Shorouk Academy

Cairo, Egypt

Shorouk Academy

Cairo, Egypt
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El Agouza I.M.,Cairo University | Eissa S.S.,Cairo University | El Houseini M.M.,Cairo University | El-Nashar D.E.,National Center for Radiation Research And Technology | Abd El Hameed O.M.,Shorouk Academy
Angiogenesis | Year: 2011

Introduction: The antioxidant Taurine found to display antineoplastic effect through down regulation of angiogenesis and enhancement of tumor cell apoptosis. It has been found that progressive inhibition of apoptosis and induction of angiogenesis may contribute to tumor initiation, growth and metastasis in the pathogenesis of breast cancer. Aim of the study: To correlate taurine level with the levels of some bioomolecules operating in both angiogenesis (VEGF, CD31) and apoptosis (TNF-α and Caspas-3) which could help for breast cancer pronostication and to evaluate a possible role of serum taurine level as an early marker for breast cancer in Egyptian patients. Patients and methods: Four groups of a total 85 female candidates were studied in this work. The first group consists of 50 female patients at National Cancer Institute (NCI), Cairo University were diagnosed and undergoing surgery for breast carcinoma. In the second group 10 having benign breast lesions, were included. The third group consists of five cases, with positive family history. Twenty healthy females were also recruited as control. A preoperative blood sample were taken from each patient to measure serum level of VEGF; Taurine; CA15.3 and TNF- α. Sample of fresh tumor and their corresponding safety margins were obtained from the first and second groups, for determination of caspase-3; histopathological examination and immunohistochemical assay of VEGF and CD31. Result: No significant differences in the serum level of CA15.3 between the breast cancer patients, the high risk and the control group. TNF-α (apoptotic biomolecule) level showed a significant difference only between breast cancer group and control group. The VEGF (angiogenic biomarker) showed a highly significant difference between breast cancer patients, the high risk and the control group. Regarding the antioxidant taurine (antiangiogenic biomolecule) serum level in breast cancer group exhibited a value strongly lower than the high risk and control group. Also the correlative ratio between the angiogenic/apoptotic biomarker (VEGF/TNF-α) showed a highly significant difference between the main previous three groups. Same observation were also noticed in the correlation between angiogenic/antiangiogenic (VEGF/taurine) ratio in the same groups. Moreover the enzymatic activities of Casp-3 in the tissue homogenate were statistically higher in adjacent normal tissues than in malignant tissues. The result of immunohistochemical investigation showed a significant increase in the density of intracellular VEGF and microvessel density expressed as CD31 in cancer cases compared to normal adjacent tissue. Conclusion: It is suggested that assessment of taurine level in sera of patients with high risk for breast cancer are of great value in the early diagnosis of malignant changes in the breast. © 2011 Springer Science+Business Media B.V.


Hefny A.M.,Ain Shams University | Hefny A.M.,United Arab Emirates University | Sorour T.M.,Ain Shams University | Ezzat M.E.,Shorouk Academy
Geotechnical Special Publication | Year: 2016

The task of predicting the performance of deep excavations is challenging due to the existence of many influencing factors. Strength and deformation parameters of soil, type, stiffness of the support system, and sequence of excavation and installation of support elements are very important factors in studying the performance of deep excavations. Performance of deep excavation support systems is related to both stability and deformation. Ground deformation around the excavations can damage surrounding buildings, streets and utilities. Therefore understanding the factors affecting the performance of deep excavations and the ability to predict the behavior of the support system and the associated ground deformations is an important issue for geotechnical engineers. In this paper, two case studies with well documented data of field measurements are analyzed numerically. The analyses are performed using the finite element program "PLAXIS-2D". Two material soil models are implemented in the analyses: the hardening soil model and Mohr Coulomb model. In both analyzed case studies, good agreement between the field measured displacements and the calculated displacement using the hardening soil model is obtained. Results of analysis showed also that the hardening soil model is superior to Mohr Coulomb model in predicting the displacements in both case studies. After calibrating the numerical model, a parametric study is performed to investigate the effect of anchor-pretension-force on the resulting deformation for case study (A) and the effect of strut stiffness on the resulting deformation for case study (B). Results of these analyses showed that both factors have important effects on the resulting excavation-support-system deformation. © ASCE.


Hashiesh F.,ABB | Mostafa H.E.,Suez Canal University | Khatib A.-R.,Shorouk Academy | Helal I.,Ain Shams University | Mansour M.M.,Ain Shams University
IEEE Transactions on Smart Grid | Year: 2012

Increasing expansion of power systems and grids are accompanied nowadays by innovation in smart grid solutions to maintain systems stability. This paper proposes an intelligent wide area synchrophasor based system (IWAS) for predicting and mitigating transient instabilities. The IWAS incorporates artificial neural networks (ANN) for transient stability prediction. The ANN makes use of the advent of phasor measurements units (PMU) for real-time prediction. Coherent groups of generators-which swing together-is identified through an algorithm based on PMU measurements. A remedial action scheme (RAS) is applied to counteract the system instability by splitting the system into islands and initiate under frequency load shedding actions. The potential of the proposed approach is tested using New England 39 bus system. © 2012 IEEE.


Othman M.I.A.,Zagazig University | Othman M.I.A.,Taif University | Atwa S.Y.,Shorouk Academy
Journal of Computational and Theoretical Nanoscience | Year: 2015

The present paper is concerned with the investigation of disturbances in a homogeneous, isotropic elastic medium with generalized thermo-microstretch elastic solid. The formulation is applied to the generalized thermoelasticity based on the Green and Naghdi (GN) theory under the effect of thermomicrostretch elastic solid. The analytical expressions for displacement components, stresses, temperature, components of the couple stress tensor and scalar microstretch are obtained in the physical domain by using the normal mode analysis. These expressions are calculated numerically for the case of aluminum epoxy composite subject to thermal disturbances like material and depicted graphically. Effect of presence of thermo-microstretch elastic solid is analyzed theoretically and numerically. Comparisons are made with the results predicted by both types II and III of (GN) theory. © 2015 American Scientific Publishers All rights reserved.


Othman M.I.A.,Zagazig University | Othman M.I.A.,Shaqra University | Atwa S.Y.,Zagazig University | Atwa S.Y.,Shorouk Academy | Atwa S.Y.,Shaqra University
Meccanica | Year: 2012

In this paper, we constructed the equations of generalized thermoelastic isotropic and homogeneous half-space under hydrostatic initial stress in the context of the Green and Naghdi (GN) theory of types II and III. Normal mode analysis is used to obtain the exact expressions of temperature, displacement and stress. Comparisons are made with the results predicted by GN theory of types II and III in the presence and absence of the hydrostatic initial stress. The temperature, displacement and stress distributions are represented graphically. © Springer Science+Business Media B.V. 2011.


Othman M.I.A.,Zagazig University | Atwa S.Y.,Shorouk Academy | Atwa S.Y.,University of South Africa
International Journal of Thermophysics | Year: 2012

The propagation of plane waves in a fiber-reinforced, anisotropic thermoelastic half-space proposed by Green and Naghdi theory under the effect of magnetic field is discussed. The problem has been solved analytically using normal mode analysis to obtain the exact solution of the temperature, the displacement components, and the thermal stress. Numerical results for the temperature distribution, the displacement components, and the thermal stress are given and illustrated graphically. Comparisons are made with the results predicted by types II and III in the presence and in the absence of the effect of a magnetic field and fiber reinforcement. It is found that the reinforcement and magnetic field have great effects on the distribution of the field quantities. © Springer Science+Business Media, LLC 2012.


Othman M.I.A.,Zagazig University | Othman M.I.A.,Taif University | Atwa S.Y.,Shorouk Academy
Journal of Computational and Theoretical Nanoscience | Year: 2015

A general model of the equation of Green-Naghdi theory with type II and III is applied to study the influence of rotation on the total deformation for an infinite space weakened by a finite linear opening thermal shock. The material is anisotropic thermoelastic half-space. The problem has been solved analytically by using a normal mode method. The variations of the considered variables with the horizontal distance are illustrated graphically. Comparisons are made with the results predicted by the both types II and III of Green-Naghdi theory in the presence and absence of the rotation. Copyright © 2015 American Scientific Publishers.


Othman M.I.A.,Zagazig University | Atwa S.Y.,Zagazig University | Atwa S.Y.,Shorouk Academy | Atwa S.Y.,Shaqra University
Meccanica | Year: 2013

A general model of the equations of the generalized thermoelasticity for an infinite space weakened by a finite linear opening Mode-I crack is solved. The crack is subjected to prescribed temperature and stress distribution in the context of Green-Naghdi theory. The normal mode analysis is used to obtain the exact expressions for the displacement components, the force stresses, the temperature and the couple stresses. Comparisons are made with the results predicted in the both type II, III of Green-Naghdi theory. It is found that a Mode-I crack has great effects on the distribution of field quantities with energy dissipation. © 2012 Springer Science+Business Media Dordrecht.


Othman M.I.A.,Zagazig University | Atwa S.Y.,Shorouk Academy
Mechanics of Advanced Materials and Structures | Year: 2014

A general model of the equations of the generalized thermoelasticity for an infinite space weakened by a finite linear opening Mode-I crack is solved. The material is homogeneous isotropic elastic half space. The total deformation of a Mode-I crack in thermoelastic half-space in the context of Lord-Şhulman and Green-Lindsay theories is studied, as well as the coupled theory and the interaction with each other under the influence of gravity. The normal mode analysis is used to obtain the exact expressions for the physical quantities. Comparisons are made with the results between the three theories in the presence and absence of gravity. © 2014 Copyright © Taylor & Francis Group, LLC.


Othman M.I.A.,Zagazig University | Atwa S.Y.,Shorouk Academy
Meccanica | Year: 2014

A general model of the equation of Green-Naghdi theory (G-N), which is applied to study the influence of reinforcement on the total deformation for an infinite space weakened by a finite linear opening thermal shock, is solved. We study the influence of reinforcement on the total deformation of a rotating thermo-elastic half-space and the mutual interaction under the influence of gravity. The material is homogeneous, isotropic and elastic half-space. The methodology applied here consists of the use of a normal mode analysis to obtain the exact expressions for the temperature, the displacement components, and the stress components. Some particular cases are also discussed in this context. The deformation of a body depends on the nature of the force applied as well as the type of boundary conditions. The variations of the variables considered with the horizontal distance are illustrated graphically. Comparisons are made with the results predicted by the type II and type III cases in the presence and in the absence of the effect of fiber reinforcement. It is found that reinforcement, rotation, and gravity have great effect on the distribution of the field quantities. © 2013 Springer Science+Business Media Dordrecht.

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