Shenzhen Nanshan Peoples Hospital

Shenzhen, China

Shenzhen Nanshan Peoples Hospital

Shenzhen, China
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Chen C.,CAS Shenzhen Institutes of Advanced Technology | Liu Z.,CAS Shenzhen Institutes of Advanced Technology | Li H.,CAS Shenzhen Institutes of Advanced Technology | Zhou R.,CAS Shenzhen Institutes of Advanced Technology | And 2 more authors.
Proceedings - 2016 IEEE International Conference on Smart Cloud, SmartCloud 2016 | Year: 2016

Epilepsy refers to a set of chronic neurological syndromes characterized by transient and unexpected electrical disturbances of the brain. Scalp Electroencephalogram (EEG) is a common test that measures and records the electrical activity of the brain, and is widely used in the detection and analysis of epileptic seizures. However, it is often difficult to identify the subtle changes in the EEG waveform by visual inspection. Then, emerge in large numbers of research for biomedical engineers to develop and implement several intelligent algorithms for the identification of such subtle changes. This paper presents a EEG signal analysis and forecasting technique based on wavelet trans form and support vector machine classification method. The main procedure is a dynamic circulation. The technique first train the given datasets, obtain the value of the parameter, then automatically multi-time decompose for a new person's brain signals, predict whether the person has a characteristic wave of epilepsy, add the person's EEG data into the SVM training model if the person has epilepsy abnormal signal, combined with abnormal data before retraining and learning. The method has a very large potential uses, such as application for the initial diagnosis of patients, improving the efficiency for doctors. © 2016 IEEE.


Zou L.,Shenzhen Nanshan Peoples Hospital | Jiang J.,Shenzhen Nanshan Peoples Hospital | Zhong W.,Shenzhen Nanshan Peoples Hospital | Hou G.,Shenzhen Nanshan Peoples Hospital | And 2 more authors.
Chinese Journal of Radiology (China) | Year: 2017

Objective: To compare the diagnostic values of magnetic resonance elastography (MRE) and T1ρ imaging in staging hepatic fibrosis (HF) in a rabbit model. Methods: The institutional animal care and use committee approved all experiments. Sixty healthy rabbits were divided into HF group (n=44) and control group (n=16). Each eight rabbits in the HF group and 4 rabbits in the control group were randomly selected at the 4th, 5th, 6th week and the remaining rabbits at the 10th week after subcutaneous injection with 0.1 ml 50% CCl4 oily solution per kilogram of body respectively, to undergo liver MR scan including axial liver MRE and T1ρ imaging. The values of liver stiffness (LS) and T1ρ were measured. Masson trichrome staining of liver tissue was used. According to the Scheuer scoring system, rabbits were classified into F0 to F4 group based on the percentage of hepatic fibrosis. The difference of LS values and T1ρ values among stage F0 to F4 were compared by the one-way ANOVA analysis. The correlations between pathological staging and LS, T1ρ values were performed by the Spearman correlation analysis. ROC curve analysis was performed to compare the value of MRE with T1ρ imaging. Results: Forty three rabbits were included, there were 10, 8, 8, 8, 9 rabbits in F0, F1, F2, F3 and F4 stage, respectively. LS values were (1.051±0.155), (1.335±0.235), (1.401±0.163), (2.001±0.499) and (2.981±0.714) kPa in F0, F1, F2, F3 and F4, respectively, while T1ρ values were (23.20±4.02), (24.28±2.93), (25.40±1.82), (24.69±1.85) and (31.54±3.39) ms (all P<0.05). The correlation of LS values with hepatic fibrosis staging measured on MRE was stronger than T1ρ values (r values were 0.916 and 0.608, all P<0.01). Area under ROC curve of LS value for differentiating hepatic fibrosis stage were 0.938 to 0.989, while the areas of T1ρ were 0.771 to 0.954. Conclusion: MR elastography is an accurate technique for quantitatively staging hepatic fibrosis and superior to T1ρ imaging. Copyright © 2017 by the Chinese Medical Association.


Wei Y.,Shenzhen Shekou Peoples Hospital | Wei Y.,Haikou Peoples Hospital | Xiang Y.,Shenzhen Nanshan Peoples Hospital | Sheng X.,Haikou Peoples Hospital
International Eye Science | Year: 2012

AIM: To investigate the prevalence of visual impairment, severe visual impairment and blindness, leading cause of these impairments among adults aged ≥50 years in Haikou outskirts of Hainan. METHODS: Random sampling analysis was performed in 850 individuals chosen as the sample, aged ≥50 years in 30 villages of Sanya. Corrected vision, external eye, anterior chamber, lens, vitreous, fundus were examined by ophthalmologists. The prevalence of visual impairmen, severe visual impairment and blindness was calculated, and the main cause was analyzed. RESULTS: Totally 786 individuals among 850 were examined. The response rate was 92.47%, the prevalence of visualimpairmen, severe visual impairment and blindness is 2.67%, 0.64% and 2.54%, resulting chiefly from cataract, posterior segment ocular disease and corneal scar. CONCLUSION: The epidemiological results show that the main cause of visualimpairmen, severe visual impairment and blindness is cataract. But the other causes of blindness such as posterior segment ocular disease and corneal scar can not be neglected. Copyright 2012 by IJO Press.


PubMed | General Hospital of the Yangtze River Shipping, Shenzhen Nanshan Peoples Hospital, Huizhou Municipal Central Hospital, Hospital of the Peoples Liberation Army and Huazhong University of Science and Technology
Type: | Journal: Journal of cutaneous pathology | Year: 2016

Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign fibrohistiocytic and vascular proliferation, which usually occurs as slow-growing grouped reddish-brown to purple papules and nodules on the distal extremities or face. Patients with generalized MCAH are extremely rare and to our knowledge, there are no more than 11 cases reported previously in the medical literature.To describe the clinical, histopathologic features and immunohistochemical characteristics of all reported cases of generalized MCAH and investigate any potential clinicopathological correlations.A systematic review of the literature was done with information collected and organized in a table. A new case report is also described in a 42-year-old female with generalized MCAH. Histopathologic and immunohistochemical features of multiple biopsies were analyzed.Men and women are equally affected. It is crucial to take multiple biopsies preferably from newly formed lesions to reach the correct diagnosis. The divergent results in immunohistochemistry staining for CD68 and estrogen receptor (ER) alpha necessitate further studies to reach a precise etiology and pathogenesis and secure it with certainty.Awareness of the clinicopathological hallmarks is important to avoid underdiagnosis of MCAH and the immunohistochemical features may contribute to understanding the pathogenesis of this rare disease.


Qin Y.-Y.,Guangzhou University | Li R.-F.,ShenZhen Nanshan Peoples Hospital | Wu G.-F.,Guangzhou University | Zhu Z.,Guangzhou University | And 9 more authors.
Pulmonary Pharmacology and Therapeutics | Year: 2015

Background: Studies have shown that tiotropium once daily reduces lung hyperinflation and dyspnea during exercise and improves exercise tolerance in patients with COPD. Mechanisms underlying the effects of the muscarinic receptor antagonist tiotropium on COPD have not been fully understood. Objective: In this study, we investigated whether improvement in neural respiratory drive is responsible for reducing dyspnea during exercise and improving exercise tolerance in COPD. Methods: Twenty subjects with severe COPD were randomized into two groups: no treatment (Control, n=10, 63.6±4.6 years, FEV1 29.6±13.3%pred) or inhaled tiotropium 18μg once daily for 1 month (n=10, 66.5±5.4 years, FEV1 33.0±11.1%pred). All subjects were allowed to continue their daily medications other than anti-cholinergics during the study. Constant cycle exercise with 75% of maximal workload and spirometry were performed before and 1 month after treatment. Diaphragmatic EMG (EMGdi) and respiratory pressures were recorded with multifunctional esophageal catheter. Efficiency of neural respiratory drive, defined as the ratio of minute ventilation (VE) and diaphragmatic EMG (VE/EMGdi%max), was calculated. Modified British Medical Research Council Dyspnea Scale (mMRC) was used for the evaluation of dyspnea before and after treatment. Results: There was no significant difference in spirometry before and after treatment in both groups. Diaphragmatic EMG decreased significantly at rest (28.1±10.9% vs. 22.6±10.7%, P<0.05) and mean efficiency of neural respiratory drive at the later stage of exercise increased (39.8±2.9 vs. 45.2±3.9, P<0.01) after 1-month treatment with tiotropium. There were no remarkable changes in resting EMGdi and mean efficiency of neural respiratory drive post-treatment in control group. The score of mMRC decreased significantly (2.5±0.5 vs. 1.9±0.7, P<0.05) after 1-month treatment with tiotropium, but without significantly difference in control group. Conclusion: Tiotropium significantly reduces neural respiratory drive at rest and improves the efficiency of neural respiratory drive during exercise, which might account for the improvement in exercise tolerance in COPD. © 2014.


PubMed | Chinese University of Hong Kong, Shenzhen University and Shenzhen Nanshan Peoples Hospital
Type: Journal Article | Journal: The International journal of neuroscience | Year: 2015

To study the characteristics of hospitalized pain patients in Shenzhen with the aim of identifying some of the social, economic and therapeutic aspects of pain management in China.A retrospective study was designed to collect the information of 3061 hospitalized pain patients in 2003, 2007 and 2011. Their demographic characteristics, diagnoses of pain types, hospitalization, therapeutic effect, economic cost and payment types were analyzed.The number of female patients significantly increased with time. The patients average age increased from 41.3 in 2003 to 49.7 years old in 2011. The most common diagnosis of pain was lumbar intervertebral disc herniation. The total hospitalization days of each patient per year significantly decreased from 15.7 days in 2003 to 10.4 days in 2011. However, the hospitalization cost for each patient was almost doubled.The hospitalized pain patients and their economic burdens have almost been doubled in the recent four years.


PubMed | Chinese University of Hong Kong, Shenzhen University and Shenzhen Nanshan Peoples Hospital
Type: Journal Article | Journal: The International journal of neuroscience | Year: 2016

To study the characteristics of hospitalized pain patients in Shenzhen with the aim of identifying some of the social, economic and therapeutic aspects of pain management in China.A retrospective study was designed to collect the information of 3061 hospitalized pain patients in 2003, 2007 and 2011. Their demographic characteristics, diagnoses of pain types, hospitalization, therapeutic effect, economic cost and payment types were analyzed.The number of female patients significantly increased with time. The patients average age increased from 41.3 in 2003 to 49.7 years old in 2011. The most common diagnosis of pain was lumbar intervertebral disc herniation. The total hospitalization days of each patient per year significantly decreased from 15.7 days in 2003 to 10.4 days in 2011. However, the hospitalization cost for each patient was almost doubled.The hospitalized pain patients and their economic burdens have almost been doubled in the recent four years.


Wang M.,Shenzhen Nanshan Peoples Hospital | Qu T.,Shenzhen Nanshan Peoples Hospital | Fang K.,Shenzhen Nanshan Peoples Hospital
Journal of Clinical Dermatology | Year: 2016

A case of ectopic extramammary Paget's disease (E-EMPD) is reported. A two-year history of asymptomatic erythematous lesion on her right infraclavicular region. Hi: That pagetoid cells diffusely or foeally distributed in the epidermis. Immunohistochemica! staining showed that the tumor cells were positive for carcinocmbryonic antigen(CEA) and cytokeratin 7(CK7), and negative for S-100 protein and cytokeratin 20 (CK20). Histopathological findings were consistent with E-EMPD. The patient did not have any evidence of recurrence during two-year follow-up after surgical excision.


Peng K.-W.,ShenZhen Nanshan Peoples Hospital | Lei Z.,Shenzhen NanShan Peoples Hospital | Xiao T.-H.,Shenzhen NanShan Peoples Hospital | Jia F.-G.,ShenZhen Nanshan Peoples Hospital | And 4 more authors.
Clinical Radiology | Year: 2014

AIM: To determine the features of caesarean scar ectopic pregnancy (CSP) by using magnetic resonance imaging (MRI) in the first trimester. MATERIALS AND METHODS: Thirty-nine women with CSP in the first trimester were initially selected and underwent transvaginal ultrasound and MRI examinations. Thirty-five patients with CSP were finally included in this study. RESULTS: The CSPs were categorized into three groups: type I, in which a thin-walled diverticulum is present at the caesarean section scar (CSS) defect and the gestational sac (GS) is embedded in the diverticulum; type II, in which a thin-walled diverticulum is present at the CSS defect and the GS is partially embedded in the diverticulum; type III, in which a niche is present in the CSS defect and the GS is mainly embedded in the isthmus. Types I, II, and III CSP occurred in 40, 46, and 14% of the women, respectively. There was no significant difference between the three types in the minimum thickness of the CSS defect. In types I and II, there was a positive correlation in the maximum inlet diameter of the CSS defect and the approximate area of the GS. CONCLUSION: Using MRI, most CSPs present as a diverticulum at the CSS defect, and the CSS defect becomes weaker with the growth of the GS. MRI showed detailed features of the CSP. © 2013 The Royal College of Radiologists.


PubMed | Shenzhen NanShan Peoples Hospital
Type: Journal Article | Journal: Clinical radiology | Year: 2014

To determine the features of caesarean scar ectopic pregnancy (CSP) by using magnetic resonance imaging (MRI) in the first trimester.Thirty-nine women with CSP in the first trimester were initially selected and underwent transvaginal ultrasound and MRI examinations. Thirty-five patients with CSP were finally included in this study.The CSPs were categorized into three groups: type I, in which a thin-walled diverticulum is present at the caesarean section scar (CSS) defect and the gestational sac (GS) is embedded in the diverticulum; type II, in which a thin-walled diverticulum is present at the CSS defect and the GS is partially embedded in the diverticulum; type III, in which a niche is present in the CSS defect and the GS is mainly embedded in the isthmus. Types I, II, and III CSP occurred in 40, 46, and 14% of the women, respectively. There was no significant difference between the three types in the minimum thickness of the CSS defect. In types I and II, there was a positive correlation in the maximum inlet diameter of the CSS defect and the approximate area of the GS.Using MRI, most CSPs present as a diverticulum at the CSS defect, and the CSS defect becomes weaker with the growth of the GS. MRI showed detailed features of the CSP.

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