Shionogi & Co.

Toyonaka, Japan

Shionogi & Co.

Toyonaka, Japan
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Patent
Purdue Pharma and Shionogi & Co. | Date: 2017-05-31

The disclosure relates to Compounds of Formula (I)_(1), R_(4), R_(8), R_(9), and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, pain associated with osteoarthritis, osteoarthritis, UI, an ulcer, IBD, and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof.


A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R^(x) is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R^(1d) is hydrogen, halogen, or the like; R^(2d) is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R^(4d) is a lower alkyl optionally substituted with substituent E, or the like; and R^(6d) is a lower alkyl group optionally substituted with substituent group E].


The present invention provides the following compound having anti-HIV activity of formula:^(1) is C, CR^(1A) or N;A^(2) is C, CR^(2A), or N;A^(3) is CR^(3A), CR^(3A)R^(3B), N, NR^(3c) O, S, SO, or SO_(2) ;A^(4) is CR^(4A), CR^(4A)R^(4B), N, NR^(4C) O, S, SO, or SO2;A^(5) is C, CR^(5A), or N;T^(1) ring is substituted or unsubstituted monocyclic carbocycle or substituted or unsubstituted monocyclic heterocycle;R^(1) is halogen, cyano, nitro or -X^(1)-R^(11);R^(2) is substituted or unsubstituted alkyl and the like;n is 1 or 2;R^(3) is hydrogen, substituted or unsubstituted aromatic varbocyclyl;R^(4) is hydrogen or a carboxy protecting group;the other symbols are as specified in the description.


Patent
Shionogi & Co. | Date: 2017-04-05

The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.


Patent
University of Tokyo, Tohoku University and Shionogi & Co. | Date: 2017-01-04

The present invention provides a compound of formula (I), wherein R^(1), R^(2), R^(3), R^(4a), R^(4b), R^(5a) and R^(5b) are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.


Patent
Shionogi & Co. and ViiV Healthcare | Date: 2017-02-08

The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein


The present invention provides a compound which has an effect of inhibiting amyloid production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or phylactic agent for diseases induced by production, secretion and/or deposition of amyloid proteins. A compound of the formula (I) wherein X is -S- or -O-, R3a is alkyl, haloalkyl or the like, R2a is H, halogen, alkyloxy, haloalkyloxy or the like, R2b is H or the like, R3b is H or alkyl, ring A and ring B is each independently a substituted or unsubstituted aromatic carbocycle, a substituted or unsubstituted aromatic heterocycle or the like, and R1 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof.


Patent
Shionogi & Co. | Date: 2017-06-21

We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV):^(1) is hydrogen or substituted or unsubstituted alkyl,characterized by reacting a compound represented by Formula (V):^(1) has the same meaning as defined above,in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and / or a substituted or unsubstituted phenol.


Patent
University of Tokyo, Tohoku University and Shionogi & Co. | Date: 2017-02-24

A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R^(1), R^(2), R^(3), R^(4a), R^(4c), R^(5 )are as defined in the description.


Patent
Shionogi & Co. | Date: 2017-04-19

The present invention is the following Amphotericin B derivative:

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