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Keshorai Pātan, India

Patel P.S.,Sheth Lh Science College | Shah R.A.,Sheth Lh Science College | Trivedi D.K.,Sheth Lh Science College | Vyas P.J.,Sheth Lh Science College | Vyas P.J.,Sheth Mn Science College
Oriental Journal of Chemistry | Year: 2010

4-{4-(2-methyl-4-benzylidene-5-oxo-imidazol-1-yl)phenyl} -6-(substitutedphenyl)-5,6dihydropyrimidin-2-one have been prepared by the refluxation for 3 hours of 4-benzylidene-1-{4-[3(substitutedphenyl)prop-2-enoyl] phenyl)-2-methyl-imidazol-5-one with urea and potassium hydroxide in presence of ethanol. The intermidiate 4-benzylidene-1 -{4-{3-(substitutedphenyl)prop-2- enoyl]phenyl}2-methyl-imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-benzylidene-2methyl-3,5-dihydro-imidazol-5-one with various aldehydes. Source


Parikh K.S.,Sheth Mn Science College | Vyas S.P.,Sheth Mn Science College
Journal of Applied Pharmaceutical Science | Year: 2012

4,6-dimethoxypyrimidin-2-amine condensed with trichloro s-triazine. The product of the above reaction was allowed to react with Morpholine. Finally various aromatic amines derivatives were allowed to react and the product were characterized by conventional and instrumental methods. Their structures were determined and important biological properties were studied. Source


Patel R.M.,Sheth Mn Science College | Parikh K.S.,Sheth Mn Science College | Patel K.N.,Science College
International Journal of ChemTech Research | Year: 2010

Thiosemicarbazone compounds are established as selective and sensitive analytical reagents for the detection and determination of transition metals. In the present work, 2-hydroxy-4-n-butoxy-5-bromopropiophenone thiosemicarbazone (HBBrPT) is described as an extractive spectrophotometric reagent for nickel. The method is based on formation of Ni (II)-HBBrPT complex, which is extractable in benzene from the aqueous solution by shaking for 1-2 min. HBBrPT have been developed as new chromogenic reagent for the rapid spectrophotometric determination of micro quantities of nickel. The solid complex have been isolated and characterized on the basis of elemental analysis, and UV, IR, NMR and Mass spectra. The absorbance measured at 440 nm and the molar absorptivity is 3638 L.mol -1.cm -1. The complex system confirms the Beers law up to 14.67 μg/ml. Optimum concentration range was found to be 4.40-10.27 μg/ml of Ni (II) whereas the sandell's sensitivity was found 0.01613 μg cm -2. The experimental conditions for the complete colour development and the interference from various ions are investigated. HBBrPT is found to be a selective and strong chelating agent for nickel. The results deduced from Jobs method of continuous variation, the mole ratio and the slope ratio method showed that metal: ligand ratio in the complex to be 1:2. The stability constant of the complex found to be 6.41X 10 8. The free energy change for the complex formation reaction is found to be -12.291 K cal/mole at 30° C. The complex is fairly stable for about 24 h. and up to 45° C. The newly developed method is used for the determination of nickel in its complexes and synthetic mixtures as well as industrial effluents and alloy samples. From the statistical evaluation of data, it was generalized that the method is quite precise and accurate for the spectrophotometric determination of nickel. The statistical data evaluation showed that the method is quite precise and accurate for the spectrophotometric determination of nickel. Various commercial samples and synthetic mixtures containing Ni (II) were analyzed according to the recommended procedure and the results were compared to those obtained by standard method. It was observed that the proposed method is satisfactory in all the cases. Source


Gadape H.H.,Sheth Mn Science College | Parikh K.S.,Sheth Mn Science College
E-Journal of Chemistry | Year: 2011

Rapid, specific and accurate proton nuclear magnetic resonance spectroscopy (1H NMR) method was developed to determine metformin hydrochloride antidiabetic drug in pharmaceutical tablet formulation. The method was based on quantitative NMR spectroscopy (qNMR) using maleic acid as an internal standard and deuterium oxide (D2O) as a diluent. For the quantification of the drug, the 1H NMR signals at 2.91 ppm and 6.25 ppm corresponding to the analyte proton of metformin hydrochloride and maleic acid internal reference standard (IS) respectively were used. The method was validated for the parameters of specificity and selectivity, precision and intermediate precision, linearity, range, limit of detection (LOD) and limit of quantification (LOQ), accuracy, solution stability and robustness. The linearity of the calibration curve for analyte in the desired concentration range was good (R 2=0.9993). The method was accurate and precise with good recoveries. Range study was also performed up to saturation level (152.67 mg/0.60 mL) in D2O. The advantage of the method is that no reference standard of analyte drug is required for quantification. The method is nondestructive and can be applied for quantification of metformin hydrochloride in commercial formulation products. Source


Parikh K.S.,Sheth Mn Science College | Patel R.M.,Sheth Mn Science College | Patel K.N.,Sheth Mn Science College | Patel K.N.,P.A. College
Asian Journal of Chemistry | Year: 2010

A simple, sensitive and specific spectrophotometric method has been developed for the determination of iron(II) in benzene. The metal ion reacts with 2-hydroxy-4-n-butoxy-5-bromo propiophenone thiosemicarbazone (HBBrPT) forming a dark red coloured complex in the pH range 5.0-9.0. The complex shows maximum absorption at 470 nm. Beer's law is obeyed in the range 13.96 μg/mL. The molar absorptivity and Sandell's sensitivity are found to be 2845 L mol -1 cm -1 and 0.01962 μg cm-2, respectively. The solid complex have been isolated and characterized on the basis of elemental analysis, UV, IR, NMR and mass spectra. 2-Hydroxy-4-n-butoxy-5-bromo propiophenone thiosemicarbazone is found to be a selective and strong chelating agent for iron. The results deduced from Job's method of continuous variation, the mole ratio and the slope ratio method showed that metal: ligand ratio in the complex to be 1:2. The stability constant of the complex found to be 1.22 × 10 7. The free energy change for the complex formation reaction is found to be-9.989 K cal/mol at 35°C. The complex is fairly stable for about 24 h and up to 55°C. Source

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