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Chen Y.-Y.,Taipei City Psychiatric Center | Chen Y.-Y.,National Yang Ming University | Liao S.-F.,National Taiwan University | Teng P.-R.,Show Chwan Health Care System | And 4 more authors.
Social Psychiatry and Psychiatric Epidemiology

Purpose To examine if widespread media reporting of the suicide of a young female singer by charcoal burning increased suicide rates, and to examine whether the suicide induced a high risk of imitation suicide by this method among the young female group. Methods Poisson time series autoregression model was applied to examine the relative risk of overall and subgroup (age, gender and method) suicides during the 2-week period after the initiation of media reporting of the celebrity suicide. Results We found a significant increase (adjusted relative risk = 1.17, p = 0.04) in suicide deaths following media reporting of the celebrity suicide. The increase in suicides was particularly significant among female and young age groups. A marked increase in suicide by charcoal burning among females (adjusted relative risk = 1.44, p < 0.0001) was further observed. Conclusions Detailed description of a specific suicide method following celebrity suicides may induce extensive modeling effect, attracting wider age/sex groups to model the method. Our finding provides further support for restraining media reporting of celebrity suicide in suicide prevention. © Springer-Verlag 2010. Source

Yong S.-B.,Show Chwan Memorial Hospital | Wu C.-C.,Chang Bing Show Chwan Memorial Hospital | Tzeng Y.-C.,Show Chwan Health Care System | Yang K.D.,Chang Bing Show Chwan Memorial Hospital
Journal of Microbiology, Immunology and Infection

Background/Purpose: Environmental factors, different ages, and detection methods might affect the profiles of allergy sensitization and confound the diagnosis of allergic diseases. The purpose of this study was to investigate the different profiles of allergen sensitization in different ages, geographic areas, and detection methods. Methods: We analyzed the patients who received allergen sensitization tests by the automated microfluidic-based immunoassay system (BioIC) method at Show Chwan Memorial Hospital in Changhua City and at Chang Bing Show Chwan Hospital in Lu-gang from January 2011 to December 2011. Results were compared in different ages (3-6, 7-18, and ≥19), different geographic areas, and different detection methods and analyzed by Chi-square or Fisher exact test depending on sample size. Results: A total of 1145 patients were analyzed. The younger the age, the higher the food allergy sensitization rate is found (26.6% vs. 14.7% vs.11.1% p<0.001). The older the age, the higher the sensitization of Blomia tropicalis occurs (33.4% vs.15.1% p<0.001). The food allergen specific IgE directed against egg white was higher in coast area than city (15.4% vs. 3%, p=0.015). A higher rate of pollen sensitization was found in the detection by BioIC method (Bermuda grass, 17.2%; Timothy, 12.3%; ragweed, 5.7%). The sensitization rates of cockroach and cat dander were lower in both city and coast areas. Conclusion: Children have higher food allergy sensitization and adults have higher Blomia tropicalis sensitization. Children living in Changhua area no matter in city or coast area had a higher pollen sensitization rate but lower cat or dog dander sensitization rate. Apparently, age, environmental factors, and different methods significantly affect the allergen sensitization in the different areas of Taiwan. © 2012 . Source

Yong S.-B.,Show Chwan Memorial Hospital | Wu C.-C.,Show Chwan Memorial Hospital | Wang L.,Kaohsiung Chang Gung Memorial Hospital | Yang K.D.,Show Chwan Health Care System
Pediatrics and Neonatology

Perinatal nutrition has been implicated in the programming of diseases in children and adults. The prevalence of asthma has dramatically increased in the past few decades, particularly in children. This suggests that the perinatal environment, including maternal and infant diets, may be involved in the increase in the prevalence of asthma. Recent studies have demonstrated that certain maternal and infant diets have a protective or augmentative effect on the development of asthma. Maternal diets with higher vitamin D, vitamin E, or/and probiotics are related to asthma prevention. Infants with breast feeding for at least 4 months and/or complementary diets between 4 and 6 months may have regulatory effects on the prevention of asthma. In summary, diets may have epigenetic or immune regulatory effects on the promotion or prevention of asthma. This article analyzes recent reports on the potential mechanism and mechanism-driven early prevention of childhood asthma by modification of maternal and infant diets. Copyright © 2012, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved. Source

Hou P.-C.,Chang Gung University | Yu H.-R.,Chang Gung University | Kuo H.-C.,Chang Gung University | Wang L.,Chang Gung University | And 7 more authors.
The Scientific World Journal

Polymorphonuclear leukocytes (PMNs) are the major leukocytes in the circulation and play an important role in host defense. Intact PMN functions include adhesion, migration, phagocytosis, and reactive oxygen species (ROS) release. It has been known for a long time that adenosine can function as a modulator of adult PMN functions. Neonatal plasma has a higher adenosine level than that of adults; however, little is known about the modulating effects of adenosine on neonatal PMNs. The aim of this study was to investigate the effects of adenosine on neonatal PMN functions. We found that neonatal PMNs had impaired adhesion, chemotaxis, and ROS production abilities, but not phagocytosis compared to adult PMNs. As with adult PMNs, adenosine could suppress the CD11b expressions of neonatal PMNs, but had no significant suppressive effect on phagocytosis. In contrast to adult PMNs, adenosine did not significantly suppress chemotaxis and ROS production of neonatal PMNs. This may be due to impaired phagocyte reactions and a poor neonatal PMN response to adenosine. Adenosine may not be a good strategy for the treatment of neonatal sepsis because of impaired phagocyte reactions and poor response. © 2012 Pei-Chen Hou et al. Source

Liu K.-H.,University of Strasbourg | Liu K.-H.,Chang Gung University | Diana M.,University of Strasbourg | Vix M.,University of Strasbourg | And 3 more authors.
Surgical Endoscopy and Other Interventional Techniques

Background Revisional surgery may be required in a high percentage of patients (up to 30 %) after laparoscopic adjustable gastric banding (LAGB). We report our institutional experience with revisional surgery. Methods FromJanuary 1996 toNovember 2011, 90 patients underwent revisional surgery after failed LAGB. Both Rouxen- Y gastric bypass (RYGB) and sleeve gastrectomy (SG) were proposed. In the presence of gastroesophageal reflux disease, esophageal dysmotility, hiatal hernia, or diabetes, RYGB was preferentially proposed. Results In two cases, revisional surgery was aborted due to local severe adhesions. Eighty-eight patients (74 females; mean age 42.79 ± 10.03 years;mean BMI 44.73 ± 6.19 kg/ m2) successfully underwent revisional SG(n = 48) orRYGB (n = 40). One-stage surgery was performed in 29 cases. Follow-up rate was 78.2 % (n = 61) and 40.9 % (n = 36) at 12 and 24 months respectively. One major complication after SG (staple-line leakage) was observed. Overall postoperative excess weight loss (%EWL) was 31.24, 40.92, 52.41, and 51.68 %at 3, 6, 12, and 24 months of follow-up respectively. Therewas a statistically significant higher%EWLat 1 year in patients≤50 years old (55.9 vs. 41.5 %in patients>50 years old; p = 0.01), of female gender (55.22 vs. 40.73 % in male; p = 0.04), and in patients in which the AGB was in place for ≤5 years (57.09 vs. 47.43 % if>5 years p = 0.02). Conclusions Revisional surgery is safe and effective. Patients≤50 years, of female gender, and with the AGB in place for ≤5 years had better %EWL after revisional surgery. © Springer Science+Business Media New York 2013. Source

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