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Sudakov M.,Shimadzu Research Laboratory Europe Ltd. | Sudakov M.,Center for Ion Optical Technologies | Kumashiro S.,Shimadzu Corporation
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2011

A new approach for design of time-of-flight system is proposed. Unlike in conventional systems, where motion is isochronous in only one (flight) direction, new system has property of isochronous motion in orthogonal (drift) direction as well. Approach is applied for design of multi-reflecting time-of-flight system based on planar mirrors with zig-zag like trajectory. New system allows increasing flight path of the beam by order of magnitude compared to conventional systems, while keeping size of the ion mirror reasonably small. A new multi-reflecting time-of-flight system of size 500×500×20 mm3, with a flight path 20 m is designed. Simulations of ion motion in a new system show feasibility of resolving power over 50,000. © 2010 Elsevier B.V. Allrights reserved.

Cubric D.,Shimadzu Research Laboratory Europe Ltd. | Kholine N.,Russian Academy of Sciences | Konishi I.,Shimadzu Corporation
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2011

A new class of charged particle energy analyzers, spheroid energy analyzers (SEA) that are characterized with very high energy resolution and transmission, is presented. A prototype analyzer was built that has achieved a relative energy resolution of 0.05% at a transmission of 21% out of a 2π steradian. A very high order of focusing of these analyzers is presented via simulation that indicates the existence of 13th order focusing in one of our models. This promises further improvements in energy resolution in future practical analyzer embodiments. A novel geometrical framework is presented, which describes SEA analyzers in general terms within which well known types of analyzers CMA and CHA appear to be only particular examples. © 2011 Elsevier B.V. Allrights reserved.

Jiang D.,Fudan University | Jiang G.-Y.,Fudan University | Li X.-X.,Fudan University | Xu F.-X.,Fudan University | And 3 more authors.
Analytical Chemistry | Year: 2013

An ion trap (IT) mass analyzer can be simply built with low cost material - the printed circuit board (PCB). A printed circuit board ion trap (PCBIT) can perform ion trapping, mass analysis, and tandem mass spectrometry as a conventional ion trap mass analyzer. In a PCBIT, each PCB electrode was fabricated to specially designed patterns with several separate electric strips. The strips' electrodes were insulated from each other and applied with different voltages during the experiment. Therefore, the electric field distribution inside the ion trap region may be adjusted and optimized by simply adjusting the voltage on each strip. The performance of the PCBIT can also be optimized since the property of an ion trap is strongly dependent on the field distribution. The fabrication, operation, and performance of the PCBIT are described and characterized in this paper. A prototype PCBIT was built with two pairs of 64 mm × 12 mm PCB rectangular plates and one pair of 10 mm × 10 mm stainless steel square plates. A mass analysis with a resolving power of over 1500 and a mass range of around 3000 Th was observed. The mass-selected isolation and collision-induced dissociation (CID) of ions were also tested using the homemade PCBIT system. The adjustable electric field distribution, simple structure, and low cost of PCBIT make it certainly suitable for the further miniaturization of the portable mass spectrometer. © 2013 American Chemical Society.

Mark L.P.,University of Warwick | Gill M.C.,Shimadzu Research Laboratory Europe Ltd. | Mahut M.,University of Vienna | Derrick P.J.,University of Warwick | Derrick P.J.,Massey University
European Journal of Mass Spectrometry | Year: 2012

A novel nano-electrospray emitter has been developed containing two separated channels running throughout the length of the emitter. The emitters have been fabricated from theta-shaped borosilicate capillaries. Loading of different solutions into the two different channels opens up the possibility to study short timescale interactions within a Taylor cone common to both channels. The common Taylor cone constitutes an extremely small mixing volume of the order of femtolitres. The products of electrospray from the dual-channel emitters have been analysed by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. Results are presented for interactions of vancomycin with diacetyl-l-lysyl-d-alanyl-d-alanine and interactions of vancomycin with deuterated vancomycin. On the basis of these results, it is concluded that, during electrospray, specific non-covalent adducts have been formed and that there have been exchange reactions involving making and breaking of covalent bonds. © 2012 IM Publications LLP. All rights reserved.


The present invention is concerned with an ion analysis apparatus for conducting differential ion mobility analysis and mass analysis. In embodiments, the apparatus comprises a differential ion mobility device in a vacuum enclosure of a mass spectrometer, located prior to the mass analyser, wherein the pumping system of the apparatus is configure to provide an operating pressure of 0.005 kPa to 40 kPa for the differential ion mobility device, and wherein the apparatus includes a digital asymmetric waveform generator that provides a waveform of frequency of 50 kHz to 25 MHz. Examples demonstrate excellent resolving power and ion transmission. The ion mobility device can be a multipole, for example a 12-pole and radial ion focusing can be achieved by applying a quadrupole field to the device in addition to a dipole field.

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