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Liang Z.,Guangzhou University | Ren L.,Guangzhou University | Wang T.,Guangzhou University | Hu H.,Shenzhen Second Peoples Hospital | And 4 more authors.
Australasian Physical and Engineering Sciences in Medicine | Year: 2016

The efficacy of thrombolytic therapy for acute ischemic stroke (AIS) decreases when the administration of tissue plasminogen activator (tPA) is delayed. Derived from Toyota Production System, lean production aims to create top-quality products with high-efficiency procedures, a concept that easily applies to emergency medicine. In this study, we aimed to determine whether applying lean principles to flow optimization could hasten the initiation of thrombolysis. A multidisciplinary team (Stroke Team) was organized to implement an ongoing, continuous loop of lean production that contained the following steps: decomposition, recognition, intervention, reengineering and assessment. The door-to-needle time (DNT) and the percentage of patients with DNT ≤ 60 min before and after the adoption of lean principles were used to evaluate the efficiency of our flow optimization. Thirteen patients with AIS in the pre-lean period and 43 patients with AIS in the lean period (23 in lean period I and 20 patients in lean period II) were consecutively enrolled in our study. After flow optimization, we reduced DNT from 90 to 47 min (p < 0.001¤). In addition, the percentage of patients treated ≤60 min after hospital arrival increased from 38.46 to 75.0 % (p = 0.015¤). Adjusted analysis of covariance confirmed a significant influence of optimization on delay of tPA administration (p < 0.001). The patients were more likely to have a good prognosis (mRS ≤ 2 at 90 days) after the flow optimization (30.77–75.00 %, p = 0.012¤). Our study may offer an effective approach for optimizing the thrombolytic flow in the management of AIS. © 2016 Australasian College of Physical Scientists and Engineers in Medicine Source

Liang J.,Xian Jiaotong University | Tan H.,Shenzhen Key Laboratory of Neurosurgery | Xiao C.,Xian Jiaotong University | Zhou G.,Xian Jiaotong University | And 2 more authors.
Journal of Power Sources | Year: 2015

Despite the great progress in NiO-based materials for supercapacitors in recent years, the tested specific capacitance of NiO-based materials is usually much lower than its theoretical specific capacitance. Here, a novel hierarchical nickel oxide@halloysite nanocomposite has been synthesized via a simple precipitation reaction. In the resulting structure, halloysite tubes with abundant hydroxyl group are closely assembled with ultrathin and standing NiO nanoflakes. This architecture designed is expected to enrich accessible electroactive sites, faster kinetics of NiO/NiOOH redox pair, as well as enhance participation degree of NiO during the charging/discharging process. As a result, the as-prepared NiO@halloysite nanocomposite exhibits excellent electrochemical properties in terms of high charge storage capacitance (1047.3 F g-1 at 5 A g-1), high rate capability and stable cycling performance (1338 F g-1 after 7200 cycles at a current of 10 A g-1). © 2015 Published by Elsevier B.V. Source

Tan H.,Sun Yat Sen University | Tan H.,Shenzhen Key Laboratory of Neurosurgery | Zhao L.,Ningbo University | Liu W.,University of New Mexico | And 4 more authors.
RSC Advances | Year: 2014

A novel alternative was developed for the synthesis of polymer-protein conjugates with a controllable number of polymer chains. Human serum albumin (HSA), as a model protein, was grafted by poly(N-isopropyl-acrylamide) (PNIPAM) using N-succinimidyl-3-(2-pyridyldithiol) propionate as a coupling agent at room temperature in aqueous media. The influence of grafting number on the stability of the protein-polymer conjugate against the degradation of enzyme was examined, and the temperature dependent bioactivity was monitored through testing the warfarin-binding affinity. Furthermore, the protein could be recovered by incubating the conjugate under reducing conditions to cause the cleavage of the multiple disulfide bonds. © The Royal Society of Chemistry 2014. Source

Li J.,Ningbo University | Hu W.,Ningbo University | Zhang Y.,Ningbo University | Tan H.,Shenzhen Key Laboratory of Neurosurgery | And 3 more authors.
Journal of Polymer Science, Part A: Polymer Chemistry | Year: 2015

Injectable hydrogels with pH and glucose triggered drug release capability were synthesized based on biocompatible phenylboronic modified chitosan and oxidized dextran through the formation of covalent imine bond and phenylboronate ester. Rheological characterization demonstrated that the gelation rate was rapid, and the moduli of the hydrogels were able to be tuned with chemical composition as well as pH and glucose concentration of the polymer solution. Anticancer drugs could be incorporated inside the hydrogel through the in situ gel forming process and undergo a controlled release by altering pH or glucose concentration. The hydrogels had good biocompatibility with viable and proliferated cells cultured in the three dimensional matrix, and the cell proliferation was suppressed when a small amount of DOX was added, which is benefit for the application of the hydrogels as smart anticancer drug delivery system.J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1235-1244 pH and glucose dually responsive injectable hydrogels are synthesized based on biocompatible phenylboronic modified chitosan and oxide dextran through the formation of a dynamic covalent imine bond and phenylboronate ester. Drugs and cells can be encapsulated inside the hydrogels through the in situ gel-forming process. Sustained and controlled drug release, and sensitive cell proliferation in the 3D hydrogel matrix are observed, showing potential applications of the system in biomedicine. © 2015 Wiley Periodicals, Inc. Source

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