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Shijiazhuang, China

Fan J.,Beijing University of Technology | Fan J.,Hebei University of Science and Technology | Jia S.,Beijing University of Technology | Li X.,Beijing University of Technology | And 4 more authors.
2011 IEEE International Conference on Mechatronics and Automation, ICMA 2011 | Year: 2011

With the increase in the number of senior citizens and disabled persons, there is a growing demand for human-friendly wheelchairs as mobility aids. Wheelchair is often controlled by hands via joysticks, so it is inconvenient and difficult for persons in wheelchairs to play sports. To solve this problem, this paper presents a method of motion control based on sitting postures, including direction and speed hand-free control. The high-speed analog data acquisition system provides enough information according to the sitting postures of the wheelchair users, where four force sensors are installed under the seat. The intelligent wheelchair control system will calculate gravity centre of human body and decide to move in which direction and provide proper speed to control the motors. At the same time, it shows the dynamic moving directions and creates a real time path map of the intelligent wheelchair to guide the users. This control mode will give the disabled or the wheelchair athletes more opportunities not only for sports, but also for some other everyday work. The results of experiments and simulations indicate that this intelligent wheelchair control system effectively provides mobility and autonomy to the target population. © 2011 IEEE.

Fan J.,Beijing University of Technology | Fan J.,Hebei University of Science and Technology | Jia S.,Beijing University of Technology | Lu W.,Shijiazhuang Medical College | And 3 more authors.
Proceedings - 2011 IEEE International Conference on Computer Science and Automation Engineering, CSAE 2011 | Year: 2011

In industry field, common A/D converter chips are widely used for low-speed analog data acquisition. Most of common A/D converter chips are not fit for the requirements of high-speed vary analog signal. This paper presents a high-speed data acquisition system which interface and algorithm are programmed in Delphi 7.0. The design is based on PCI-1716 card is proposed for LVDT sensor detection and realized the high-speed analogical data acquisition of multichannel sensor analog signals in the method of software polling mode. The measured results of application indicate that the measurement precision can reaches 0.01 mm, and this system has good commonality as well as extensibility. © 2011 IEEE.

Fan J.,Beijing University of Technology | Fan J.,Hebei University of Science and Technology | Jia S.,Beijing University of Technology | Li X.,Beijing University of Technology | Lu W.,Shijiazhuang Medical College
IET Conference Publications | Year: 2012

A large number of wheelchairs are manipulated via joysticks. But for the different degree of the handicapped, joystick does not fit for any disabled person and it will limit the users' hand behaviour, especially in sport for them. This paper elaborates a more effective and hands-free method to control the intelligent wheelchair (IW), and describes the details of control algorithm on the omni-directional platform. The algorithm controls the IW's directions and velocities according to user's different sitting postures. Using the information from the force sensors under the seat surface, the different 2D position of gravity centre will be calculated out to control the intelligent wheelchair in response to the user's leaning in different directions and velocities. Furthermore, it describes the motion mathematical model of the omnidirectional wheelchair platform and provides control system hardware structure as well. Experiment results eventually indicate that the sitting postures control function is realized accurately, effectively in directions and velocities.

Yan W.,Hebei Medical University | Yan W.,Shijiazhuang Medical College | Kang J.,Hebei Medical University | Zhang G.,Hebei Medical University | And 4 more authors.
Neuroscience Letters | Year: 2015

Binge drinking ethanol exposure during adolescence can lead to long-term neurobehavioural damage. It is not known whether the pubertal surge in testosterone that occurs during adolescence might impact the neurobehavioural effects of early ethanol exposure in adult animals. We examined this hypothesis by performing sham or gonadectomy surgeries on Sprague-Dawley rats around postnatal day (P) 23. From P28-65,the rats were administered 3.0. g/kg ethanol using a binge-like model of exposure. Dependent measurements included tests of open field behaviour, blood ethanol concentrations, and testosterone levels. As adults, significant decreases in open field activity were observed in the GX rats. The open field behaviour of the GX rats was restored after testosterone administration. Binge-like ethanol exposure altered most of the parameters of the open field behaviour, suggestive of alcohol-induced anxiety, but rats treated with alcohol in combination with gonadectomy showed less motor behaviour and grooming behaviour and an increase in immobility, suggesting ethanol-induced depression. These results indicated that testosterone is required for ethanol-induced behavioural changes and that testicular hormones are potent stimulators of ethanol-induced behaviours. © 2015 Elsevier Ireland Ltd.

Xia P.,Shenyang Medical College | Mou F.-F.,Shijiazhuang Medical College | Wang L.-W.,CAS Tianjin Institute of Biomedical Engineering
Asian Pacific Journal of Cancer Prevention | Year: 2012

Non-small-cell lung cancer (NSCLC) is a leading cause of cancer deaths worldwide. Crizotinib has been approved by the U.S. Food and Drug Administration for the treatment of patients with advanced NSCLC. However, understanding of mechanisms of action is still limited. In our studies, we confirmed crizotinib-induced apoptosis in A549 lung cancer cells. In order to assess mechanisms, small molecular docking technology was used as a preliminary simulation of signaling pathways. Interesting, our results of experiments were consistent with the results of computer simulation. This indicates that small molecular docking technology should find wide use for its reliability and convenience.

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