Shivamogga Institute of Medical science

Shimoga, India

Shivamogga Institute of Medical science

Shimoga, India
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Ramesh Babu K.,Shivamogga Institute of Medical science | Raghavendra H.L.,Davangere University | Kantikar S.M.,Shivamogga Institute of Medical science
International Journal of Pharmaceutical Sciences | Year: 2010

In the present study, acute and sub-chronic toxicity of Terminalia paniculata Roth. (Combretaceae) was studied. In the acute toxicity single oral dose of 2000mg/kg b.w water suspension of Terminalia paniculata was administered to Swiss albino mice of either sex. The results showed no toxicity in terms of general behavior change and mortality and LD50 was found to be more than 2,000 mg/kg. In subacute toxicity study, water extract of Terminalia paniculata was administered orally at a doses of 300, 600 and 1200 mg/kg/day for a period of 30 days. Body weight of dosed and control rats increase throughout the duration of treatment. Water extract didn't cause any changes in haematological and biochemical parameters. On pathological examination, there were no morphological changes under light microscope in the liver and kidneys at the end of the 30 days study. From the study it can be concluded that at a given doses didn't produce any significant toxic effects in during 30 day period of treatment and is safe.

Nagaral J.,Hassan Institute of Medical science | Shashikala G.H.,JJM Medical College | Jagadeesh K.,Shivamogga Institute of Medical science | Sharath Kumar K.,AJ Institute of Medical science | And 3 more authors.
Journal of Clinical and Diagnostic Research | Year: 2013

Background: Calcium Channel Blockers (CCBs) are now widely employed in the treatment of cardiovascular diseases and peri operative hypertension. It has been reported that calcium channel blockers inhibit neuromuscular transmission. They have been shown to increase the neuromuscular blockade produced by neuromuscular blocking agents in in-vitro muscle nerve preparations. The present study is undertaken to demonstrate the effect of calcium channel blocker, verapamil on neuromuscular transmission in albino rats. Objectives: To study the neuromuscular blockade action of verapamil in albino rats. Methods: Twenty four albino rats of either sex weigh 150- 250gms are selected and are randomly divided into 4 equal groups. The experimental rats are divided into four groups of 6 rats each and they are given the following treatment. Group 1(Control) - Normal saline (1ml/ kg), Group 2 (Standard) - Pancuronium (0.04 mg/kg) Group 3-Verapamil (2.5mg/kg), Group 4-given Verapamil (10mg/kg). The time of onset of hind limb paralysis and total duration of recovery are noted using inclined screen method. Results: Analysis of the results of group 3 that was received 2.5mg/kg of Verapamil, there was no onset of paralysis, in group 4 that received injection Verapamil 10mg/kg, showed neuromuscular blockade activity. The mean onset of hind limb paralysis was delayed compared to standard group and the mean duration of hind limb paralysis was shorter than standard group. It was statistically significant (P≤ 0.05). Interpretation and conclusion: It is generally held that external calcium is not necessary for the contraction of mammalian skeletal muscle, the demonstration of inward calcium currents that can be abolished by CCBs in these muscles prompted to re-examine the effect of Verapamil on the neuromuscular transmission. The present study allows us to determine the neuromuscular blockade activity of Verapamil.

Santhosh Kumar M.,JJM Medical College | Jagadeesh K.,Shivamogga Institute of Medical science | Revankar S.P.,Shivamogga Institute of Medical science | Chidananda K.N.,Shivamogga Institute of Medical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Constipation is a common complaint seen in clinical practice and usually refers to persistent, difficult, infrequent, or incomplete defecation. Different groups of drugs available for the treatment of constipations are, stimulant laxatives, bulk forming laxatives, emollient laxatives and osmotic laxatives. β-galactosido-fructose (lactulose) was one of the osmotic laxative used, recently β-galactosido-sorbitol (lactitol) is being promoted as an osmotic laxatives in the management of constipation, which has better palatability when compared to β-galactosido-fructose. It is an open label, randomized, parallel group, comparative study conducted in 90 patients of constipation. They were divided into two groups of 45 each. One group was given β-galactosido-sorbitol and the other β-galactosido-fructose. The study was conducted for duration of seven days. Patient's response to treatment was recorded in follow up visits, which included episodes of spontaneous bowel movement, side effects, palatability and patient's acceptability. The number of bowel evacuations among β-galactosido- sorbitol group was 9.30±1.09 when compared to 7.20±0.68 in β-galactosido-fructose group, being not significant (p>0.05). β-galactosido- sorbitol was significant in terms of less adverse effects when compared to β-galactosido-fructose group(p<0.05).The patients in β-galactosido-sorbitol group had better response, found it more palatable and had better compliance in comparison to β-galactosido-fructose group. β-galactosido-sorbitol is less significant to β-galactosido-fructose in terms of bowel evacuations but more significant in terms of less adverse effects, palatability and compliance.

Devaraju P.B.,Kuvempu University | Padukone S.,Kuvempu University | Veerabhadraiah S.R.,Kuvempu University | Ramachandrappa V.S.,Kuvempu University | And 5 more authors.
Journal of Medical Microbiology | Year: 2013

A 40-year-old man was admitted to hospital with a 5 day history of fever, restlessness and altered sensorium. Peripheral blood smears showed a Plasmodium vivax and Plasmodium falciparum mixed infection as revealed by the presence of rings, schizonts and gametocyte forms of the parasites. The patient soon became unconscious due to subdural haematoma (SDH) associated with disseminated intravascular coagulation and thrombocytopenia. Immediate intervention with a right fronto-parieto temporal craniectomy, evacuation of the SDH and intravenous quinine administration resulted in the patient's complete recovery within 8 days of admission, and he was discharged in good clinical condition. © 2013 SGM.

Sagar M.V.,Shivamogga Institute of Medical science | Mane V.,Shivamogga Institute of Medical science | Praveenkumar N.,Shivamogga Institute of Medical science | Mallappa O.,Shivamogga Institute of Medical science | Ambure O.,Shivamogga Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2015

Introduction: The nutritional well-being of a population is both an outcome and an indicator of national development. Child is the chief victim of interplay of nutrition, socioeconomic and health factors that cause malnutrition. Nutritional status of children under 5 years is one of the most sensitive indicator of development of a particular area. Infant feeding practices comprising of both the breastfeeding as well as complementary feeding have major role in determining the nutritional status of the child. Objective: To assess the prevailing infant and young child feeding practices in the study area. Materials and Methods: Community based cross sectional study was conducted in Bhadravati taluk, Shivamogga. 210 children of either sex in the age group of 12 - 36 months were included in the study. Data was collected from mothers/ guardian using a pretested and semi- structured questionnaire after taking an informed consent. Results: The study findings revealed that breastfeeding was almost universal (99.6%). Initiation of breastfeeding within one hour was practiced in majority i.e. 69.3% of children. Prelacteal feeds were given to 27.6% and colostrum was discarded in only a few (3.3%). Exclusive breastfeeding for the first six months was given to 71.5% of the children. Breast milk was fed on demand in 44.3% of the subjects. © 2015, Indian Journal of Public Health Research & Development. All Rights Reserved.

Krishna M.,Shivamogga Institute of Medical science | Kumar P.N.,Shivamogga Institute of Medical science | Mallappa O.,Shivamogga Institute of Medical science | Ambure O.,Shivamogga Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2016

Introduction: Migrants face serious impediments in accessing the basic health interventions available for the host population. Aims: The objectives were: 1. To study the socio-demographic profile 2. To study the morbidity profile 3. To assess the living conditions 4. To understand the triggering factors for migration Methodology: A cross-sectional study population on 166 migrant unskilled and semi-skilled workers from a private agency in Shivamogga. Data on the research variables was collected with a pre-tested and semi-structured questionnaire. Odds ratio, proportions and chi-square tests were done. Results: Prevalence of overall morbidity among the workers was found to be 80%. Prevalence of hypertension was 78% among workers aged above 45 years. 78% of the male workers migrate for employment, while 94% of the female workers migrate with their husbands. Conclusions: Health problems of migrants are diverse, and calls for coordinated action among various sectors. © 2016, Indian Journal of Public Health Research and Development. All rights reserved.

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