Shoolini University of Biotechnology and Management Sciences

shooliniuniversity.com
Solan, India
SEARCH FILTERS
Time filter
Source Type

Kumar D.,Shoolini University of Biotechnology and Management Sciences | Saini N.,Shoolini University of Biotechnology and Management Sciences | Jain N.,Shoolini University of Biotechnology and Management Sciences | Sareen R.,Shoolini University of Biotechnology and Management Sciences
Expert Opinion on Drug Delivery | Year: 2013

Introduction: Gold nanoparticles have been efficiently and effectively used for the delivery of biomolecules and genes along with the potential to offer extremely sensitive diagnostics and imaging methods. Areas covered: This review discusses the historical aspects, synthesis of gold nanoparticles, gold nanoparticles as drug delivery vehicles, photothermal effect of gold nanoparticles and the applications of gold nanoparticles. Gold nanoparticles with their unique optical properties may be useful as biosensors in living cells and has application in the field of drug delivery and photothermal therapy. Depending on the size, shape and degree of aggregation and nature of the protecting organic shells on their surface, gold nanoparticles can appear red, blue and other colors and emit bright resonance light of various wavelengths, which falls under visible region. Because of this property, gold nanoparticles have been extensively used as probes for sensing/imaging a wide range of analysts/targets such as proteins, cells and nucleic acids. Expert opinion: Gold nanoparticles provide an admirable platform for the delivery of biomolecules and genes. © 2013 Informa UK, Ltd.


Sharma A.,Shoolini University of Biotechnology and Management Sciences | Goyal R.,Shoolini University of Biotechnology and Management Sciences
CNS and Neurological Disorders - Drug Targets | Year: 2016

Neurodegeneration is the progressive loss of central neurons which may instigate many disabling psychological and neurological disorders like Alzheimer’s disease, schizophrenia, parkinson’s disease, prion’s disease, and Huntington’s disease. It has become imperative to address the need to discover novel molecular targets and therapeutic strategies to combat neurodegeneration. It is more essential to do so, because most of the accessible treatment focuses on correcting the symptoms of such diseases rather than its underlying pathophysiology. In the present article, we sought to discuss plausible connections between brain ischemic preconditioning and protective measures against chemical neurotoxicity. Brain ischemic preconditioning is reported to be effective against stroke like conditions and is studied chiefly to identify culpable molecular targets. Similarly chemical stressors are reported to be effective in preconditioning neuronal cells against chemical neurotoxicity. Keeping the concept of cross-tolerance in mind this article encompasses the putative targets of both chemical preconditioning and ischemic preconditioning in search for a suitable connection based on the published literature. The distinctive groups of targets are individually discussed and principal targets such as oncogene Akt, glycogen synthase kinase 3-beta and heat shock proteins are emphasised. Identification of these targets may help to develop sophisticated newer therapeutic strategies to cure neurodegenerative disorders. © 2016 Bentham Science Publishers.


Kumar A.,Shoolini University of Biotechnology and Management Sciences | Kumar D.,Shoolini University of Biotechnology and Management Sciences
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014

Lactobacillus is a genus of lactic acid bacteria and described as heterogeneous group of regular, gram-positive, rod shaped, nonmotile, non-spore forming bacteria with absence of catalase enzyme. A total of 30 dairy samples were collected from the local areas of Solan in Himachal Pradesh. In total 30 bacteria were isolated after growth on MRS agar medium and pure culture was obtained by sub-culturing on the same medium. Purity of each culture was confirmed by morphological investigation, Gram's staining and further identification by Lactobacillus specific biochemical tests. Finally 12 bacterial isolates were identified as Lactobacillus spp. after morphological, cultural and biochemical characterization.


Sethi M.,Shoolini University of Biotechnology and Management Sciences | Varun,National Institute of Technology Hamirpur | Thakur N.S.,National Institute of Technology Hamirpur
Solar Energy | Year: 2012

An experimental investigation has been carried out for a range of system and operating parameters in order to analyse the effect of artificial roughness on heat transfer and friction characteristics in solar air heater duct which is having dimple shaped elements arranged in angular fashion (arc) as roughness elements on absorber plate. Duct has an aspect ratio (W/H) of 11, relative roughness pitch (p/e) range of 10-20, relative roughness height (e/D h) range of 0.021-0.036, arc angle (α) range of 45-75° and Reynolds number (Re) ranges from 3600 to 18,000. A considerable increase in heat transfer and friction loss has been observed. The experimental data have been used to develop Nusselt number and friction factor correlations as a function of roughness parameters and operating parameters. © 2012 Elsevier Ltd.


Chauhan R.,Shoolini University of Biotechnology and Management Sciences | Thakur N.S.,National Institute of Technology Hamirpur
Energy | Year: 2014

Jet impingement is an established method of convective heat transfer from the heated surface to the carrier fluid. High heat transfer rates are achieved using impinging jets in solar air heater duct but at the cost of increased friction power penalty. This paper presents thermohydraulic performance of impinging jet solar air heater in the form of effective efficiency and compared the same with that of conventional solar air heater. The study has been carried out to study the effect of Reynolds number, diameter of the jet, streamwise and spanwise pitch on effective efficiency. Based upon the study, it has been concluded that impinging jet solar air heater performs better than the conventional solar air heater for specified range of Reynolds number. The effective efficiency has been computed based upon the correlations developed by the investigators and maximum effective efficiency of 70% has been achieved for impinging jet solar air heater in the range of investigated system and operating parameters. Also, based upon the study, the design plots have been prepared for each jet parameter with temperature rise parameter in order to obtain optimum effective efficiency for desired value of temperature rise. © 2014 Elsevier Ltd.


Pathania D.,Shoolini University of Biotechnology and Management Sciences | Sharma R.,Shoolini University of Biotechnology and Management Sciences
Advanced Materials Letters | Year: 2012

The graft copolymerization of methacrylic acid onto gelatinized potato starch has been carried out at 70° C using chromic acid as initiator. The different reaction parameters such as effect of temperature, initiator and monomer concentrations were optimized to determine the maximum percentage grafting. The maximum grafting efficiency of 87.5% was optimized at reaction temperature (60°C), monomer concentration (0.81molL-1) and initiator concentration (0.02 mmol.L-1). The grafted samples were evaluated for other physico-chemical properties such as swelling behavior, moisture absorption and chemical resistance. The grafted samples were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) techniques. The additional peaks observed in FTIR spectra of grafted samples confirmed the grafting of monomer onto gelatinized starch. The grafted co-polymers have been successfully used for the removal metal ions and organic dyes from aqueous system. © 2012 VBRI Press.


Kumar A.,Shoolini University of Biotechnology and Management Sciences | Kumar D.,Shoolini University of Biotechnology and Management Sciences
Anaerobe | Year: 2015

In the present study twelve Lactobacillus isolates (LBS 1-LBS 12) were characterized for probiotic properties. Out of the twelve, eight isolates (LBS 1-6, 8 and 11) were bile resistant (survival>50% at 0.3% bile salt w/v) and five isolates (LBS 1, 2, 5, 6 and 11) were found acid pH value resistant (survival>50% at pH 3). All twelve isolates inhibited the growth of Staphylococcus aureus whereas isolate LBS 2 also inhibited the growth of Escherichia coli and Salmonella typhimurium. Antibiotic susceptibility testing of isolates was also performed and isolate LBS 2 was selected for further study based on its broad spectrum effect in clinical pathogen inhibition. LBS 2 was characterized phenotypically at Institute of Microbial Technology (IMTECH), Chandigarh, India and was confirmed as Lactobacillus rhamnosus by 16S rDNA sequencing and subsequent analysis using BLAST. The gene sequence was deposited in GenBank with accession number KJ562858. Scanning electron microscopy (SEM) study was used to study invitro epithelial cell adherence and bile salt effect on isolate LBS 2. Epithelial cells adherence assay showed positive results and surface roughness of LBS 2 increased with increase in bile salt (0.15-0.45% w/v). © 2015 Elsevier Ltd.


Sareen R.,Shoolini University of Biotechnology and Management Sciences
Current drug delivery | Year: 2013

In the present investigation chitosan microspheres loaded with flurbiprofen (FLB) were prepared by oil/oil emulsification method for colon specific drug delivery. FLB was entrapped in chitosan microspheres, following coating with Eudragit S-100 utilizing the benefits of pH dependent solubility of Eudragit S-100, so as to prevent the premature release of FLB in upper GIT. Different batches of FLB microspheres were prepared by varying FLB: chitosan ratio (1:1 to 1:4). The effect of chitosan concentration on size, entrapment efficiency, percent drug loading and degree of swelling was evaluated. DSC studies revealed the dispersion of FLB in the matrix of chitosan microspheres. SEM analysis indicated the nearly smooth surface and spherical shape of the prepared microspheres. X-ray diffract gram of FLB microspheres showed less intense peaks as compared to free FLB. In vitro release studies of uncoated FLB- chitosan microspheres showed burst release in initial 4 h, while Eudragit S-100 coated microspheres prevented the premature release of FLB and showed controlled release for 12 h following Higuchi model, thus suitable for colon specific drug delivery.


Pathania D.,Shoolini University of Biotechnology and Management Sciences | Sharma S.,Shoolini University of Biotechnology and Management Sciences
Tenside, Surfactants, Detergents | Year: 2012

Natural cellulosic fiber derived from Ficus carica, was used as eco-friendly biosorbent after alkali treatment for methylene blue dye remediation from aqueous system. The biosorbent was characterized by instrumental techniques such as Fourier transform infrared spectroscopy and scanning electron microscopy. The equilibrium behavior of the biosorbent was investigated in presence of electrolyte and surfactants by batch adsorption experiments. It was observed that in presence of ionic surfactants such as sodium dodecylbenzenesulfonate (SDS) and cetyltrimethyl ammonium bromide (CTABr), the adsorption capacity decreased from 38.97 mg g -1 to 35.64 mg g -1 and 36.75 mg g -1respectively. The equilibrium data were analyzed using the Langmuir and Freundlich isotherm models and were best represented by the Langmuir isotherm model. The pseudo second order kinetic model adequately describes the kinetic data in comparison to first order model. Thermodynamic studies indicated that the adsorption was endothermic and spontaneous. The desorption studies illustrated that the removal of methylene blue dye at optimized condition was 64.95%, out of which 41.53% of methylene blue dye can be recovered by desorption in first cycle. Thus, the biosorbent used in this work proved to be effective materials for the treatment of dye contaminated aqueous systems. © Carl Hanser Publisher Munich.


Kumar R.,Shoolini University of Biotechnology and Management Sciences | Aggarwal R.K.,Dr. Y.S. Parmar University of Horticulture and Forestry | Sharma J.D.,Shoolini University of Biotechnology and Management Sciences
Energy and Buildings | Year: 2013

Artificial neural networks (ANNs) can be used to predict energy consumption more reliably than traditional simulation models and regression techniques. Artificial neural networks are nowadays accepted as an alternative technology offering a way to tackle complex and ill-defined problems. They are not programmed in the traditional way but they are trained using past history data representing the behaviour of a system. They have been used in a number of diverse applications. Results presented in this paper are testimony to the potential of artificial neural networks as a design tool in many areas of building services engineering. © 2013 Elsevier B.V. All rights reserved.

Loading Shoolini University of Biotechnology and Management Sciences collaborators
Loading Shoolini University of Biotechnology and Management Sciences collaborators