Imamura K.,University of Miyazaki |
Asai M.,University of Miyazaki |
Sugamoto K.,University of Miyazaki |
Matsumoto T.,University of Miyazaki |
And 8 more authors.
Bioscience, Biotechnology and Biochemistry
In this study, we focused on the anti-inflammatory effect of cordycepin, 3′-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipo-polysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry. Source