Shimadzu Research Laboratory Shanghai Co.

Shanghai, China

Shimadzu Research Laboratory Shanghai Co.

Shanghai, China
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Patent
Shimadzu Corporation and SHIMADZU RESEARCH LABORATORY SHANGHAI Co. | Date: 2012-01-24

This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.


Li X.,Fudan University | Wang H.,Shimadzu Research Laboratory Shanghai Company | Sun W.,Shimadzu Research Laboratory Shanghai Company | Ding L.,Shimadzu Research Laboratory Shanghai Company
Analytical Chemistry | Year: 2010

Current direct analysis methods in mass spectrometry (MS) are predominantly focused on desorbing and ionizing samples in the solid phase. Some sampling difficulties are associated with liquid (solution) or gas samples. The present study has expanded direct MS analysis to solution samples by using the desorption corona beam ionization (DCBI) technique in combination with poly(dimethylsiloxane) (PDMS) substrate sampling. Typically, the PDMS substrate is dipped in water for microextraction of pesticide compounds and then is transferred to an MS ion source for desorption and ionization. This approach improves the detection limit for DCBI and allows more organic compounds in complex mixtures to be identified within seconds. The practical application of this device is demonstrated by identifying five pesticides (acephate, isoprocarb, dimethoate, dichlorvos, and dicofol) in water. The obtained detection limits of pesticides are 1 μg/L, the measured dynamic ranges are 3 orders of magnitude, the calculated correlation coefficients are between 0.939 and 0.979 at concentration levels of 5-5000 μg/L, and the repeatabilities defined as a relative standard deviation of five successive injections are in the range of 13-17%. The results indicate that the DCBI technique coupled with PDMS sampling is an excellent method for the analysis of organic pesticides in solution, and it also opens up a new avenue for direct MS studies of solution samples with general importance. © 2010 American Chemical Society.


Wang H.,Shimadzu Research Laboratory Shanghai Co. | Sun W.,Shimadzu Research Laboratory Shanghai Co. | Zhang J.,Shimadzu Research Laboratory Shanghai Co. | Yang X.,Shimadzu Research Laboratory Shanghai Co. | And 2 more authors.
Analyst | Year: 2010

A novel Desorption Corona Beam Ionization (DCBI) source for direct analysis of samples from surface in mass spectrometry is reported. The DCBI source can work under ambient conditions without time-consuming sample pretreatments. The source shares some common features with another ionization source - Direct Analysis in Real Time (DART), developed earlier. For example, helium was used as the discharge gas (although only corona discharge is involved in the present source), and heating of the discharge gas is required for sample desorption. However, the difference between the two sources is substantial. In the present source, a visible thin corona beam extending out around 1 cm can be formed by using a hollow needle/ring electrode structure. This feature would greatly facilitate localizing sampling areas and performing imaging/profiling experiments. The DCBI source is also capable of performing progressive temperature scans between room temperature and 450 °C in order to sequentially desorb samples from the surface and, therefore, to achieve a rough separation of the individual components in a complex mixture, resulting in less congestion in the mass spectrum acquired. Mass spectra for a broad range of compounds (pesticides, veterinary additives, OTC drugs, explosive materials) have been acquired using the DCBI source. For most of the compounds tested, the heater temperature required for efficient desorption is at least 150 °C. The molecular weight of the sample that can be desorbed/ionized is normally below 600 dalton even at the highest heater temperature, which is mainly limited by the volatility of the sample. © 2010 The Royal Society of Chemistry.


Patent
Shimadzu Research Laboratory Shanghai Co. | Date: 2013-02-26

A linear ion beam bonding apparatus and an array structure thereof, comprising a pair of primary radiofrequency electrodes (501 and 502) extending along the axial direction and oppositely arranged on two sides of the central axis of the linear ion beam bonding apparatus. Section patterns on different section planes of each of the primary radiofrequency electrodes (501 and 502) and perpendicular to the central axis are all kept symmetric via a primary symmetric plane (506) of the central axis. Radiofrequency voltages attached to the primary radiofrequency electrodes (501 and 502) are of identical phases. An ion extraction groove (84) is arranged on at least one of the primary radiofrequency electrodes (501 and 502), while at least one pair of auxiliary electrodes (503 and 505) are arranged on two sides of the pair of primary radiofrequency electrodes (501 and 502). The auxiliary electrodes (503 and 505) are arranged in duality to the primary symmetric plane (506). At least one of the auxiliary electrodes (503 and 505) is provided with a finite number of symmetric planes (507), while a minimal angle greater than 0 degrees and less than 90 degrees is provided between each symmetric plane (507) and the symmetric plane (506) of the primary radiofrequency electrodes (501 and 502). By means of this, a quadrupole field component of an ion beam bonding radiofrequency electric field within the ion beam bonding apparatus is strengthened.


Patent
SHIMADZU RESEARCH LABORATORY SHANGHAI Co. | Date: 2013-12-02

The present invention provides a method for preparing an ion optical device. A substrate is fabricated with a hard material adapted for a grinding process, the substrate at least including a planar surface, and including at least one insulating material layer. Next, one or more linear grooves are cut on the planar surface, to form multiple discrete ion optical electrode regions on the planar surface separated by the linear grooves. Then, conductive leads are fabricated on other substrate surfaces than the planar surface and in a through hole inside the substrate, to provide voltages required on ion optical electrodes. By using high-hardness materials in cooperation with high-precision machining, higher precision and a desired discrete electrode contour can be obtained.


Patent
SHIMADZU RESEARCH LABORATORY SHANGHAI Co. | Date: 2010-04-12

The present invention involves a method and a device for sequentially desorbing and ionizing mixed analytes on a solid surface with a gradual temperature scan, and continuously collecting data for multiple times in the gradual desorption and ionization process. By gradually increase the temperature of at least one part of the sample, the analytes with different thermal desorption capabilities are sequentially desorbed from surfaces of the solid sample, thereby providing a sample pre-separation scheme, so as to reduce difficulties to subsequent mass spectrum detection. Meanwhile, since mass spectrum data of the analytes with different boiling points is collected for multiple times during a temperature scan, the analytes with a low boiling point can be detected first at lower temperature in order to avoid rapid exhaustion at higher temperature, thereby improving the detection efficiency of the analytes with low boiling points.


Patent
Shimadzu Research Laboratory Shanghai Co. | Date: 2011-04-22

The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.


Patent
Shimadzu Research Laboratory Shanghai Co. | Date: 2014-03-26

An ion guiding device (3) and method, the ion guiding device (3) having: a group of electrode arrays distributed along an axis in space, and a power supply providing an asymmetric alternating current (AC) electric field substantially along the axis; the AC field asymmetrically alternates between positive and negative along the axis to drive the ions move in the direction corresponding to said AC electric field such that ions are guided into said ion guiding device (3) in a continuous or quasi-continuous flow manner while being guided out in a pulsed manner along the axis.


Patent
Shimadzu Research Laboratory Shanghai Co. | Date: 2012-12-12

A tandem mass spectrometer of quadrupole mass filter and ion trap used in combination, and a multi-mode analytical approach from single-level to multi-stage mass spectrum (MS) analysis realized in the above mass spectrometer are provided in the present invention. The mass spectrometer includes an ion source (3), a quadrupole mass filter (6) located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector (12) placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.


Patent
SHIMADZU RESEARCH LABORATORY SHANGHAI Co. | Date: 2011-01-26

A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

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