Otsu-shi, Japan

Shiga University of Medical Science is a national university in Ōtsu, Shiga, Japan, founded in 1974. Wikipedia.


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Patent
Shiga University of Medical Science | Date: 2015-03-17

The inventions disclosed herein are a method for quantifying cardiolipin in a sample, comprising the steps of: (1) treating the sample with phospholipase D, glycerol kinase, glycerol-3-phosphate oxidase, and peroxidase and (2) measuring the fluorescence intensity, absorbance, or luminescence intensity of a compound generated in step (1) to quantify cardiolipin using a calibration curve obtained beforehand; and a kit for quantifying cardiolipin comprising phospholipase D, glycerol kinase, glycerol-3-phosphate oxidase, and peroxidase.


Patent
Ehime University, Shiga University of Medical Science and Yokohama City University | Date: 2015-11-04

Provided in the present invention is a genetic marker including a SNP which can be used for assessing the risk of developing hypertension, a polynucleotide for assessing the risk of developing hypertension which can be used as a primer or probe for detecting the genetic marker, a method for assessing the risk of developing hypertension using the SNP, a microarray for assessing the risk of developing hypertension which is used for genotyping of the SNP, a kit used in the method for assessing the risk of developing hypertension, and the like.


Patent
Ehime University, Shiga University of Medical Science and Yokohama City University | Date: 2015-10-28

Provided in the present invention is a genetic marker including a SNP which can be used for assessing the risk of developing hypertension, a polynucleotide for assessing the risk of developing hypertension which can be used as a primer or probe for detecting the genetic marker, a method for assessing the risk of developing hypertension using the SNP, a microarray for assessing the risk of developing hypertension which is used for genotyping of the SNP, a kit used in the method for assessing the risk of developing hypertension, and the like.


Modification of serine and threonine residues in proteins by O-linked β-N-acetylgulcosamine (O-GlcNAc) glycosylation is a feature of many cellular responses to the nutritional state and to stress. O-GlcNAc modification is reversibly regulated by O-linked β-N-acetylgulcosamine transferase (OGT) and β-D-N-acetylgulcosaminase (O-GlcNAcase). O-GlcNAc modification of proteins is dependent on the concentration of uridine 5′-diphospho-N-acetylgulcosamine (UDP-GlcNAc), which is a substrate of OGT and is synthesized via the hexosamine biosynthetic pathway. Immunoblot analysis using the O-GlcNAc-specific antibody CTD110.6 has indicated that glucose deprivation increases protein O-GlcNAcylation in some cancer cells. The mechanism of this paradoxical phenomenon has remained unclear. Here we show that the increased glycosylation induced by glucose deprivation and detected by CTD110.6 antibodies is actually modification by N-GlcNAc2, rather than by O-GlcNAc. We found that this induced glycosylation was not regulated by OGT and O-GlcNAcase, unlike typical O-GlcNAcylation, and it was inhibited by treatment with tunicamycin, an N-glycosylation inhibitor. Proteomics analysis showed that proteins modified by this induced glycosylation were N-GlcNAc2-modified glycoproteins. Furthermore, CTD110.6 antibodies reacted with N-GlcNAc2-modified glycoproteins produced by a yeast strain with a ts-mutant of ALG1 that could not add a mannose residue to dolichol-PP-GlcNAc2. Our results demonstrated that N-GlcNAc2-modified glycoproteins were induced under glucose deprivation and that they cross-reacted with the O-GlcNAc-specific antibody CTD110.6. We therefore propose that the glycosylation status of proteins previously classified as O-GlcNAc-modified proteins according to their reactivity with CTD110.6 antibodies must be re-examined. We also suggest that the repression of mature N-linked glycoproteins due to increased levels of N-GlcNAc2-modifed proteins is a newly recognized pathway for effective use of sugar under stress and deprivation conditions. Further research is needed to clarify the physiological and pathological roles of N-GlcNAc2-modifed proteins. © 2011 Takahiro Isono.


Patent
Panasonic and Shiga University of Medical Science | Date: 2014-12-03

Disclosed herein is a method for diagnosing Alzheimers disease capable of minimizing invasiveness to reduce the risk of infection. The method for diagnosing Alzheimers disease includes the steps of: pretreating an intranasal specimen; detecting tau protein or amyloid beta peptide (A) in the pretreated intranasal specimen; comparing a value of the tau protein or the A obtained in the detection step with a predetermined value; and displaying a comparison result obtained in the comparison step.


Patent
Shiga University of Medical Science | Date: 2015-11-18

Disclosed is a compound represented by formula (1) or a salt thereof, formula (1) :^(1) and R^(2) are each independently a hydrogen atom, a fluorine atom, methyl, or trifluoromethyl; R^(3) is trifluoromethyl or trifluoromethoxy; and p is an integer of 1 to 4, provided that m + n 5 when J is J-1, and m + n 7 when J is J-2 or J-3.


Patent
Shiga University of Medical Science | Date: 2014-01-06

Disclosed is a compound represented by formula (1) or a salt thereof, formula (1): wherein X is a residue of a compound having activity of binding to at least one member selected from the group consisting of amyloid proteins, tau proteins, -synuclein, and TDP-43; m is an integer of 0 to 6; n is an integer of 1 to 5; and J is a group selected from the group consisting of wherein R^(1 )and R^(2 )are each independently a hydrogen atom, a fluorine atom, methyl, or trifluoromethyl; R^(3 )is trifluoromethyl or trifluoromethoxy; and p is an integer of 1 to 4, provided that m+n5 when J is J-1, and m+n7 when J is J-2 or J-3.


Patent
Shiga University of Medical Science | Date: 2015-03-25

It is an object to provide a surgical tool for excising a hard solid organ such as cirrhotic liver or cutting the organ into a groove without causing bleeding. The inventors of the present invention have found that an organ resection tool including a brush-like structure capable of performing microwave irradiation and/or a brush-like structure capable of receiving a microwave can achieve the above-mentioned object, to thereby arrive at the present invention (organ resection tool including a brush structure capable of performing microwave irradiation). For example, an organ can be crushed or scraped away by manually abrading the organ with a brush of a solid organ resection tool including a brush structure capable of performing microwave irradiation according to the present invention. Further, the organ can be concurrently coagulated through the microwave irradiation to stop bleeding.


Patent
Shiga University of Medical Science | Date: 2014-10-22

Provided is a surgical instrument that is substitutable for an operation of placing each stitch with a threaded needle or a stapler. It is confirmed that, in a tissue suturing device including a crushing section, and a projecting section including a central conductor and/or an external conductor for applying a microwave, the projecting section and the crushing section bring fragmentary portions of tissues to be sutured into contact or overlap with each other, and coagulate and/or fix contact or overlap portions with the microwave, to thereby stitch the tissues to be sutured.


Patent
Shiga University of Medical Science | Date: 2014-06-18

It is an object to provide a surgical instrument capable of locally applying microwaves to a minute biological tissue. It has been found that microwaves can be transmitted to a tip of a tapered coaxial body (9) and that microwaves are radiated from the entire central conductor exposed in a major axis direction by decreasing a sectional area (preferably diameter) of a central conductor (1) and a sectional area (preferably inner diameter) of an external conductor gradually or in a step-by-step manner with a ratio between the sectional area (diameter) of the central conductor (1) and the sectional area (inner diameter) of the external conductor being set to be constant, thereby achieving the present invention.

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