Saito T.,University of Fukui |
Narita N.,University of Fukui |
Yamada T.,University of Fukui |
Ogi K.,University of Fukui |
And 3 more authors.
Otology and Neurotology | Year: 2011
OBJECTIVE: To evaluate the relationship between the length of nerve gap defects, incidence of nerve regeneration, and recovery of gustatory function after severing the chorda tympani nerve (CTN). STUDY DESIGN: Retrospective study. SETTING: University hospital. PATIENTS: Eighty-eight consecutive patients whose CTNs were severed during primary surgery and who underwent secondary surgery were included. Proximal and distal stumps of severed nerves were readapted or approximated during surgery. INTERVENTION: Therapeutic. MAIN OUTCOME MEASURES: Before and after surgery, the taste function was periodically evaluated using electrogustometry. Nerve gaps were classified into 4 groups: readaptation (Group 1), 1 to 3 mm (Group 2), 4 to 6 mm (Group 3), and more than 7 mm (Group 4). RESULTS: Regenerated nerves in the tympanic segment were detected in 36 (41%) of the 88 patients during secondary surgery. The incidence of nerve regeneration was 100% (10/10) in Group 1, 45% (10/22) in Group 2, 47% (9/19) in Group 3, and 19% (7/37) in Group 4. There was a significant difference between the length of nerve gap defects and incidence of nerve regeneration (p < 0.001). In the 36 patients with a regenerated CTN, the incidence of gustatory function recovery was 60% (6/10) in Group 1, 50% (5/10) in Group 2, 56% (5/9) in Group 3, and 43% (3/7) in Group 4. There was no significant difference between the length of nerve gap defects and incidence of taste function recovery. CONCLUSION: Reconstruction of a severed CTN is very important for regeneration. However, the regenerated CTN in the tympanic segment does not always reinnervate the fungiform papillae. © 2011, Otology &Neurotology, Inc.
Saito T.,University of Fukui |
Ito T.,University of Fukui |
Narita N.,University of Fukui |
Yamada T.,University of Fukui |
Manabe Y.,Shinseikai Toyama Hospital
Annals of Otology, Rhinology and Laryngology | Year: 2011
Objectives: The aim of this study was to evaluate the mean number of regenerated fungiform taste buds per papilla and perform light and electron microscopic observation of taste buds in patients with recovered taste function after severing the chorda tympani nerve during middle ear surgery. Methods: We performed a biopsy on the fungiform papillae (FP) in the midlateral region of the dorsal surface of the tongue from 5 control volunteers (33 total FP) and from 7 and 5 patients with and without taste recovery (34 and 29 FP, respectively) 3 years 6 months to 18 years after surgery. The specimens were observed by light and transmission electron microscopy. The taste function was evaluated by electrogustometry. Results: The mean number of taste buds in the FP of patients with completely recovered taste function was significantly smaller (1.9 ± 1.4 per papilla; p < 0.01) than that of the control subjects (3.8 ± 2.2 per papilla). By transmission electron microscopy, 4 distinct types of cell (type I, II, III, and basal cells) were identified in the regenerated taste buds. Nerve fibers and nerve terminals were also found in the taste buds. Conclusions: It was clarified that taste buds containing taste cells and nerve endings do regenerate in the FP of patients with recovered taste function.
Ogi K.,Shinseikai Toyama Hospital |
Takabayashi T.,University of Fukui |
Sakashita M.,University of Fukui |
Susuki D.,University of Fukui |
And 3 more authors.
Auris Nasus Larynx | Year: 2014
Objective: Asian sand dust (ASD), originating in the deserts of Mongolia and China, spreads over large areas and is associated with adverse effects on human health in East Asia, including asthma, heart disease, and some allergic diseases. However, the effect of ASD on patients with seasonal allergic rhinitis caused by Japanese cedar pollen (SAR-JCP), the most common form of allergic rhinitis, remains unclear. The aim of this study was to investigate the effect of ASD on SAR-JCP patients. Methods: A total of 41 patients with SAR-JCP recorded nasal and ocular allergic symptom scores in a diary. We assessed the influence of ASD events on patients with SAR-JCP during the JCP season and before and after the JCP season. Results: ASD events did not influence nasal and ocular allergy symptoms during the JCP season. Scores for sneezing and runny nose were significantly increased by ASD events in the pre-JCP season. Ocular symptom scores were significantly increased by ASD events in the post-JCP season. Conclusion: Our results suggest that ASD may exacerbate allergy symptoms even before mass scattering of JCP, which usually does not cause allergic symptoms in patients with SAR-JCP. ASD also induced conjunctivitis symptoms after the JCP season. However, we did not observe any adverse effects of ASD on allergic symptoms during the JCP season. © 2014 Elsevier Ireland Ltd.
PubMed | University of Fukui and Shinseikai Toyama Hospital
Type: Journal Article | Journal: Auris, nasus, larynx | Year: 2014
Asian sand dust (ASD), originating in the deserts of Mongolia and China, spreads over large areas and is associated with adverse effects on human health in East Asia, including asthma, heart disease, and some allergic diseases. However, the effect of ASD on patients with seasonal allergic rhinitis caused by Japanese cedar pollen (SAR-JCP), the most common form of allergic rhinitis, remains unclear. The aim of this study was to investigate the effect of ASD on SAR-JCP patients.A total of 41 patients with SAR-JCP recorded nasal and ocular allergic symptom scores in a diary. We assessed the influence of ASD events on patients with SAR-JCP during the JCP season and before and after the JCP season.ASD events did not influence nasal and ocular allergy symptoms during the JCP season. Scores for sneezing and runny nose were significantly increased by ASD events in the pre-JCP season. Ocular symptom scores were significantly increased by ASD events in the post-JCP season.Our results suggest that ASD may exacerbate allergy symptoms even before mass scattering of JCP, which usually does not cause allergic symptoms in patients with SAR-JCP. ASD also induced conjunctivitis symptoms after the JCP season. However, we did not observe any adverse effects of ASD on allergic symptoms during the JCP season.
Ayaki M.,Keio University |
Toda I.,Mimamiaoyama Eye Clinic |
Tachi N.,Shinseikai Toyama Hospital |
Negishi K.,Keio University |
Tsubota K.,Keio University
Neuropsychiatric Disease and Treatment | Year: 2016
Purpose: Dry eye disease (DED) is potentially associated with sleep and mood disorders. This study evaluated sleep quality in patients with DED using a questionnaire-based survey before and after topical eyedrop treatment. The effectiveness of sleep and ophthalmic services in assisting with sleep problems in patients with eye disease was also assessed. Methods: Seventy-one consecutive patients with DED visiting eight general eye clinics in various locations answered a questionnaire containing the Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale. Photophobia and chronotype (morningness/eveningness) were also evaluated with two representative questions from established questionnaires (National Eye Institute Visual Function Questionnaire-25 and Morningness/Eveningness questionnaire). Follow-up evaluation was conducted by interview or mail 3–10 months after the initial evaluation. A sleep service was established in two eye clinics to identify possible ocular diseases related to sleep and mood disorders; it comprised a questionnaire, sleep diary, actigram, medical interviews, visual field testing, retinal ganglion cell layer thickness measurement, and DED examination. Results: Patients with newly diagnosed DED exhibited a greater improvement in sleep after DED treatment compared with patients with established DED. Improvement in Pittsburgh Sleep Quality Index was significant (P<0.05) and strongly correlated with improvement in Hospital Anxiety and Depression Scale (P<0.05) for new patients, but not for patients with established DED. Ten eye clinic patients visited the sleep service and nine of them had DED. They were successfully treated with eyedrops and sleep services, which included blue-light-shield eyewear and wearable blue-light therapy lamps according to their problem. Conclusion: Sleep quality improved in patients with DED after topical treatment with or without the sleep service. Psychiatric treatment focusing on sleep disorders could be beneficial for patients with DED. © 2016 Ayaki et al.
Yokogawa H.,Kanazawa University |
Kobayashi A.,Kanazawa University |
Yamazaki N.,Kanazawa University |
Ueta Y.,Shinseikai Toyama Hospital |
And 3 more authors.
Clinical Ophthalmology | Year: 2013
Background: The purpose of this paper is to report our experience of Descemet's stripping and non-Descemet's stripping automated endothelial keratoplasty (DSAEK/nDSAEK) for microcorneas using 6.0 mm donor grafts. Methods: Three eyes of two patients (a 56-year-old woman and a 59-year-old woman) with microcornea and suffering from bullous keratopathy were treated with either DSAEK or nDSAEK. A small donor graft (6.0 mm) was inserted into the anterior chamber using a double glide (Busin glide and intraocular lens sheet glide) donor insertion technique. Both patients were followed for at least 12 months. Clinical outcomes, including intraoperative and postoperative complications, visual acuity, and endothelial cell density were evaluated. Results: In all three cases (100%), no intraoperative complications were noted. In one case with a flat keratometry value (32.13 D), a partial donor detachment was noted one day postoperatively, but it was reattached by rebubbling. In another case, rejection was noted 8 months postoperatively, but treatment with systemic corticosteroids was successful. A clear cornea remained in all three cases (100%), with best-corrected visual acuity greater than 20/100 (mean 20/50) at 12 months. Mean postoperative endothelial cell counts were 2,603 ± 18 cells/mm2 at 6 months (7.4% decrease from preoperative donor cell counts) and 1,799 ± 556 cells/mm2 at 12 months (36.5% decrease). Conclusion: We report for the first time the successful use of a small donor graft (6.0 mm) for DSAEK/nDSAEK in cases of microcornea. Additional studies using a large number of patients are required to evaluate fully the potential advantages and drawbacks of small diameter donor grafts for microcornea. © 2013 Yokogawa et al.
Ohta S.,Shinseikai Toyama Hospital |
Komai O.,Shinseikai Toyama Hospital |
Hanakawa H.,Shinseikai Toyama Hospital
Modern Rheumatology | Year: 2014
Background This is a randomized comparative study of the efficacy of celecoxib and loxoprofen in patients with frozen shoulder (scapulohumeral periarthritis). Methods Patients with frozen shoulder who presented with pain as the symptom were divided at random into a celecoxib treatment group (100 mg/dose, twice daily; n = 37) and a loxoprofen treatment group (60 mg/dose, 3 times daily; n = 33). Medication was continued for 1-2 weeks in each group. Results Each patient was asked to rate the pain on a visual analog scale (score 0-5). This score significantly improved (indicating marked alleviation of pain) in both the celecoxib group (from 3.41 ± 0.86 before treatment to 2.30 ± 1.02 after treatment) and the loxoprofen group (from 3.73 ± 0.67 before treatment to 2.76 ± 0.96 after treatment). In the analysis of disappearance of pain, the percentage of patients showing disappearance of nocturnal pain was significantly higher in the celecoxib group (71.4 %) than in the loxoprofen group (36.8 %). Conclusions The results confirm that celecoxib is comparable to loxoprofen in terms of analgesic efficacy in patients with frozen shoulder. Among other findings, we report that celecoxib was more effective for nocturnal pain than loxoprofen. © 2013 Japan College of Rheumatology.
Nakanishi M.,Shinseikai Toyama Hospital |
Yoshida Y.,Shinseikai Toyama Hospital |
Natazuka T.,Shinseikai Toyama Hospital
Lung Cancer | Year: 2012
Our previous retrospective study indicated a good response rate of non-small-cell lung carcinoma (NSCLC) to transarterial infusion chemotherapy, but the precise effect remains unresolved. This prospective study enrolled 25 patients with stage III or IV or recurrent NSCLC without distant metastasis (M1b) who were not candidates for either standard chemotherapy or chemoradiotherapy. The feeding arteries of each tumor detected by angiography were recorded and tumor staining was visually graded on a scale of I-IV. Docetaxel and cisplatin (25 and 25mg/m 2, respectively) were administered by arterial infusion. The total dose of each was divided among feeding arteries according to the degree of tumor staining. The end points included response rate, progression-free survival (PFS), overall survival (OS) and toxicity. Correlations between effects and some clinical aspects were investigated. Of 25 patients enrolled between May 2007 and April 2011, 24 of them were evaluable. One complete response and 12 partial responses were achieved for an overall response rate of 52% (95% confidence interval [CI]: 35-69%). The median progression-free survival and overall survival periods were 6.5 (95% CI: 5.4-7.6) and 17.4 (95% CI: 14.2-20.6) months, respectively. The 1- and 2-year survival rates were 81% and 32%, respectively. Grade 3-4 hematological toxicity was not evident. Grade 3 general fatigue or appetite loss developed in patients with performance status (PS) ≥3. Neither grade 4 non-hematological toxicity nor treatment-related death occurred. Among various clinical aspects, ECOG PS significantly correlated with PFS and OS, whereas tumor staining significantly correlated with response. Survival was significantly better for patients with good PS (0 or 1) than poor PS (≥2) and those with, than without grade IV tumor staining. If a sufficient number of feeding arteries are detected and the tumor is appropriately stained, then arterial infusion chemotherapy has favorable response rates with less toxicity for patients with stage III or IV or recurrent NSCLC without distant metastasis (M1b) who cannot tolerate standard chemotherapy. © 2012 Elsevier Ireland Ltd.
Nakanishi M.,Shinseikai Toyama Hospital
Primary Care Respiratory Journal | Year: 2011
AIMS: The numbers of patients with influenza-like illnesses increase during influenza outbreaks. A study was undertaken to distinguish community-acquired pneumonia (CAP) from influenza based on clinical signs and symptoms. METHODS: This retrospective study investigated patients with positive results in the rapid influenza antigen test and those diagnosed with CAP during an influenza A/H1N1 pandemic. Significant factors for predicting risk for CAP within 48 hrs from onset and at diagnosis were selected by multiple regression analysis. RESULTS: Within 48 hrs of onset and at diagnosis, age and coarse crackles significantly increased the risk of CAP whereas sick contact, sore throat, and rhinorrhoea significantly decreased the risk of CAP. Duration of illness, sputum, dyspnoea, chest pain, and coarse crackles also significantly increased the risk of CAP at diagnosis. CONCLUSIONS: CAP differed somewhat from influenza even within 48 hrs of onset and the differences became even more evident thereafter. © 2010 Primary Care Respiratory Society UK.
Tate H.,Shinseikai Toyama Hospital |
Sasakawa Y.,Shinseikai Toyama Hospital |
Tachi N.,Shinseikai Toyama Hospital
Japanese Journal of Clinical Ophthalmology | Year: 2016
Purpose: To report changes in visual functions and ganglion cell complex (GCC) in the retina after surgery for idiopathic epiretinal membrane. Cases and Method: This study was made on 23 eyes of 21 cases who received surgery for idiopathic epiretinal membrane. The series comprised 11 male and 12 female eyes. The age averaged 70 years. All the cases were evaluated by optical coherence tomography (OCT) and by Humphrey perimetry. Results: Thickness of GCC decreased in the inner four circles after surgery. The decrease was more pronounced in the temporal sector. Visual acuity improved after surgery regardless of change in GCC or in mean deviation of perimetric findings. There were 15 eyes that showed decrease in pattern standard deviation (PSD) after surgery. Eight out of the 15 eyes showed agreement in the area of GCC thinning and decrease in PSD. Conclusion: Vitreous surgery for idiopathic epiretinal membrane may be followed by GCC thinning in the parafoveal area. The thinning may be more pronounced in the temporal sector. GCC thinning may be associated with decrease in retinal sensitivity.