Robins-Steele S.,University of Toronto |
Robins-Steele S.,Sheridan Institute of Technology and Advanced Learning |
Nguyen D.H.,Western Research Institute |
Nguyen D.H.,University of Manitoba |
Fehlings M.G.,Toronto Western Hospital
Journal of Neurotrauma | Year: 2012
Spinal cord injury (SCI) is a devastating condition that currently lacks clinically-relevant and effective neuroprotective therapeutic options. Optimal therapeutic agents for clinical translation should show efficacy in a cervical compression/contusion model using a clinically-relevant post-injury therapeutic time window. To date, few compounds have met that rigorous standard. The objective of this work was to evaluate the efficacy of delayed post-injury administration of soluble Fas receptor (sFasR) via intrathecal catheter following acute cervical SCI in a clinically-relevant contusion/compression model. Female Wistar rats were given a C7-T1 moderately severe clip compression injury, followed by either 8-h or 24-h delayed treatment initiation. Long-term neurobehavioral analysis of motor recovery and neuropathic pain development was undertaken. The extent of oligodendrocyte and neuron survival was assessed in peri-lesional cord sections 8 weeks post-SCI. This was complemented by an evaluation of the level of tissue preservation at and adjacent to the site of injury. In animals treated with sFasR delayed 8 h post-injury, significant behavioral effects were observed, coinciding with enhanced cell survival, peri-lesional tissue sparing, and enhanced integrity of descending fiber tracts compared to control treatments. Animals treated with sFasR delayed by 24 h showed more modest improvements in behavioral recovery, and had consistent improvements in cell survival and tissue preservation. This work has shown for the first time that the Fas-mediated apoptotic pathway can be therapeutically targeted in a clinically-relevant time window post-SCI. © Mary Ann Liebert, Inc. 2012.
Grolinger K.,University of Western Ontario |
Capretz M.A.M.,University of Western Ontario |
Cunha A.,Sheridan Institute of Technology and Advanced Learning |
Tazi S.,Hoffmann-La Roche |
Tazi S.,Toulouse 1 University Capitole
Service Oriented Computing and Applications | Year: 2014
A significant challenge in business process automation involves bridging the gap between business process representations and Web service technologies that implement business activities. We are interested in business process representations such as Business Process Modeling Notation (BPMN) and Event-Driven Process Chains (EPCs). Web service technologies include protocols such as Simple Object Access Protocol (SOAP), architectures such as REpresentational State Transfer (RESTful), or semantic description languages and formalisms such as Web Ontology Language for Services (OWL-S) and Web Service Modeling Ontology (WSMO). This paper reviews previous work on the integration of business process representations and Web service technologies. It provides a perspective on the field by summarizing, organizing, and classifying the proposed approaches. Consequently, this study has identified opportunities for future research in the field, including the need for a generic transformation approach among arbitrary models, the need to represent mappings in a formalized way, and the necessity of a common execution framework. © 2013 Springer-Verlag London.
Hu S.Y.,University of Waterloo |
Zhang Y.,Tianjin Polytechnic University |
Lawless D.,Sheridan Institute of Technology and Advanced Learning |
Feng X.,University of Waterloo
Journal of Membrane Science | Year: 2012
Composite membranes comprising of a separating layer of polyvinylamine (PVAm)-poly(vinyl alcohol) (PVA) incorporated with carbon nanotubes (CNTs) supported on a microporous polysulfone substrate were fabricated for the dehydration of ethylene glycol by pervaporation. The material aspects of the membranes were characterized with Fourier transform infrared (FTIR), Raman spectroscopy, X-ray diffraction (XRD), contact angle measurement and water sorption uptake, using dense films of PVAm-PVA/CNTs, to determine the effects of CNTs on the intermolecular interactions, degree of crystallinity, surface hydrophilicity, and degrees of swelling of the PVAm-PVA/CNT membranes. The effects of feed water concentration, temperature and CNT content in the membrane on the separation performance were investigated. The incorporation of CNTs into the membrane was shown to increase the permeation flux and separation factor, and the improvement in the separation performance was particularly significant at low feed water concentrations. At a feed water concentration of 1wt%, a permeation flux of 146g/(m 2h) and a separation factor of 1160 were achieved at 70°C using a PVAm-PVA/CNT membrane containing 2wt% of CNTs. © 2012 Elsevier B.V.
Heather Fritzley V.,Queen's University |
Heather Fritzley V.,Sheridan Institute of Technology and Advanced Learning |
Lindsay R.C.L.,Queen's University |
Lindsay R.C.L.,Sheridan Institute of Technology and Advanced Learning |
And 2 more authors.
Child Development | Year: 2013
Two experiments investigated response tendencies of preschoolers toward yes-no questions about actions. Two hundred 2- to 5-year-old children were asked questions concerning actions commonly associated with particular objects (e.g., drinking from a cup) and actions not commonly associated with particular objects (e.g., kicking a toothbrush). The impact of delay and comprehension of questions were also investigated. Results revealed a consistent developmental transition: Younger children tended to display a yes bias whereas older children did not display a bias unless they faced incomprehensible questions, in which case they displayed a nay-saying bias. Delay shifted children's responses in such a way that "no" answers were given more often. These findings hold important implications regarding the use of yes-no questions with children. © 2012 Society for Research in Child Development, Inc.
Sykes E.R.,Sheridan Institute of Technology and Advanced Learning
Procedia Computer Science | Year: 2014
The number of interruptions people experience on a daily basis has grown considerably over the last decade and this growth has not shown any signs of subsiding. In fact, with the In this work, an architecture for a cloud-based interruption management system for mobile device users is presented. The system draws from rich contextual information from the mobile device (i.e., user, task and environment dimensions) and real-time observations of the user's activities and then reasons about ideal times to interact with the user. The reasoning component (interruption algorithm) is situated in the cloud and implemented using a novel machine learning technique (an Adaptive Neuro Fuzzy Inference System). This research addresses the complex problem of determining the precise time to interact with a mobile device user and in so doing aims to reduce the negative aspects of interruptions. This paper also presents a new interruption taxonomy built on an existing framework, and a report on the current prototype developed. © 2014 Elsevier B.V.
Sykes E.R.,Sheridan Institute of Technology and Advanced Learning |
Lin M.,Sheridan Institute of Technology and Advanced Learning |
Skoczen W.,Sheridan Institute of Technology and Advanced Learning
Journal of Physics: Conference Series | Year: 2010
John the Ripper (JtR) is an open source software package commonly used by system administrators to enforce password policy. JtR is designed to attack (i.e., crack) passwords encrypted in a wide variety of commonly used formats. While parallel implementations of JtR exist, there are several limitations to them. This research reports on two distinct algorithms that enhance this password cracking tool using the Message Passing Interface. The first algorithm is a novel approach that uses numerous processors to crack one password by using an innovative approach to workload distribution. In this algorithm the candidate password is distributed to all participating processors and the word list is divided based on probability so that each processor has the same likelihood of cracking the password while eliminating overlapping operations. The second algorithm developed in this research involves dividing the passwords within a password file equally amongst available processors while ensuring load-balanced and fault-tolerant behavior. This paper describes John the Ripper, the design of these two algorithms and preliminary results. Given the same amount of time, the original JtR can crack 29 passwords, whereas our algorithms 1 and 2 can crack an additional 35 and 45 passwords respectively. © 2010 IOP Publishing Ltd.
Ganapathyraju S.,Sheridan Institute of Technology and Advanced Learning
Proceedings of 2013 3rd International Conference on Instrumentation, Control and Automation, ICA 2013 | Year: 2013
This paper presents a method for hand gesture recognition to control a 6 axis industrial robot. The image is acquired by means of a web cam system, and undergoes several processing stages before a meaningful recognition can be achieved. Some of these stages include skin detection to effectively capture only the skin region of the hand, noise elimination, application of the convex hull algorithm to get the outline of the hand, and apply convexity hull defects algorithm to determine the finger count. Once the finger count has been determined, the information is transmitted via serial communication to the industrial robot controller. The end effector of the robot moves in four different directions based on the finger count input received from the hand gesture recognition module. © 2013 IEEE.
Stone M.R.,University of Toronto |
Faulkner G.E.J.,University of Toronto |
Zeglen-Hunt L.,University of Toronto |
Bonne J.C.,Sheridan Institute of Technology and Advanced Learning
Canadian Journal of Public Health | Year: 2012
Objective: In 2005, the Ontario Ministry of Education announced a policy requiring that all elementary students be provided with opportunities to participate in a minimum of 20 minutes of sustained moderate-to-vigorous physical activity (MVPA) each school day during instructional time. To the authors' knowledge, this policy has never been formally evaluated. In a form of natural experiment with Project BEAT, we explored within 16 Toronto District School Board schools the proportion of children who participate in DPA, and the proportion who achieve sustained MVPA within these sessions; these are the objectives of this article. Methods: Consent was given by 1,027 parents/guardians for their children to participate (boys, n=478; girls, n=549). Physical activity (PA) was measured using accelerometry and classroom schedules collected to identify sessions of DPA. The frequency of DPA and number and duration of sustained bouts of MVPA (≥5 min) were computed and explored relative to PA levels and health outcomes. Results: Fewer than half of the participating children were provided with DPA every day and not a single child engaged in sustained MVPA for≥20 minutes. On the more positive side, children who engaged in DPA every day were significantly more active than their peers. Those accumulating at least 1 bout of MVPA were more active and likely to meet PA guidelines, and fewer of these children were overweight. Conclusion: The majority of schools are not meeting the DPA policy. However, as the frequency and intensity of DPA increases, so do positive health outcomes. This paper provides supporting evidence that when this policy is implemented, the intended health benefits are achievable. © Canadian Public Health Association, 2012. All rights reserved.
Abdulla D.,Sheridan Institute of Technology and Advanced Learning
Computers and Education | Year: 2012
Colleges offering 2-year diplomas to high-school graduates were among the forefront leaders in online learning however studies illustrating appropriate course construction for such student populations are scarce. Pharmacy Math (MATH16532) is a core course for students enrolled in the Practical Nursing (PN) and Pharmacy Technician (PT) programs at Sheridan Institute. PT and PN students enrolled in MATH16532 during their first term were surveyed to determine student attitudes and skills gained from participating in an online course. Students were then followed up during their second term studies to determine transferability of skills gained. Initially, students did not exhibit a positive attitude towards the online version of Math16532. Participation in the online version of MATH16532 however allowed students to enhance their written ability and critical appraisal skills, gain time management skills, and become independent learners. PT and PN students preferred an orientation session at the beginning of the course and a well organized, easy-to-navigate course. Even though considered as predominantly digital native students, both student groups remained anxious throughout the course regarding the online delivery and preferred a hybrid mode of delivery. Despite the initial resistance to an online math course, students indicated that they would retake the course again in an online format towards the end of the course and there appeared to be a trend to enrol in another online course. Several recommendations regarding the design and construct of online courses in a 2-year college program are provided to facilitate acceptance of online learning for students enrolled in such programs. © 2012 Elsevier Ltd. All rights reserved.
Rayegani F.,Sheridan Institute of Technology and Advanced Learning |
Onwubolu G.C.,Sheridan Institute of Technology and Advanced Learning
International Journal of Advanced Manufacturing Technology | Year: 2014
This paper presents the research done to determine the functional relationship between process parameters and tensile strength for the fused deposition modelling (FDM) process using the group method for data modelling for prediction purposes. An initial test was carried out to determine whether part orientation and raster angle variations affect the tensile strength. It was found that both process parameters affect tensile strength response. Further experimentations were carried out in which the process parameters considered were part orientation, raster angle, raster width and air gap. The process parameters and the experimental results were submitted to the group method of data handling (GMDH), resulting in predicted output, in which the predicted output values were found to correlate very closely with the measured values. Using differential evolution (DE), optimal process parameters have been found to achieve good strength simultaneously for the response. The mathematical model of the response of the tensile strength with respect to the process parameters comprising part orientation, raster angle, raster width and air gap has been developed based on GMDH, and it has been found that the functionality of the additive manufacturing part produced is improved by optimizing the process parameters. The results obtained are very promising, and hence, the approach presented in this paper has practical application for the design and manufacture of parts using additive manufacturing technologies. © Springer-Verlag London 2014.