Changhua, Taiwan
Changhua, Taiwan

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Shieh J.-I.,Asia University, Taiwan | Wu H.-H.,National Changhua University of Education | Huang K.-K.,Asia University, Taiwan | Huang K.-K.,Show Chwan Memorial Hospital
Knowledge-Based Systems | Year: 2010

Since National Health Insurance program formally went into effect in March 1995 in Taiwan, the residents enjoy high quality but relatively cheaper medical care compared with the most developed countries. To manage a hospital successfully, the important goals are to attract and then retain as many patients as possible by meeting potential demands of various kinds of the patients. This study first conducted the survey based on SERVQUAL model to identify seven major criteria from patients' or their families' viewpoints at Show Chwan Memorial Hospital in Changhua City, Taiwan. When the key criteria were found, the second survey developed for applying decision-making trial and evaluation laboratory (DEMATEL) method was issued to the hospital management by evaluating the importance of criteria and constructing the causal relations among the criteria. The results show that trusted medical staff with professional competence of health care is the most important criterion and mutually affects service personnel with good communication skills, service personnel with immediate problem-solving abilities, detailed description of the patient's condition by the medical doctor, and medical staff with professional abilities. Therefore, trainings on communication skills and problem-solving abilities would result in positive interaction for patients to trust medical staff. When the trusted medical staff provides professional competence of health care to patients, satisfaction would be increased. Crown Copyright © 2010.

Lee I.-K.,Kaohsiung Chang Gung Memorial Hospital | Lee I.-K.,Chang Gung University | Liu J.-W.,Kaohsiung Chang Gung Memorial Hospital | Liu J.-W.,Chang Gung University | Yang K.D.,Show Chwan Memorial Hospital
PLoS Neglected Tropical Diseases | Year: 2012

Background: A better description of the clinical and laboratory manifestations of fatal patients with dengue hemorrhagic fever (DHF) is important in alerting clinicians of severe dengue and improving management. Methods and Findings: Of 309 adults with DHF, 10 fatal patients and 299 survivors (controls) were retrospectively analyzed. Regarding causes of fatality, massive gastrointestinal (GI) bleeding was found in 4 patients, dengue shock syndrome (DSS) alone in 2; DSS/subarachnoid hemorrhage, Klebsiella pneumoniae meningitis/bacteremia, ventilator associated pneumonia, and massive GI bleeding/Enterococcus faecalis bacteremia each in one. Fatal patients were found to have significantly higher frequencies of early altered consciousness (≤24 h after hospitalization), hypothermia, GI bleeding/massive GI bleeding, DSS, concurrent bacteremia with/without shock, pulmonary edema, renal/hepatic failure, and subarachnoid hemorrhage. Among those experienced early altered consciousness, massive GI bleeding alone/with uremia/with E. faecalis bacteremia, and K. pneumoniae meningitis/bacteremia were each found in one patient. Significantly higher proportion of bandemia from initial (arrival) laboratory data in fatal patients as compared to controls, and higher proportion of pre-fatal leukocytosis and lower pre-fatal platelet count as compared to initial laboratory data of fatal patients were found. Massive GI bleeding (33.3%) and bacteremia (25%) were the major causes of pre-fatal leukocytosis in the deceased patients; 33.3% of the patients with pre-fatal profound thrombocytopenia (<20000/μL), and 50% of the patients with pre-fatal prothrombin time (PT) prolongation experienced massive GI bleeding. Conclusions: Our report highlights causes of fatality other than DSS in patients with severe dengue, and suggested hypothermia, leukocytosis and bandemia may be warning signs of severe dengue. Clinicians should be alert to the potential development of massive GI bleeding, particularly in patients with early altered consciousness, profound thrombocytopenia, prolonged PT and/or leukocytosis. Antibiotic(s) should be empirically used for patients at risk for bacteremia until it is proven otherwise, especially in those with early altered consciousness and leukocytosis. © 2012 Lee et al.

Lai G.-M.,Changhua Christian Hospital | Yan S.-L.,Show Chwan Memorial Hospital | Chang C.-S.,Changhua Christian Hospital | Tsai C.-Y.,Changhua Christian Hospital
World Journal of Gastroenterology | Year: 2013

Hepatitis B virus (HBV) reactivation is a well-recognized complication in patients with chronic HBV infection receiving cytotoxic or immunosuppressive chemotherapy. Imatinib mesylate and nilotinib are selective Bcr/Abl tyrosine kinase inhibitors, which are now widely used in the treatment of patients with chronic myeloid leukemia. Although HBV reactivation induced by imatinib mesylate has been reported, nilotinib-related HBV reactivation has not been reported in the English literature. We report here 2 cases of HBV reactivation in chronic myeloid leukemia patients receiving imatinib mesylate and a novel case of nilotinib related HBV reactivation. © 2013 Baishideng. All rights reserved.

Chen Y.-F.,Show Chwan Memorial Hospital | Chang J.S.,National Health Research Institute
Molecular Biology Reports | Year: 2012

Psoriasis is a chronic autoimmune skin disease with both environmental and genetic risk factors. Previous studies of the association between psoriasis and PTPN22 C1858T (rs2476601), a gain of function variant associated with a stronger inhibitory effect of T-lymphocytes, have produced inconsistent results. The purpose of the current study is to evaluate the association between PTPN22 C1858T and psoriasis using meta-analysis to: (1) have a sufficient sample size for detecting a weak association; and (2) to explore the heterogeneity between studies. A meta-analysis based on random-effects model was performed with ten studies (3,334 psoriasis cases and 5,753 controls) identified from a literature search. A non-significantly positive association between psoriasis and the PTPN22 T1858 was observed [summary allelic odds ratio (OR) = 1.15, 95 % confidence interval (CI): 1.00-1.33] and the association appears stronger among subjects with psoriatic arthritis (summary allelic OR = 1.23, 95 % CI: 1.00-1.52). A null association between PTPN22 T1858 and early-onset psoriasis was observed (summary allelic OR = 1.08, 95 % CI: 0.92-1.28). The current analysis showed a non-significantly positive association between psoriasis and the PTPN22 T1858 allele, and the association appeared stronger among subjects with psoriatic arthritis. Future studies of psoriasis should incorporate gene-environment interaction in the analysis and pay attention to the heterogeneity of psoriasis cases and bias associated with population stratification. © 2012 Springer Science+Business Media B.V.

Yeh C.-H.,Show Chwan Memorial Hospital | Yeh C.-H.,Hungkuang University | Yang J.-J.,Chung Shan Medical University | Yang M.-L.,Chung Shan Medical University | And 2 more authors.
Free Radical Biology and Medicine | Year: 2014

Acute lung injury (ALI) is a serious disease with unacceptably high mortality and morbidity rates. Up to now, no effective therapeutic strategy for ALI has been established. Rutin, quercetin-3-rhamnosyl glucoside, expresses a wide range of biological activities and pharmacological effects, such as anti-inflammatory, antihypertensive, anticarcinogenic, vasoprotective, and cardioprotective activities. Pretreatment with rutin inhibited not only histopathological changes in lung tissues but also infiltration of polymorphonuclear granulocytes into bronchoalveolar lavage fluid in lipopolysaccharide (LPS)-induced ALI. In addition, LPS-induced inflammatory responses, including increased secretion of proinflammatory cytokines and lipid peroxidation, were inhibited by rutin in a concentration-dependent manner. Furthermore, rutin suppressed phosphorylation of NF-κB and MAPK and degradation of IκB, an NF-κB inhibitor. Decreased activities of antioxidative enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase-1 caused by LPS were reversed by rutin. At the same time, we found that ALI amelioration by chelation of extracellular metal ions with rutin is more efficacious than with deferoxamine. These results indicate that the protective mechanism of rutin is through inhibition of MAPK-NF-κB activation and upregulation of antioxidative enzymes. © 2014 Elsevier Inc.

Lai H.-C.,Show Chwan Memorial Hospital
Pediatrics and Neonatology | Year: 2010

Gastrointestinal symptoms in Henoch-Schönlein purpura (HSP) are common and occur in about two-thirds of HSP patients. Surgical intervention is only required in a minority of cases. Intussusception is a rare complication and the most common surgical indication for HSP. We report a 3-year-old boy with HSP and clinical manifestations of palpable skin rash lasting for 4 days, fever for 3 days, intermittent abdominal cramping pain, and left ankle arthralgia lasting for several hours. Abdominal sonography revealed characteristic signs of intussusception including a doughnut sign and a pseudo-kidney sign in the right upper quadrant of the abdomen. After unsuccessful initial reduction by air enema, surgical reduction was arranged and manual reduction of the ileocecal intussusception without bowel resection was carried out. © 2010 Taiwan Pediatric Association.

Lai H.-C.,Show Chwan Memorial Hospital
Pediatrics and Neonatology | Year: 2010

Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract and represents a persistent remnant of the omphalomesenteric duct. The most common clinical presentation is intermittent and painless rectal bleeding, followed by intestinal obstruction. Intestinal obstruction due to Meckel's enterolith is rarely reported in children. We report a patient who presented with ileus secondary to fecalith impaction of Meckel's diverticulum, causing intestinal obstruction and diverticulitis. © 2010 Taiwan Pediatric Association.

A tGal-3BP-Fc fusion protein, a pharmaceutical composition, an isolated nucleic acid, a recombinant expression vector, and a method of inhibiting, decreasing, reducing, suppressing or limiting metastasis of cancer cells, and immunosuppressing or modulating phagocytosis and T-cell functions by using the same are disclosed herein. The tGal-3BP-Fc fusion protein comprises: a truncated Gal-3 binding protein with domain 4, and at least an Fc fragment of an immunoglobulin G. A pharmaceutical composition comprises the tGal-3BP-Fc or Fc-tGal-3BP fusion protein, and a pharmaceutically acceptable carrier. The method comprises a step of administrating the pharmaceutical composition to a subject in a therapeutically effective amount to inhibit, decrease, reduce, suppress or limit invasiveness and metastasis of cancer cells or to treat or modulate immune reactions of inflammatory diseases in the subject.

Show Chwan Memorial Hospital | Date: 2012-10-26

An X-ray imaging system for generating space transfer functions has an X-ray machine, a check board and a host. The X-ray machine has an X-ray camera and an image camera to respectively take an X-ray image and a reference image for a calibration pattern on the check board. The host has a controller electrically connected to the X-ray camera and the image camera to receive the X-ray image and the reference image. The controller generates parameters and space transfer functions according to the X-ray image and the reference image. The check board of the present invention is easy to be manufactured and is convenient to use in an X-ray imaging machine

Show Chwan Memorial Hospital | Date: 2013-03-15

An image enhancement method for improving color perception of colorblind viewers has an image input step, an image difference area analyzing step, an image color distribution adjusting step, and an image output step. In such method, a normal image and a colorblindness-simulative image are input and calculated to produce a colorblindness-optimized image. Color vision obtained by a colorblind person from the colorblindness-optimized image is substantially identical to that obtained by a person with normal color perception from the normal image.

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