Sheri Kashmir Institute of Medical science

Srinagar, India

Sheri Kashmir Institute of Medical science

Srinagar, India
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Malla R.R.,Sheri Kashmir Institute of Medical science
Journal of Perinatology | Year: 2017

Objective:Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies. The efficacy and safety of EPO monotherapy in term neonates with hypoxic ischemic encephalopathy (HIE) is uncertain.Study Design:Hundred term neonates with moderate or severe HIE were randomized by random permuted block algorithm to receive either EPO 500 U kg-1 per dose in 2 ml saline intravenously (50 neonates) on alternate days for a total of five doses with the first dose given by 6 h of age (treatment group) or 2 ml of normal saline (50 neonates) similarly for a total of five doses (placebo group) in a double-blind study. No hypothermia was given. The primary outcome was combined end point of death or moderate or severe disability at mean age of 19 months (s.d., 0.61).Results:Death or moderate or severe disability occurred in 40% of neonates in the treatment group vs 70% in the placebo group (risk ratio, 0.57; 95% confidence interval (CI) 0.38 to 0.85; P=0.003). Death occurred in 16% of patients in both the groups (risk ratio, 1.0; 95% CI 0.33 to 2.9; P=0.61). The risk of cerebral palsy was lower among survivors in the treatment group (risk ratio, 0.52; 95% CI 0.25 to 1.03; P=0.04) and lesser number of babies were on anticonvulsants at assessment (risk ratio, 0.47; 95% CI 0.20 to 1.01; P=0.03). Neonatal brain magnetic resonance imaging showed more abnormalities in the placebo group (relative risk, 0.66; 95% CI 0.42 to 1.03; P=0.04)). Improvement in other neurological outcomes was not significant.Conclusion:EPO monotherapy reduces the risk of death or disability in term neonates with moderate or severe encephalopathy.Journal of Perinatology advance online publication, 9 March 2017; doi:10.1038/jp.2017.17. © 2017 Nature America, Inc., part of Springer Nature.

Riyaz M.S.U.,Sheri Kashmir Institute of Medical science | Rather M.K.,Sheri Kashmir Institute of Medical science | Koul P.A.,Sheri Kashmir Institute of Medical science
Journal of Immigrant and Minority Health | Year: 2017

Tibetan Muslims have migrated from Lhasa (3000 m altitude) to Srinagar, India (altitude 1500 m) about 55 years back. We set out to study the prevalence of diabetes and prediabetes among this immigrant population. All consenting adults aged ≥18 years were questioned about a previous history of diabetes or any other medical history. Anthropometric data were recorded. Fasting blood glucose was measured in duplicate by Accu-check glucometer and HbA1C levels were measured. Of the 281 participants, 26 (9.25%) had diabetes whereas 46 (16.4%) had pre-diabetes; 24 reporting doctor-diagnosed diabetes. Participants with diabetes/pre-diabetes were more likely to be obese, smokers and hypertensive. Multiple logistic regression analysis revealed age to be significantly associated with a higher prevalence of diabetes. One in four adults ≥18 years among Tibetan Muslims have diabetes or prediabetes. Migration to lower altitude could have contributed to this high prevalence. © 2017 Springer Science+Business Media New York

Koul P.A.,Sheri Kashmir Institute of Medical science | Broor S.,All India Institute of Medical Sciences | Saha S.,Centers for Disease Control and Prevention | Barnes J.,Centers for Disease Control and Prevention | And 4 more authors.
Emerging Infectious Diseases | Year: 2014

The seasonality of influenza in the tropics complicates vaccination timing. We investigated influenza seasonality in northern India and found influenza positivity peaked in Srinagar (34.09°N) in January–March but peaked in New Delhi (28.66°N) in July–September. Srinagar should consider influenza vaccination in October–November, but New Delhi should vaccinate in May–June. © 2014, Emerging Infectious Diseases.All rights reserved.

Ganie M.A.,Sheri Kashmir Institute of Medical science | Marwaha R.K.,Institute of Nuclear Medicine and Allied Sciences | Aggarwal R.,Institute of Nuclear Medicine and Allied Sciences | Singh S.,Institute of Nuclear Medicine and Allied Sciences
European Journal of Endocrinology | Year: 2010

Objective: The aim was to find the prevalence of polycystic ovary syndrome (PCOS) phenotype in adolescent euthyroid girls with chronic lymphocytic thyroiditis (CLT). Design: This was a prospective case-control study as part of an ongoing community-wide thyroid survey in Indian schools. Methods: One hundred and seventy-five girls with euthyroid CLT and 46 age-matched non-CLT girls underwent clinical, biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam 2003 criteria. All subjects underwent serum sampling for LH, FSH, testosterone, DHEAS, free thyroxine, TSH, and anti-thyroid peroxidase (TPO) antibodies. Oral glucose tolerance test (OGTT) was undertaken for plasma glucose and insulin. Results: Significantly higher prevalence of PCOS was noted in girls with euthyroid CLT when compared to their control counterparts (46.8 vs 4.3%, P=0.001). The CLT girls had higher body mass index, waist circumference, and systolic blood pressure (P=0.001). Mean number of menstrual cycles/year was 8.4±3.5 vs 10.1±1.4, and mean Ferriman-Gallwey score was 11.9±3.5 vs 3.0±2.4 (P=0.001) in cases versus controls respectively. The fasting and postprandial glucose and serum cholesterol were also higher in the cases (P=0.001). Homeostasis model assessment-insulin resistance was 4.4±4.2 vs 2.3±2.7 in the cases versus controls (P=0.001). Conclusion: Higher prevalence of PCOS characteristics in euthyroid CLT girls when compared to controls suggest possible role of autoimmune phenomenon in the etiopathogenesis of PCOS. Further studies are required to understand the pathogenic link between these two disorders. © 2010 European Society of Endocrinology.

Salati S.A.,Sheri Kashmir Institute of Medical science | Rather A.,Sheri Kashmir Institute of Medical science
Libyan Journal of Medicine | Year: 2010

Introduction: Penetrating hand injuries are common and improper assessment can result in missed foreign bodies. These bodies can result in a wide range of complications. Aim: The aim of our study was to study the profile of patients reporting with missed foreign bodies in the hand. Materials and methods: All the cases treated in the Department of Surgery, Sheri Kashmir Institute of Medical Sciences (medical college), Kashmir, for missed foreign bodies in hands from June 2003 to May 2009 were studied retrospectively. Results: A total of 61 cases with missed foreign bodies of different nature were treated over the period of six years. Wooden splinters were the most common foreign bodies missed. Preoperative localization was accomplished with plain radiographs and ultrasonograms. Most of the cases were treated on outpatient basis. Conclusions: Foreign bodies should be suspected and ruled out in all cases of penetrating injuries of hands. Missed foreign bodies need to be removed after proper localization by imaging. © 2010 Sajad Ahmad Salati and Ajaz Rather.

Koul P.A.,Sheri Kashmir Institute of Medical science | Khan U.H.,Sheri Kashmir Institute of Medical science
Journal of Bronchology and Interventional Pulmonology | Year: 2011

Summary: An 18-year-old male patient, earlier diagnosed to have a right lung lesion, presented with mild, sudden onset of hemoptysis and chest discomfort. The patient's radiograph showed a consolidated area in the right upper lobe with a significant reduction in the size compared with the size 5 years earlier. Computerized tomography of the chest showed a ruptured cystic lesion in the right upper lobe. Bronchoscopy showed gelatinous, white membrane-like structures extruding from the anterior segmental bronchus of the right upper lobe bronchus. The membranes were sucked out partially, and histologic examination showed laminated membranes of a hydatid cyst. The cyst was subsequently removed surgically. Bronchoscopy can be a valuable aid in the diagnosis of a ruptured hydatid cyst of the lung. Copyright © 2011 by Lippincott Williams & Wilkins.

Ali Z.,Sheri Kashmir Institute of Medical science | Bhaskar S.B.,Vijayanagar Institute of Medical science
Indian Journal of Anaesthesia | Year: 2016

Statistical methods involved in carrying out a study include planning, designing, collecting data, analysing, drawing meaningful interpretation and reporting of the research findings. The statistical analysis gives meaning to the meaningless numbers, thereby breathing life into a lifeless data. The results and inferences are precise only if proper statistical tests are used. This article will try to acquaint the reader with the basic research tools that are utilised while conducting various studies. The article covers a brief outline of the variables, an understanding of quantitative and qualitative variables and the measures of central tendency. An idea of the sample size estimation, power analysis and the statistical errors is given. Finally, there is a summary of parametric and non-parametric tests used for data analysis. © 2016 Indian Journal of Anaesthesia.

Choh N.A.,Sheri Kashmir Institute of Medical science
Journal of Pediatric Endocrinology and Metabolism | Year: 2012

Hepatic subcapsular steatosis is a rare pattern of fatty infiltration of the liver exclusively described in diabetic patients undergoing peritoneal dialysis who had received insulin in peritoneal dialysate. We describe a first case of severe subcapsular hepatic steatosis in a young diabetic patient on high dose insulin therapy (with striking subcapsular fatty infiltration of the liver documented by CT and MRI) without any evidence of chronic renal disease and not undergoing peritoneal dialysis.

Koul P.A.,Sheri Kashmir Institute of Medical science
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2011

A 43- year- old woman on treatment for primary hypothyroidism presented with 1- day progressive weakness of all her limbs and history of similar episodes in the past. Clinical examination revealed grade 2 hyporeflexive weakness. Investigations revealed features of hypokalemia, metabolic acidosis, alkaline urine, and a fractional bicarbonate excretion of 3.5%, consistent with distal renal tubular acidosis. Antithyroid peroxidase and antithroglobulin antibodies were positive, suggesting an autoimmune basis for the pathogenesis of the functional tubular defect. Bicarbonate therapy resulted in a sustained clinical recovery.

Salati S.A.,Sheri Kashmir Institute of Medical science | Rather A.A.,Sheri Kashmir Institute of Medical science
Journal of the College of Physicians and Surgeons Pakistan | Year: 2011

Endometriosis is a relatively common disorder affecting about 15% females in the reproductive age group. It is a well-known cause of infertility but endometriosis presenting as appendicitis is rare. We present a case of a 29 years old nulliparous lady in whom appendectomy was done for appendicitis and histopathological examination of the retrieved specimen revealed endometriosis. © 2011. College of Physicians & Surgeons Pakistan.

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