Shimadzu Corporation

Japan

Shimadzu Corporation

Japan
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Patent
Shimadzu Corporation | Date: 2017-01-18

The present invention is a mass spectrometer (1) for sequentially performing a measurement for a plurality of target ions, characterized by a storage section (41) for holding ion time-of-flight information concerning the time required for each of target ions to fly through each of the sections constituting the mass spectrometer, and a voltage controller (42) for changing, based on the ion time-of-flight information, the voltage applied to each of those sections to a voltage suited for each target ion, with a time lag corresponding to the difference in the timing of the arrival of the target ion at the section concerned.


Patent
Shimadzu Corporation | Date: 2017-03-29

If a scanning rate of a mass scanning is set to be high, the amount of change in an applied voltage between a time of an incidence of a certain ion into a quadrupole mass filter and a time of an emission of the ion therefrom increases. This leads to a change in the condition of a passage of ions, causing the amount of ions to decrease and thereby deteriorating detection sensitivity. In order to avoid this problem, according to the present invention, the values of direct current voltage U and an amplitude V of radio-frequency voltage, both voltages being applied to rod electrodes during a mass scanning, are respectively determined so that a voltage ratio U/V of the voltage U to the amplitude V becomes smaller as the scanning rate becomes higher. Accordingly, in a stability diagram based on the Mathieu equation, the inclination of line L indicating the change in the applied voltage during the mass scanning becomes gradual and the amount of ions passing through the quadrupole mass filter increases particularly when the mass is high.


Patent
Shimadzu Corporation | Date: 2017-03-08

In the present invention, for test cells which are either stem cells whose state of differentiation is unknown or cells obtained from stem cells by differentiation induction, an LC-MS or GC-MS analysis is performed on culture supernatants collected from a culture dish of the test cells and a culture dish of control cells whose state of differentiation is known, and the state of differentiation of the test cells is assessed based on the amount, determined as a result of the aforementioned analysis, of at least one compound selected from the group of putrescine, kynurenine, cystathionine, ascorbic acid, riboflavin, pyruvic acid, serine, cysteine, threonic acid, citric acid, and orotic acid in both the culture supernatant of the test cells and the culture supernatant of the control cells.


Patent
Shimadzu Corporation | Date: 2017-04-05

Provided is a skin external preparation including a drug and nanometer-size molecular assemblies. The molecular assemblies contain an amphiphilic block copolymer having a hydrophilic block chain including a sarcosine-derived structural unit and a hydrophobic block chain including a hydroxy acid-derived structural unit. The skin external preparation according to the present invention may reduce skin irritation caused by the drug, be very safe, and have excellent pharmacological effects, even when a drug that is generally difficult to be transdermally administered due to its strong skin irritation is contained therein.


Patent
Shimadzu Corporation | Date: 2017-02-08

An integrating sphere for a spectrometer, including: an integrating spherical body with a light entrance window for allowing an entry of light emitted from a sample, a first light detection window, and a second light detection window; a first detector attachment section located on the outside of the first light detection window; and a second detector attachment section located on the outside of the second light detection window in such a manner that the detection field of a detector to be attached to the second detector attachment section coincides with the detection field of a detector to be attached to the first detector attachment section.


Patent
Shimadzu Corporation | Date: 2017-01-11

In a mass spectrometry method for performing a qualitative and/or quantitative determination of an analyte compound contained in a sample, using a mass chromatogram acquired for one or a plurality of ions selected as a reference ion from the ions produced from the analyte compound, the present method includes the steps of: setting one or a plurality of reference-ion candidates for each of the one or a plurality of reference ions; acquiring a mass chromatogram of the sample for each of the set reference-ion candidates; calculating a shape similarity between a peak appearing at a predetermined position on the mass chromatogram and a preset model peak; and designating, as the reference ion, a reference-ion candidate corresponding to a peak having the shape similarity equal to or higher than a predetermined value.


Patent
Shimadzu Corporation | Date: 2017-02-15

A composition formula of each precursor ion located on a measured mass spectrum is estimated from the m/z value of the precursor ion (S11). A composition formula of each product ion located on a measured MS/MS spectrum is estimated from the m/z value of the product ion (S11). For each product-ion peak, the assignment of the peak is determined by verifying consistency between the composition formula of the product ion and the composition formula of each of the precursor ions (S13-S14). Based on the assignment result, the MS/MS spectrum data are separated and an MS/MS spectrum for each precursor ion is created (S 15-S16). In this manner, MS/MS spectra which respectively correspond to a plurality of compounds can be created from an MS/MS spectrum in which the product ions originating from those compounds are mixed, and those compounds can be identified.


Patent
Shimadzu Corporation and Nihon University | Date: 2017-03-22

Seat members 31 are held in a state of being movable with respect to first slide members 21 or second slide members 22 correspondingly. By rotating screws 39 in directions to increase the distances d between surfaces A of the first slide members 21 or the second slide members 22 and surfaces B of the seat members 31, chucks 25 are moved in directions to increase the distance between the chucks to apply pretension to a test piece correspondingly. When backlash in a force transmission system from a support part to the respective chucks 25 is eliminated, a biaxial tensile test is started.


Patent
Shimadzu Corporation | Date: 2017-09-27

A generation method of a digital hologram includes steps of emitting coherent light from a light source, imaging a hologram that is an interference pattern of an object beam and a reference beam due to the emission light from the light source, and setting a plurality of wavelengths of the illumination light that generates the hologram detected by the detector, and wherein the plurality of wavelength are specified by the wavelength setting step based on a magnification percentage X of a conjugate image set up by a user not to disturb visibility of an image when a real image and the conjugate image reconstructed by a predetermined calculation means relative to structures of observation targets are superimposed to a corresponding real image so that a shortest wavelength _(min) and a longest wavelength _(max) satisfy the expression _(max)/_(min) (1/X + 1).


Patent
Shimadzu Corporation | Date: 2017-09-20

Provided is a photodetector 10 including: a plurality of photoelectric conversion elements 101 arranged within a photosensitive-element area 11 constituting one photosensitive element; the plurality of detection circuits 14 each of which is provided for one of the plurality of photoelectric conversion elements 101, each of the detection circuits including a capacitor 102; and a signal processing section 19 for totaling output signals produced by the plurality of detection circuits 14.

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