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Shang Z.,Hebei University of Science and Technology | Xu L.,Hebei University of Science and Technology | Zheng L.,Shijiazhuang Pharmaceutical Group Co. | Zhang Y.,Hebei University of Science and Technology
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title compound, C26H31NO3, the octahydro-1H-isoindole ring is not planar and the two rings are twisted with a C - C - C - C torsion angle of 73.6 (4)°. The six-membered ring has a chair conformation while the five-membered ring has an envelope conformation on the C-atom in position 7a. The H atoms in the 3a- and 7a-psitions are cis and the H - C - C - H torsion angle is 42.36°. Source


Zhang L.,Chinese University of Hong Kong | Zhang L.,Hebei Medical University | Lu L.,Sun Yat Sen University | Chan W.M.,Chinese University of Hong Kong | And 3 more authors.
Neurochemical Research | Year: 2012

3-n-Butylphthalide (NBP) is a compound extracted from Chinese celery and is used as an antihypertensive herbal medicine for treating stroke patients. The aim of this study is to demonstrate the effects and mechanisms of this compound through in vitro and in vivo experiments. Culture experiments were performed by adding hydrogen peroxide (H 2O 2) to SH-SY5Y cells. From the MTT assay result, enhanced cell survival was observed with DL-NBP treatment, regardless of whether they are added before, simultaneously with or after the addition of H 2O 2. For the in vivo experiment, Spontaneously Hypertensive rats and Wistar Kyoto control rats with chronic cerebral ischemia, which were induced by bilateral transection of the common carotid arteries, were given DL-NBP. Their performances in the place navigation test and spatial probe test in the Morris Water Maze have significantly improved compared with the DL-NBP untreated animals, indicating an improvement in spatial learning and memory in the ischemic-animals. In addition, in the chick embryonic chorioallantoic membrane assay, angiogenesis was more vigorous under the effects of DL-NBP, together with increased expression of growth factors, VEGF, VEGF-receptor and bFGF. All these suggested that one of the mechanisms of DL-NBP might be ameliorating vascular dementia and promoting angiogenesis. © Springer Science+Business Media, LLC 2012. Source


Shang Z.,Hebei University of Science and Technology | Tao X.,Hebei University of Science and Technology | Ha J.,Shijiazhuang Pharmaceutical Group Co. | Yu F.,Shijiazhuang Center Hospital
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

The title pyrimidine derivative, C18H21N 3O6, was obtained by the reaction of methyl 2-[2-(benzyloxycarbonyl)aminopropan-2-yl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine- 4-carboxylate with dimethyl sulfate in dimethyl sulfoxide. The molecule has a V-shaped structure, the phenyl and the pyrimidine rings making a dihedral angle of 43.1(1)°. The methyl group substituting the pyrimidine ring deviates slightly from the ring mean-plane [C-N-C-C torsion angle = 5.49(15)°], and the methyl ester substituent has a conformation suitable for the formation of an intramolecular O-H⋯O hydrogen bond with the hydroxyl functionality. In the crystal, molecules are linked into chains along the b axis by N-H⋯O hydrogen bonds. Source


Trademark
Cspc Pharmaceutical Group Ltd. and Shijiazhuang Pharmaceutical Group Co. | Date: 2009-02-03

PHARMACEUTICAL PREPARATIONS, NAMELY A DRUG DELIVERY SYSTEM COMPRISING POLYMER-BASED ORAL TABLETS FOR THE CONTINUOUS RELEASE OF A WIDE VARIETY OF THERAPEUTIC AGENTS; PHARMACEUTICAL PREPARATIONS ACTING ON THE CENTRAL NERVOUS SYSTEM; PHARMACEUTICAL PREPARATIONS AND SUBSTANCES FOR THE TREATMENT OF GASTRO-INTESTINAL DISEASES; PHARMACEUTICAL PREPARATIONS FOR OCULAR OR INTRAOCULAR SURGERY; PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF HORMONAL DISORDERS AND THE PREVENTION OF OSTEOPOROSIS; PHARMACEUTICAL PREPARATIONS FOR TREATING ALLERGIC RHINITIS AND ASTHMA; PHARMACEUTICAL PREPARATIONS FOR TREATING DIABETES; PHARMACEUTICAL PREPARATIONS FOR USE IN UROLOGY; PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF EYE DISEASES AND CONDITIONS; PHARMACEUTICAL PREPARATIONS FOR THE PREVENTION AND TREATMENT OF DISORDERS OF THE NERVOUS SYSTEM, THE IMMUNE SYSTEM, THE CARDIO-VASCULAR SYSTEM, THE METABOLIC SYSTEM, THE RESPIRATORY SYSTEM, THE MUSCULO-SKELETAL SYSTEM, THE GENITOURINARY SYSTEM; FOR THE TREATMENT OF INFLAMMATORY DISORDERS; FOR USE IN DERMATOLOGY, ONCOLOGY, HEMATOLOGY AND IN TISSUE AND ORGAN TRANSPLANTATION, IN OPHTHALMOLOGY AND FOR GASTROENTEROLOGICAL DISORDERS; PHARMACEUTICAL PREPARATIONS FOR THE PREVENTION AND TREATMENT OF OCULAR DISORDERS OR DISEASES, FOR THE TREATMENT OF BACTERIA-BASED DISEASES, AND FOR THE TREATMENT OF DIABETES, AND ANTI-INFECTIVE PREPARATIONS, ANTIVIRAL PREPARATIONS, ANTIBIOTICS, ANTIFUNGAL PREPARATIONS AND VACCINES; MIXED VITAMIN PREPARATIONS; MULTI-VITAMIN PREPARATIONS; VITAMIN AND MINERAL PREPARATIONS FOR MEDICAL USE; VITAMIN B PREPARATIONS, VITAMIN C PREPARATIONS; VITAMIN D PREPARATIONS; VITAMINS AND VITAMIN PREPARATIONS; ANALGESICS; DIETETIC FOODS ADAPTED FOR MEDICAL USE; NUTRITIONAL ADDITIVES FOR MEDICAL PURPOSES FOR USE IN FOODS AND DIETARY SUPPLEMENTS FOR HUMAN CONSUMPTION; TRANQUILIZERS; BIOCHEMICAL PREPARATIONS FOR MEDICAL OR VETERINARY PURPOSES; DIAGNOSTIC PREPARATIONS FOR MEDICAL AND VETERINARY USE; MEDICINAL DRINKS; DIET PILLS, SLEEPING PILLS, ANTIBIOTICS; BIOLOGICAL PREPARATIONS FOR MEDICAL PURPOSES.


Cao Y.-X.,Tianjin University | Qiao B.,Tianjin University | Lu H.,Hebei Zhongrun Pharmaceutical Co. | Lu H.,Shijiazhuang Pharmaceutical Group Co. | And 3 more authors.
Applied Microbiology and Biotechnology | Year: 2011

The disparity of secondary metabolites in Penicillium chrysogenum between two scales of penicillin G fermentation (50 L as pilot process and 150,000 L as industrial one) was investigated by ion-pair reversed-phase liquid chromatography tandemed with hybrid quadrupole time-of-flight mass spectrometry. In industrial process, the pools of intracellular L-α-aminoadipyl-L- cysteinyl-D-valine (LLD-ACV) and isopenicillin N (IPN) were remarkably less than that in the pilot one, which indicated that the productivity of penicillin G might be higher in the large scale of fermentation. This conclusion was supported by the higher intracellular penicillin G concentration as well as its higher yield per unit biomass in industrial cultivation. The different changing tendencies of IPN, 6-aminopenicillanic acid and 6-oxopiperide-2-carboxylic acid between two processes also suggested the same conclusion. The higher content of intracellular LLD-ACV in pilot process lead to a similarly higher concentration of bis-δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine, which had an inhibitory effect on ACV synthetase and also subdued the activity of IPN synthetase. The interconversion of secondary metabolites and the influence they put on enzymes would intensify the discrepancy between two fermentations more largely. These findings provided new insight into the changes and regulation of secondary metabolites in P. chrysogenum under different fermentation sizes. © 2011 Springer-Verlag. Source

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