress, breaking strain, brittleness stress and cohesiveness within predetermined ranges.


Patent
Japan National Institute of Advanced Industrial Science, Technology, Showa University, Asuka Electrical Co. and Takahashi | Date: 2015-07-29

[Problem] To provide an apparatus for measuring a sensory threshold at the time of application of a moving stimulus to a sole simply with high reproducibility and evaluating peripheral neuropathy originating in diabetes. [Solution] Provided are a foot pedestal 2, a probe 4 for applying a moving stimulus to a sole, and a probe driving structure 3, disposed on a base 1, for operating the probe 4 to separately move in directions intersecting at right angles along the sole. Also provided are an input switch 5 to be operated by a subject recognizing a moving stimulus, a drive controller 51 for controlling drive condition of the probe driving structure 3, and a main controller B for evaluating a measured sensory threshold. The main controller B preliminarily stores reference data of known sensory thresholds obtained by applying a moving stimulus to a sole of patients, and age correction factors calculated from standard values of sensory thresholds based on different ages of patients. The drive controller 51 controls drive condition of the probe driving structure 3 by using the reference data and the age correction factors to conduct a primary stimulus applying condition. Further, a secondary stimulus applying condition, and a tertiary stimulus applying condition are sequentially conducted to measure a sensory threshold.


Itabe H.,Showa University
Journal of Clinical Biochemistry and Nutrition | Year: 2012

Oxidized low-density lipoprotein isiknown as an important factor in the development of atherosclerosis. The introduction of a sensitive procedure for the determination of oxidized low-density lipoprotein in human circulating plasma using a monoclonal anti-body recognizing oxidized phosphatidylcholines has opened new fields of research based on in vivo oxidized low-density lipo-protein. The plasma oxidized low-density lipoprotein levels are significantly elevated in patients with acute myocardial infarction, cerebral infarction or chronic renal failure accompanied by hemo-dialysis. It was found that the plasma oxidized low-density lipoprotein level increased prior to aortic atherosclerotic lesion enlargement in apolipoprotein E-knockout mice. Recent studies have pointed out that oxidized low-density lipoprotein is trans-ferrable between vessel wall tissue and the circulation, so it is a reasonable hypothesis that plasma oxidized low-density lipo-protein levels reflect the oxidative status at local sites of athero-genesis. Oxidized low-density lipoprotein measurement has been applied to human gingival crevicular fluids, which can be collected easily and safely, and relatively high levels of oxidized low-density lipoprotein were shown to be present. These findings, together with recent clinical follow-up studies, suggest that oxidized low-density lipoprotein is a predictive biomarker of a variety of diseases related to oxidative stress. This review summarizes the current understanding of in vivo oxidized low-density lipoprotein and its potential significance as a biomarker of disease. ©2012 JCBN.


Provided is a dental ultrasonic cleaning device that efficiently cleans teeth or dentures in an oral cavity using ultrasonic waves. A dental ultrasonic cleaning device 1 emits ultrasonic waves through a cleaning-liquid (W1) to the surface of a cleaning-target 26, ultrasonically cleaning it. An ultrasonic born 24 propagates ultrasonic waves being generated by an ultrasonic-wave transducer 23 and emits them from the vibratory surface 25 provided at the tip-end of the horn 24. A liquid-reserving part 27 is provided, surrounding the vibratory surface 25 of the ultrasonic horn 24, which temporarily reserves the cleaning-liquid (W1) between the vibratory surface 25 and the cleaning-target 26. A cap-member 33 is provided at a certain interval opposite the liquid-reserving part 27. A cleaning-liquid discharge-tube inlet 35 is connected to a vacuum tube 36 within the cap-member 33, allowing the cleaning-liquid W1 used during the ultrasonic cleaning to be vacuumed from the oral cavity, into the cap-member 33, and then discharged through the vacuum tube 36.


The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated in a given direction to thereby produce a cell, a tissue or an organ through the further induction of the differentiation in the given direction. The composition comprises NELL-1 or a substance which can be altered so as to act as NELL-1 upon the differentiation. Also disclosed is a composition for maintaining a cell, a tissue or an organ produced by the induction of the differentiation.

Loading Showa University collaborators
Loading Showa University collaborators