Shimadzu Research Laboratory Europe Ltd.

Manchester, United Kingdom

Shimadzu Research Laboratory Europe Ltd.

Manchester, United Kingdom

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Patent
Shimadzu Research Laboratory Europe Ltd. | Date: 2016-10-21

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.


Mark L.P.,University of Warwick | Gill M.C.,Shimadzu Research Laboratory Europe Ltd | Mahut M.,University of Vienna | Derrick P.J.,University of Warwick | Derrick P.J.,Massey University
European Journal of Mass Spectrometry | Year: 2012

A novel nano-electrospray emitter has been developed containing two separated channels running throughout the length of the emitter. The emitters have been fabricated from theta-shaped borosilicate capillaries. Loading of different solutions into the two different channels opens up the possibility to study short timescale interactions within a Taylor cone common to both channels. The common Taylor cone constitutes an extremely small mixing volume of the order of femtolitres. The products of electrospray from the dual-channel emitters have been analysed by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. Results are presented for interactions of vancomycin with diacetyl-l-lysyl-d-alanyl-d-alanine and interactions of vancomycin with deuterated vancomycin. On the basis of these results, it is concluded that, during electrospray, specific non-covalent adducts have been formed and that there have been exchange reactions involving making and breaking of covalent bonds. © 2012 IM Publications LLP. All rights reserved.


Cubric D.,Shimadzu Research Laboratory Europe Ltd. | De Fanis A.,Shimadzu Research Laboratory Europe Ltd. | Konishi I.,Shimadzu Corporation | Kumashiro S.,Shimadzu Corporation
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2011

Main design points and measurement results from an electron energy analyzer capable of simultaneous spectral acquisition over a wide energy range are presented. This analyzer has been first applied in the field of Auger electron spectroscopy, where we demonstrate the capability of fast data acquisition at high vacuum, that in turn can enable applications in semiconductor inspection and in the usual SEM environments. Steps for further improvement of the transmission and acquisition speed are highlighted. © 2010 Elsevier B.V. Allrights reserved.


Sudakov M.,Shimadzu Research Laboratory Europe Ltd. | Sudakov M.,Center for Ion Optical Technologies | Kumashiro S.,Shimadzu Corporation
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2011

A new approach for design of time-of-flight system is proposed. Unlike in conventional systems, where motion is isochronous in only one (flight) direction, new system has property of isochronous motion in orthogonal (drift) direction as well. Approach is applied for design of multi-reflecting time-of-flight system based on planar mirrors with zig-zag like trajectory. New system allows increasing flight path of the beam by order of magnitude compared to conventional systems, while keeping size of the ion mirror reasonably small. A new multi-reflecting time-of-flight system of size 500×500×20 mm3, with a flight path 20 m is designed. Simulations of ion motion in a new system show feasibility of resolving power over 50,000. © 2010 Elsevier B.V. Allrights reserved.


Ding L.,Shimadzu Research Laboratory Europe Ltd. | Badheka R.,Shimadzu Research Laboratory Europe Ltd. | Ding Z.,University of Manchester | Nakanishi H.,Shimadzu Research Laboratory Europe Ltd.
Journal of the American Society for Mass Spectrometry | Year: 2013

The Planar electrostatic ion trap expands the trapping space of the linear electrostatic ion trap, giving rise to higher tolerance to space charge. A rotational symmetrical design was made, which has a trapping field between two layers of concentric circular electrodes, and the ions are trapped to oscillate around the center plane between the electrodes. The oscillatory motions of the ions were simulated and the field distribution was optimized to achieve isochronous motion against energy spread in R, z, and φ directions. The image charge signal can be picked up by more than one circular electrode and using FFT the mass resolution for the optimized trap can reach 80,000 FWHM. While Fourier transform of the image charge signal generates many high harmonic peaks, the unwanted harmonic peaks can be eliminated by linear combination of image charge signals from multiple pick-up electrodes to give satisfactory results. © 2013 American Society for Mass Spectrometry.


Jiang D.,Fudan University | Jiang G.-Y.,Fudan University | Li X.-X.,Fudan University | Xu F.-X.,Fudan University | And 3 more authors.
Analytical Chemistry | Year: 2013

An ion trap (IT) mass analyzer can be simply built with low cost material - the printed circuit board (PCB). A printed circuit board ion trap (PCBIT) can perform ion trapping, mass analysis, and tandem mass spectrometry as a conventional ion trap mass analyzer. In a PCBIT, each PCB electrode was fabricated to specially designed patterns with several separate electric strips. The strips' electrodes were insulated from each other and applied with different voltages during the experiment. Therefore, the electric field distribution inside the ion trap region may be adjusted and optimized by simply adjusting the voltage on each strip. The performance of the PCBIT can also be optimized since the property of an ion trap is strongly dependent on the field distribution. The fabrication, operation, and performance of the PCBIT are described and characterized in this paper. A prototype PCBIT was built with two pairs of 64 mm × 12 mm PCB rectangular plates and one pair of 10 mm × 10 mm stainless steel square plates. A mass analysis with a resolving power of over 1500 and a mass range of around 3000 Th was observed. The mass-selected isolation and collision-induced dissociation (CID) of ions were also tested using the homemade PCBIT system. The adjustable electric field distribution, simple structure, and low cost of PCBIT make it certainly suitable for the further miniaturization of the portable mass spectrometer. © 2013 American Chemical Society.


Patent
SHIMADZU RESEARCH LABORATORY EUROPE Ltd | Date: 2010-04-30

The present invention is concerned with an ion analysis apparatus for conducting differential ion mobility analysis and mass analysis. In embodiments, the apparatus comprises a differential ion mobility device in a vacuum enclosure of a mass spectrometer, located prior to the mass analyser, wherein the pumping system of the apparatus is configure to provide an operating pressure of 0.005 kPa to 40 kPa for the differential ion mobility device, and wherein the apparatus includes a digital asymmetric waveform generator that provides a waveform of frequency of 50 kHz to 25 MHz. Examples demonstrate excellent resolving power and ion transmission. The ion mobility device can be a multipole, for example a 12-pole and radial ion focusing can be achieved by applying a quadrupole field to the device in addition to a dipole field.


Patent
Shimadzu Research Laboratory Europe Ltd. | Date: 2013-11-06

Control circuitry for stabilising a DC voltage outputted by a DC power supply against changes in ambient temperature. The control circuitry includes: measurement circuitry configured to output a measurement voltage representative of a DC voltage outputted by a DC power supply; reference circuitry configured to output a reference voltage; and comparison circuitry configured to compare the measurement voltage with the reference voltage and, based on the comparison, output a control signal for controlling the DC voltage outputted by the DC power supply. At least one temperature-sensitive component of the control circuitry is located in an enclosure configured to maintain a substantially constant temperature within the enclosure.


Patent
Shimadzu Research Laboratory Europe Ltd. | Date: 2012-05-04

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.


Patent
SHIMADZU RESEARCH LABORATORY EUROPE Ltd | Date: 2013-12-30

The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS)^(n )devices.

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