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Dublin, Ireland

Shire Inc | Date: 2015-08-21

The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture.

Compositions of proteins having free thiols, and methods of making and using such compositions, are described.

Shire Inc | Date: 2015-03-23

Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Shire Inc | Date: 2015-05-01

The invention relates, in part, to improved methods of administering -galactosidase A for the treatment of -galactosidase A deficiencies including Fabry disease.

Shire Inc and Ethris GmbH | Date: 2015-10-06

Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis.

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