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Xie Z.-G.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | Liu T.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | Guo S.-J.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | Li J.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | And 2 more authors.
Journal of Interventional Radiology (China) | Year: 2012

Objective: To observe the clinical effect of percutaneous transhepatic bile duct balloon dilation, draining and 125I seed chain implantation for the treatment of malignant biliary obstruction. Methods: Four patients with malignant biliary obstruction caused by cholangiocarcinoma (n = 1), hepatocellular carcinoma (n = 2) or carcinoma of pancreatic head (n = 1) were enrolled in this study. Preoperative levels of total bilirubin of the four patients were 230umol/L, 450 umol/L, 670 umol/L and 280 μmol/L respectively. Percutaneous transhepatic bile duct balloon dilation and draining were performed first, which was followed by 125I seed chain implantation into the involved segment of bile duct, and no bile duct stent implantation was employed. The clinical results were analyzed. Results: The procedure was successfully accomplished in all the four patients. The level of total bilirubin was reduced to almost normal range in all the four patients at 14-19 days after the treatment. The draining catheters were removed in 10-23 days after the procedure. The four patients were followed up for 6, 5, 4.5 and 4 months respectively, and no recurrence of jaundice was observed. Three patients were still alive so far. One patient with carcinoma of pancreatic head died of general asthenia at 6.5 months after operation. Conclusion: The therapy method of percutaneous transhepatic bile duct balloon dilation, draining together with 125I seed chain implantation has marked effect on the regression of jaundice in patients with malignant biliary obstruction. The bile duct patency might be effectively maintained for a longer time. Therefore, this combination interventional procedure is deserved to be further studied.


Chen B.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | Xie Z.-G.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | Mao Y.-F.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | Li J.,Shenzhen Municipal Hospital of Traditional Chinese Medicine | And 5 more authors.
Journal of Interventional Radiology (China) | Year: 2015

Objective To design a biliary drainage catheter carrying 125I seeds to be used in percutaneous transhepatic procedure for the treatment of malignant biliary obstruction as it carries dual therapeutic effect of intra-biliary radiotherapy as well as bile drainage. Methods The polyurethane material was obtained from conventional catheter. Using heating, elongation and casting techniques, a catheter with three-cavity structure was formed. The outer diameter of this catheter was 8 - 10 F and the three-cavity inner diameters were 0.75 mm, 0.75 mm and ≥ 1.0 mm respectively. The & 1.0 mm lumen was used as bile drainage channel, while the other two lumens of 0.75 mm were used to load 125I seeds. The end of the catheter was specially designed in order to facilitate the placement of 125I seeds and the connection with drainage bag. Results This self-developed biliary drainage catheter carrying 125I seeds had reasonable structure, the 125I seeds could be smoothly inserted into its lumen. Under fluoroscopic observation, the 125I seeds arranged in rows and the seeds remained stable in the position without shifting. The draining lumen of the catheter was well connected with the drainage interface, which ensured a fluent bile flow. Conclusion This self - developed biliary drainage catheter has good drainage effect, besides the 125I seeds that the catheter carries have radiotherapy effect. The radiation dose and biological effect of the line - Arranged 125I seeds need to be further determined. More animal experiments on the feasibility and safety of this procedure are needed.

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