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Miyakonojō, Japan

Imamura K.,University of Miyazaki | Asai M.,University of Miyazaki | Sugamoto K.,University of Miyazaki | Matsumoto T.,University of Miyazaki | And 8 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2015

In this study, we focused on the anti-inflammatory effect of cordycepin, 3′-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipo-polysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry. Source

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