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Meerut, India

Chawla P.,Babu Banarasi Das National Institute of Technology and Management | Singh R.,Shobhit University | Saraf S.K.,Northern India Engineering College
Medicinal Chemistry Research | Year: 2012

Two novel series of 4-thiazolidinone derivatives, bearing 2-nitrophenyl imino and 4-nitrophenyl imino groups at position-2 and substituted arylidene groups at position-5, have been synthesized and evaluated for antimicrobial activity against four bacterial and one fungal strain. The success of the synthesis of compounds was confirmed on the basis of spectral analysis. All the newly synthesized compounds were obtained in high yields and exhibited good antibacterial activity; however, the antifungal potential was limited to a few agents. © Springer Science+Business Media, LLC 2011.


Rai S.,Banaras Hindu University | Singh S.,Shobhit University | Shrivastava A.K.,Banaras Hindu University | Rai L.C.,Banaras Hindu University
Photosynthesis Research | Year: 2013

This study examines response of Anabaena sp. PCC 7120 to salt and UV-B stress by combining physiological, biochemical, proteomics and bioinformatics approaches. Sixty five significantly altered protein spots corresponding to 51 protein genes identified using MALDI-TOF MS/MS were divided into nine functional categories. Based on relative abundance, these proteins were grouped into four major sets. Of these, 27 and 5 proteins were up- and downregulated, respectively, both under salt and UV-B while 8 and 11 proteins showed accumulation in salt and UV-B applied singly. Some responses common to salt and UV-B included (i) enhanced expression of FeSOD, alr3090 and accumulation of MDA indicating oxidative stress, (ii) accumulation of PDH, G6P isomerase, FBPaldolase, TK, GAPDH and PGK suggesting enhanced glycolysis, (iii) upregulation of 6-PGD, 6PGL and NADPH levels signifying operation of pentose phosphate pathway, (iv) upregulation of Dps, NDK and alr3199 indicating DNA damage, and (v) accumulation of proteins of ribosome assembly, transcriptional and translational processing. In contrast, enhanced expression of RUBISCO, increased glycolate oxidase activity and ammonium content under salt signify the difference. Salt was found to be more damaging than UV-B probably due to a cumulative effect of ionic, osmotic and oxidative damage. A group of proteins having common expression represent decreased toxicity of salt and UV-B when applied in combination. © 2013 Springer Science+Business Media Dordrecht.


Rai M.K.,Thapar University | Sarkar S.,Shobhit University
Physica Status Solidi (A) Applications and Materials Science | Year: 2011

This paper address the influence of tube diameter on single walled carbon nanotube (CNT) bundle interconnect delay and power output in Very Large Scale application. We find that single-walled carbon nanotube (SWCNT) bundle interconnects are of lower delay than copper interconnect due to low resistance and inductance. Power dissipation decreases with increase in tube diameter of the constituent SWCNT. CNT interconnect resistance and inductance increases with increase in tube diameter. On the other hand, with increase in tube diameter interconnect capacitance decreases. There is a trade off between delay and power dependence on tube diameter. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Gaurav A.,Shobhit University
Mini reviews in medicinal chemistry | Year: 2010

The chemistry of pyrazoloquinolines is well established. This system has proved to be a very attractive scaffold for medicinal chemist in the recent past. Pyrazoloquinolines were extensively studied as bioactive compounds and are known to possess remarkable biological activities such as anti cancer, anti-anxiety, anti-inflammatory, anti-asthmatic, cerebroprotective and antiviral among others. For many of the activities the molecular mode of action is known. Recent research efforts have also highlighted the ability of agents based on pyrazoloquinoline skeleton to modulate adenosine A3 receptors and the phosphodiesterase receptors. In this review the developments in the medicinal chemistry of pyrazoloquinolines is discussed.


Vaddi R.,Padmasri Dr Bv Raju Institute Of Technology | Agarwal R.P.,Shobhit University | Dasgupta S.,Indian Institute of Technology Roorkee
IEEE Transactions on Electron Devices | Year: 2012

In this brief, a new analytical model to compute the potential distribution in gate overlap and underlap regions of a generic double-gate (DG) MOSFET (valid for asymmetric features in front- and back-gate insulator thicknesses, gate bias, and gate work functions) for operation in the subthreshold condition is proposed. A closed form solution to 2-D Poisson's equation is obtained with approximation of parabolic potential function along vertical direction of the device. Conformal mapping technique is applied for modeling fringe electric field in the underlap regions. The proposed potential model is extended in deriving important device parameters such as threshold voltage, threshold voltage rolloff, DIBL, subthreshold swing, etc. Model predictions demonstrate that significant improvement in subthreshold operation can be achieved with 4T asymmetric underlap DG MOSFETs in comparison to 3T symmetric nonunderlap DG MOSFETs. © 2012 IEEE.

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