Shijiazhuang Medical College

Shijiazhuang, China

Shijiazhuang Medical College

Shijiazhuang, China

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Kang Y.,Hebei Medical University | Yan W.,Hebei Medical University | Yan W.,Shijiazhuang Medical College | Fang H.,Hebei Medical University | And 5 more authors.
Oxidative Medicine and Cellular Longevity | Year: 2017

The current studies were aimed at evaluating the efficacy of intranasal pentoxifylline (Ptx) pretreatment in protecting mesodopaminergic system and hippocampus from oxidative damage of lithium-pilocarpine induced status epilepticus (SE) and the involvement of nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response elements pathway. Pentoxifylline was administered to rats intranasally or intraperitoneally 30 minutes before inducing SE. Our results showed the impaired visuospatial memory, the defected mesodopaminergic system, and the oxidative damage and the transient activation of Nrf2 in SE rats. The transient activation of Nrf2 in SE rats was enhanced by Ptx pretreatment, which was followed by the upregulation of heme oxygenase-1 and NAD(P)H:quinone oxidoreductase-1. Ptx pretreatment to SE rats significantly suppressed the epileptic seizures, decreased the levels of lipid peroxide and malondialdehyde, and elevated the ratio of reduced glutathione/oxidized glutathione. Compared with intraperitoneal injection, intranasal Ptx delivery completely restored the visuospatial memory and the activity of mesodopaminergic system in SE rats. Intranasal administration of Ptx may hopefully become a noninvasive, painless, and easily administered option for epileptic patients. © 2017 Yunxiao Kang et al.


Wang Y.,Jilin University | Wang Y.,Changchun University of Chinese Medicine | Wang L.,Shijiazhuang Medical College | Hu Y.,Changchun University of Chinese Medicine | And 2 more authors.
Natural Product Research | Year: 2010

In this study, cholest-5-en-3,7-diol (1) and 3-hydroxy-cholest-5-en-7-one (2) were isolated from Oviductus Ranae by column chromatographies on Sephadex LH-20, octadecylsilyl (ODS) and pre high-performance liquid chromatography (HPLC). Their structures were elucidated on the basis of chemical and spectral analyses, including electrospray ionisation-mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR). The above two compounds were obtained from Oviductus Ranae for the first time. © 2010 Taylor & Francis.


Zhou Y.-N.,Hebei Medical University | Zhang H.,Shijiazhuang Medical College | Chen X.-C.,Shijiazhuang Medical College | Yan Z.-P.,Shijiazhuang Medical College | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: To overcome the disadvantages of traditional mechanical analysis of specimens, and establish the finite element model of realistic foot, are the important basements for the finite element mechanical analysis on foot. OBJECTIVE: To establish three-dimensional finite element model of foot and lay the foundation for the finite element analysis of normal foot and foot injury. METHODS: A healthy female volunteer was involved in this study and was detected with spiral CT scanning on the feet. The resulting image was used to reconstruct the three-dimensional model by using Mimics software. Then entity model was generated in Geomagic software. Finally three-dimensional finite element model was established based on the digital main structure in Ansys. RESULTS AND CONCLUSION: The established finite element digital model of human foot included all bone, cartilage and ligament, skin and soft tissue. The three-dimensional finite element model of human foot was established based on CT data and using Mimics, Geomagic, Ansys softwares. The established model had similar size and shape with skeletal mode, and can rotate freely in any angle for a variety of measurement, the foot bones can be arbitrarily split or merge, which is suitable for biomechanical analysis. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Yan W.,Hebei Medical University | Yan W.,Shijiazhuang Medical College | Kang J.,Hebei Medical University | Zhang G.,Hebei Medical University | And 4 more authors.
Neuroscience Letters | Year: 2015

Binge drinking ethanol exposure during adolescence can lead to long-term neurobehavioural damage. It is not known whether the pubertal surge in testosterone that occurs during adolescence might impact the neurobehavioural effects of early ethanol exposure in adult animals. We examined this hypothesis by performing sham or gonadectomy surgeries on Sprague-Dawley rats around postnatal day (P) 23. From P28-65,the rats were administered 3.0. g/kg ethanol using a binge-like model of exposure. Dependent measurements included tests of open field behaviour, blood ethanol concentrations, and testosterone levels. As adults, significant decreases in open field activity were observed in the GX rats. The open field behaviour of the GX rats was restored after testosterone administration. Binge-like ethanol exposure altered most of the parameters of the open field behaviour, suggestive of alcohol-induced anxiety, but rats treated with alcohol in combination with gonadectomy showed less motor behaviour and grooming behaviour and an increase in immobility, suggesting ethanol-induced depression. These results indicated that testosterone is required for ethanol-induced behavioural changes and that testicular hormones are potent stimulators of ethanol-induced behaviours. © 2015 Elsevier Ireland Ltd.


Fan J.,Beijing University of Technology | Fan J.,Hebei University of Science and Technology | Jia S.,Beijing University of Technology | Li X.,Beijing University of Technology | And 4 more authors.
2011 IEEE International Conference on Mechatronics and Automation, ICMA 2011 | Year: 2011

With the increase in the number of senior citizens and disabled persons, there is a growing demand for human-friendly wheelchairs as mobility aids. Wheelchair is often controlled by hands via joysticks, so it is inconvenient and difficult for persons in wheelchairs to play sports. To solve this problem, this paper presents a method of motion control based on sitting postures, including direction and speed hand-free control. The high-speed analog data acquisition system provides enough information according to the sitting postures of the wheelchair users, where four force sensors are installed under the seat. The intelligent wheelchair control system will calculate gravity centre of human body and decide to move in which direction and provide proper speed to control the motors. At the same time, it shows the dynamic moving directions and creates a real time path map of the intelligent wheelchair to guide the users. This control mode will give the disabled or the wheelchair athletes more opportunities not only for sports, but also for some other everyday work. The results of experiments and simulations indicate that this intelligent wheelchair control system effectively provides mobility and autonomy to the target population. © 2011 IEEE.


Fan J.,Beijing University of Technology | Fan J.,Hebei University of Science and Technology | Jia S.,Beijing University of Technology | Lu W.,Shijiazhuang Medical College | And 3 more authors.
Proceedings - 2011 IEEE International Conference on Computer Science and Automation Engineering, CSAE 2011 | Year: 2011

In industry field, common A/D converter chips are widely used for low-speed analog data acquisition. Most of common A/D converter chips are not fit for the requirements of high-speed vary analog signal. This paper presents a high-speed data acquisition system which interface and algorithm are programmed in Delphi 7.0. The design is based on PCI-1716 card is proposed for LVDT sensor detection and realized the high-speed analogical data acquisition of multichannel sensor analog signals in the method of software polling mode. The measured results of application indicate that the measurement precision can reaches 0.01 mm, and this system has good commonality as well as extensibility. © 2011 IEEE.


Xia P.,Shenyang Medical College | Mou F.-F.,Shijiazhuang Medical College | Wang L.-W.,CAS Tianjin Institute of Biomedical Engineering
Asian Pacific Journal of Cancer Prevention | Year: 2012

Non-small-cell lung cancer (NSCLC) is a leading cause of cancer deaths worldwide. Crizotinib has been approved by the U.S. Food and Drug Administration for the treatment of patients with advanced NSCLC. However, understanding of mechanisms of action is still limited. In our studies, we confirmed crizotinib-induced apoptosis in A549 lung cancer cells. In order to assess mechanisms, small molecular docking technology was used as a preliminary simulation of signaling pathways. Interesting, our results of experiments were consistent with the results of computer simulation. This indicates that small molecular docking technology should find wide use for its reliability and convenience.


Fan J.,Beijing University of Technology | Fan J.,Hebei University of Science and Technology | Jia S.,Beijing University of Technology | Li X.,Beijing University of Technology | Lu W.,Shijiazhuang Medical College
IET Conference Publications | Year: 2012

A large number of wheelchairs are manipulated via joysticks. But for the different degree of the handicapped, joystick does not fit for any disabled person and it will limit the users' hand behaviour, especially in sport for them. This paper elaborates a more effective and hands-free method to control the intelligent wheelchair (IW), and describes the details of control algorithm on the omni-directional platform. The algorithm controls the IW's directions and velocities according to user's different sitting postures. Using the information from the force sensors under the seat surface, the different 2D position of gravity centre will be calculated out to control the intelligent wheelchair in response to the user's leaning in different directions and velocities. Furthermore, it describes the motion mathematical model of the omnidirectional wheelchair platform and provides control system hardware structure as well. Experiment results eventually indicate that the sitting postures control function is realized accurately, effectively in directions and velocities.


PubMed | Shijiazhuang Medical College and Tianjin Medical University
Type: | Journal: The International journal of neuroscience | Year: 2016

Little is known about patients with neuromyelitis optica spectrum disorders (NMOSD) as defined by onset age. This study aimed to analyze the different demographic, clinical, laboratory, and magnetic resonance imaging (MRI) characteristics in early-onset (50 years) NMOSD (EONMOSD) and late-onset (>50 years) NMOSD (LONMOSD).We enrolled 142 patients with NMOSD from Tianjin Medical University General Hospital, Tianjin, China, and categorized them into two groups according to the age of onset: EONMOSD and LONMOSD. Demographic, clinical, laboratory, and MRI characteristics were collected and compared between the two groups. Serum aquaporin-4 (AQP4) antibody levels were determined by cell-based assay and fluorescence immunoprecipitation assays.Among the patients studied, 83 had early onset (50 years) and 59 had late onset (>50 years) of NMOSD. As compared with LONMOSD, EONMOSD patients had more severe visual disability according to functional scores in clinical parameters, significantly lower C3 and C4 serum levels, more frequent cervical lesions, and more lesions around the fourth ventricle, but fewer lesions in hemispheric white matter. LONMOSD patients suffered more motor and sensory disability than EONMOSD patients.In NMOSD, the clinical, laboratory, and MRI features differ according to age of onset, suggesting that differences in pathogenesis and treatment should be further investigated.

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