Shenzhen Mental Health Center

Shenzhen, China

Shenzhen Mental Health Center

Shenzhen, China
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Liu T.,Jinan University | Liu T.,Guangzhou University | Wang Y.,Jinan University | Zhong S.,Jinan University | And 4 more authors.
Journal of Affective Disorders | Year: 2017

Background Recent many studies found the abnormal neurometabolites in the acute bipolar disorder (BD). However, limited studies were to detect neurometabolites in remitted BD, comparison between acute and remitted BD is conductive to understand the outcome of neurometabolites. This study sought to investigate the differences in neurometabolites between remitted and depressed BD patients using proton magnetic resonance spectroscopy (1H-MRS). Methods Three subject groups were enrolled: 22 remitted BD patients, 22 depressed BD patients and 24 healthy controls. All subjects underwent 1H-MRS to measure N-acetylaspartate (NAA), Choline (Cho), myo-Inositol (mI) and Creatine (Cr) of several bilateral areas potentially involved in BD: prefrontal whiter matter (PWM), thalamus and putamen. The neurometabolite ratios were compared among three groups. The correlations between abnormal neurometabolite ratios and clinical data were computed. Results The lower bilateral PWM NAA/Cr ratios were found in depressed BD patients than remitted BD patients and healthy controls, no differences were found between the remitted BD patients and controls. For depressed BD patients, left PWM NAA/Cr ratios showed negative correlation with age of onset, right PWM NAA/Cr ratios showed positive correlation with duration of illness. Conclusions Our findings suggest the abnormal neurometabolites in the prefrontal lobe whiter may occur in the depressed BD. The remitted BD may resemble healthy subjects in terms of neurometabolites. In addition, abnormal neurometabolites in prefrontal lobe whiter may correlate with the age of onset and illness length. © 2017 Elsevier B.V.


PubMed | University of Melbourne, Shanghai JiaoTong University, Chinese Institute of Clinical Medical Sciences, Zhejiang University and 7 more.
Type: | Journal: Psychiatry research | Year: 2016

Little is known about the demographic and clinical differences between early-onset (EOB) and late-onset bipolar disorders (LOB) in Chinese patients. This multi-center study examined the demographic and clinical characteristics of EOB (21 years) and LOB (>21 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) from 7 psychiatric hospitals and general hospital psychiatric units across China was examined. Patients demographic and clinical characteristics were collected using a standardized protocol and data collection procedure. There were 181 (34.8%) patients with EOB and 339 (65.2%) with LOB. Univariate analyses revealed that compared to the LOB group, the EOB group were more likely to be older, unemployed, have a longer illness duration, have BD-I and misdiagnosed as schizophrenia but were less likely to be misdiagnosed as major depressive disorder and receiving antidepressants. Multivariate analyses revealed that unemployment and longer duration of illness were independently associated with EOB. The clinical differences between early-onset and late-onset BD patients in China were largely consistent with those found in Western countries. Early-onset BD appear to be associated with poorer outcomes. Prospective studies examining the long-term outcomes in relation to age-at-onset are needed.


PubMed | Tongji University, Shanghai JiaoTong University, Nanjing Medical University, Central South University and 9 more.
Type: Journal Article | Journal: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology | Year: 2015

To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD).This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively.Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=-4.39, p<0.001), were older (t=-4.69, p0.001), reported more lifetime depressive episodes (z=-3.24, p=0.001), were more likely to experience seasonal depressive episodes ((2)=6.896, p=0.009) and depressive episodes following stressful life events (2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders ((2)=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression.These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.


Yang H.-C.,Central South University | Yang H.-C.,Shenzhen Mental Health Center | Yuan C.-M,Shanghai JiaoTong University | Liu T.-B.,Shenzhen Mental Health Center | And 6 more authors.
BMC Psychiatry | Year: 2011

Background: The 32-item Hypomania Checklist (HCL-32), a questionnaire for screening bipolar disorders, has been utilised in several countries, but it unclear if the Chinese version of the HCL-32 is valid.Methods: Consecutive patients with bipolar disorders (BP, N = 300) and unipolar major depression (UP, N = 156) completed the Chinese version of the HCL-32. The subjects underwent a structured clinical interview for DSM-IV Axis-I disorders (SCID).Results: The eigenvalues for the first three factors in the HCL-32 were calculated as 5.16 (active/elated), 2.72 (risk-taking) and 2.48 (irritable) using factor analysis. Cronbach's alpha for the HCL-32 was calculated to be 0.88. Positive responses to twenty-eight items were significantly more frequent by patients with BP than those with UP, and the other four items (7th, 21st, 25th and 32nd) showed no such trend. Fourteen was the optimal cut-off for discriminating between BP and UP. The HCL-32 distinguished between BP-II and UP, with 13 being the optimal cut-off. A cut-off of 13 yielded a sensitivity of 0.77 and a specificity of 0.62 between BP and UP.Conclusions: This study demonstrated that the simplified Chinese version of HCL-32 was valid for patients with mood disorders. The optimal cut-off of 13 for distinguishing between BP-II and UP was valid and could be used to improve the sensitivity of screening BP-II patients when the HCL-32 is used in psychiatric settings in China. © 2011 Yang et al; licensee BioMed Central Ltd.


PubMed | Guangzhou Medical College, University of Zürich, Central South University, CAS Shenzhen Institutes of Advanced Technology and 2 more.
Type: | Journal: Journal of affective disorders | Year: 2016

Bipolar disorder (BD) is difficult to diagnose in the early stages of the illness, with the most frequent misdiagnosis being major depressive disorder (MDD). We aimed to use a regional homogeneity (ReHo) approach with resting-state functional magnetic resonance imaging (rs-fMRI) to investigate the features of spontaneous brain activity in MDD patients screening positive on the 32-item Hypomania Checklist (HCL-32).Nineteen MDD patients screening positive (HCL-32(+); 9 males; 24.95.7 years) and 18 patients screening negative (HCL-32(-); 9 males; 27.16.7 years), together with 24 healthy controls (HC; 11 males; 26.43.9 years) were studied. ReHo maps were compared and an receiver operating characteristic (ROC) analysis was conducted to confirm the utility of the identified ReHo differences in classifying the patients.The MDD versus HC showed different ReHo in many brain areas, especially in the frontal and parietal cortex. The HCL-32(+) versus HCL-32(-) showed significant increase of ReHo in the right medial superior frontal cortex, left inferior parietal cortex and middle/inferior temporal cortex, and decrease of ReHo in the left postcentral cortex and cerebellum. ROC analysis showed good sensitivity and specificity for distinguishing these two subgroups of MDD.Recruited patients were all on antidepressants and standard mania rating scales were not performed to assess their hypomanic symptoms.The rs-fMRI measurement of ReHo in distributed brain regions may be putative biomarkers which could differentiate subthreshold BD from MDD.


Hu H.-M.,China Pharmaceutical University | Hu H.-M.,Sun Yat Sen University | Zhang X.,Sun Yat Sen University | Zhang X.,Shenzhen Mental Health Center | And 2 more authors.
Journal of Biomaterials Science, Polymer Edition | Year: 2012

A non-viral gene-delivery system has been used to deliver plasmid DNA into specific cell types because of its safety and ease of manufacture. Receptor-mediated gene transfer is currently a promising gene-delivery technique. To specifically target genes to asialoglycoprotein receptor of hepatocytes, a galactose moiety was combined into the poly(ethylene glycol) (PEG)-terminal end by reductive coupling using lactose and sodium cyanoborohydride. A synthesis method of conjugating poly(L-lysine) (PLL) derivatives with terminally galactose-graft-PEG was developed using ring-opening polymerization of N ε -benzyloxycarbonyl-L-lysine-N α -carboxyan-hydride (Z-Lys-NCA) initiated onto galactose graft amine-terminated PEG (galactose-PEG-NH 2) as a macro-initiator. The synthesis was characterized with 1H-, 13C-NMR, IR and UV spectroscopy, and all of them successfully verified the formation of the co-polymers. The gel-retardation assay of the complexes between galactose-PEG-PLL and plasmid DNA indicated that these polymeric gene carriers demonstrated the potent ability to condense plasmid DNA electrostatically as well as PLL. The particle size and zeta potential of polymer/DNA complexes were measured, and their cytotoxicity and transfection efficiency in different cells were evaluated. The results indicate that galactose-PEG-PLL can form a complex with plasmid DNA and serve as an effective gene-delivery carrier with lower cytotoxicity compared to that of PLL. Transfection experiments clearly showed that galactose-PEG-PLL effectively delivered DNA into hepatoma cells in vitro. Such data demonstrates that galactose and its complex with plasmid DNA may serve as a safe and effective gene-transfer system targeting hepatocytes. © 2012 VSP.


Ke X.,Guangzhou University | Ke X.,Shenzhen Mental Health Center | Ding Y.,Guangzhou University | Xu K.,Yale University | And 9 more authors.
Drug and Alcohol Dependence | Year: 2014

Aims: This study investigated the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in a group of chronic ketamine abusers in comparison to healthy controls. The correlations between the serum BDNF, NGF level with the subjects' demographic, pattern of ketamine use were also examined. Methods: 93 subjects who met the criteria of ketamine dependence and 39 healthy subjects were recruited. Serum BDNF and NGF levels were assayed by enzyme-linked immunosorbent assay (ELISA). Psychopathological symptoms were assessed using Positive and Negative Syndrome Scale (PANSS), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Results: Both serum levels of BDNF and NGF were significant lower in the ketamine users compared to the healthy control subjects (9.50. ±. 6.68 versus 14.37. ±. 6.07. ng/ml, p= 0.019 for BDNF; 1.93. ±. 0.80 versus 2.60. ±. 1.07. ng/ml, p= 0.011 for NGF). BDNF level was negatively associated with current frequency of ketamine use (r= -0.209, p= 0.045). Conclusions: Both BDNF and NGF serum concentrations were significantly lower among chronic ketamine users than among health controls. © 2014 Elsevier Ireland Ltd.


Wei Z.,Shenzhen Mental Health Center | Wei Z.,Chinese University of Hong Kong | Hu C.,Shenzhen Mental Health Center | Wei X.,Shenzhen Mental Health Center | And 3 more authors.
Psychiatric Services | Year: 2013

Objective: The purpose of this study was to investigate the prevalence and predictors of service utilization for mental health problems of the first-generation migrant population in Shenzhen, China, a city that attracts millions of unskilled rural laborers each year. Methods: Using the structured World Mental Health Composite International Diagnostic Interview, the investigators conducted face-to-face surveys between September 1, 2005, and January 30, 2006. A total of 7,134 respondents age 18 years and above finished the surveys. The main outcomes were prevalence of mental disorders according to DSM-IV criteria, as well as prevalence of mental health services used in different sectors. Results: Nine percent of the sample had ever used some type of service for mental health issues, and 6.3% used services outside of the health service sector, such as human services and complementary and alternative medicine. In addition, DSM criteria for a mental disorder over the lifetime were met by 18.1% of respondents; of the respondents with a mental disorder, 18.3% had used mental health services at least once. Migrants who were unmarried, had high family income, were raised in metropolitan areas, had histories of homelessness or attempted suicide, had a psychotic disorder, or had an anxiety disorder were more likely to use services for mental health care. Conclusions: In Shenzhen, few migrants used mental health services and most used complementary and alternative medicine services. Future studies of service utilization patterns in migrant populations should give special attention to personal characteristics, such as family support.


Chen S.,Shenzhen University | Guo Y.,Shenzhen University | Yu H.,Shenzhen University | Ge Z.,Shenzhen University | And 3 more authors.
Journal of Materials Chemistry | Year: 2012

Due to the outbreaks of infectious diseases caused by different pathogenic bacteria and development of antibiotic resistance, researchers are actively searching for new antibacterial agents. Synergistic antibacterial effects provide a new way to prepare antibacterial systems to fight resistant bacteria. In this study, novel copper (Cu)/titanium dioxide (TiO 2)/chitosan (CS) (CTC) three-component nanoparticles were facilely prepared via photocatalytic reduction on the basis of the synergistic antibacterial principle. The structure, antibacterial activity and antibacterial mechanism of CTC were investigated systematically. The results showed that this hybrid material exhibits excellent antibacterial ability against Escherichia coli and Staphylococcus aureus due to the synergistic antibacterial effect of the Cu, TiO 2 and CS components in the nanoparticles. The minimal inhibition concentrations (MIC) of CTC against E. coli and S. aureus are only 5.22 μg mL -1 and 2.61 μg mL -1, respectively, much lower than the two-component systems. Thus, the encouraging results presented in this study demonstrate great potential applications of CTC as an alternative candidate for an antibacterial agent with high antibacterial activity. © 2012 The Royal Society of Chemistry.


PubMed | CAS Shenzhen Institutes of Advanced Technology, Shenzhen Mental Health Center and China Pharmaceutical University
Type: Comparative Study | Journal: International journal of pharmaceutics | Year: 2014

A new series of multi-armed MP-g-PPI dendrimers were synthesized by polymerization of BLG-NCA using G2.0PPI as macromolecular initiator and subsequent aminolysis with G1.0PPI or G2.0PPI. The chemical structure and composition of the MP-g-PPI dendrimers were characterized by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy ((1)H NMR). The MP-g-PPI showed a great ability to combine with pDNA to form complexes, which protect the pDNA from nuclease degradation. Dynamic light scattering (DLS) measurement illustrated that the sizes of complexes were in range of 111-219 nm. The transmission electron microscope (TEM) and atomic force microscope (AFM) observation showed that the morphology of these complexes was spherical. The MTT assay demonstrated that cytotoxicity of the MP-g-PPI was lower than that of PEI 25K. The in vitro transfection test indicated that MP-g-PPI gene vectors displayed relative high transfection efficiency than that of PEI 25K and Lipofectamine 2000 in serum-containing medium. Furthermore, MP-g-PPI at the weight ratio of 7.5 displayed better serum-resistant capability than that of PEI 25K and Lipofectamine 2000. The above facts revealed that multi-armed MP-g-PPI dendrimers may be promising gene vectors with low cytotoxicity, high transfection efficiency and serum-resistant ability.

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