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Lin H.,Guangdong Provincial Institute of Public Health | Lin H.,U.S. Center for Disease Control and Prevention | Zou H.,Baoan Chronic Diseases Prevent and Cure Hospital | Wang Q.,Chinese University of Hong Kong | And 5 more authors.
PLoS ONE | Year: 2013

Hand, foot and mouth disease (HFMD) was an emerging viral infectious disease in recent years in Shenzhen. The underlying risk factors have not yet been systematically examined. This study analyzed the short-term effect of El Niño-Southern Oscillation on pediatric HFMD in Shenzhen, China. Daily count of HFMD among children aged below 15 years old, Southern Oscillation Index (SOI), and weather variables were collected to construct the time series. A distributed lag non-linear model was applied to investigate the effect of daily SOI on pediatric HFMD occurrence during 2008-2010. We observed an acute effect of SOI variation on HFMD occurrence. The extremely high SOI (SOI = 45, with 0 as reference) was associated with increased HFMD, with the relative risk (RR) being 1.66 (95% Confidence Interval [CI]: 1.34-2.04). Further analyses of the association between HFMD and daily mean temperature and relative humidity supported the correlation between pediatric HFMD and SOI. Meteorological factors might be important predictors of pediatric HFMD occurrence in Shenzhen. © 2013 Lin et al. Source


Lin H.L.,Guangdong Provincial Institute of Public Health | Lin H.L.,U.S. Center for Disease Control and Prevention | An Q.Z.,Fudan University | Wang Q.Z.,Shandong University | Liu C.X.,Shenzhen Entry Exit Inspection and Quarantine Bureau
Public Health | Year: 2013

Objective: Inconsistent findings of association between supplemental folate consumption and pancreatic cancer risk have been observed in the literature. This study aims to summarize the relationship between folate intake and risk of pancreatic cancer. Study design: Pertinent studies published before November 2011 were identified by searching PubMed and Embase and by reviewing the reference lists of retrieved articles. The summary relative risks were estimated by the random effects model. A linear regression analysis of the natural logarithm of the relative risk (RR) was carried out to assess a possible dose-response relationship between folate intake and pancreatic cancer risk. Results: Ten studies on dietary and supplemental folate intake and pancreatic cancer (4 case-control and 6 cohort studies) were included in the meta-analysis. The pooled RRs of pancreatic cancer for the highest vs lowest categories of dietary folate intake and supplemental folate intake were 0.66 (95% CI: 0.49-0.88) and 1.08 (95% CI, 0.82-1.41), respectively. The dose-response meta-analysis indicated that a 100μg/day increment in dietary folate intake conferred a RR of 0.93 (95% CI: 0.90-0.97). These findings support the hypothesis that dietary folate may play a protective role in carcinogenesis of pancreatic cancer. © 2013 The Royal Society for Public Health. Source


Li W.,Tsinghua University | Song G.,Tsinghua University | Li S.,Shenzhen Entry Exit Inspection and Quarantine Bureau | Yao Y.,Tsinghua University | Tang G.,Tsinghua University
Energy | Year: 2014

MicroPCMs (microencapsulated phase-change materials) were successfully synthesized using MPS (3-(trimethoxysilyl) propyl methacrylate) and VTMS (vinyltrimethoxysilane) as raw materials for hybrid shells, and n-octadecane as core materials. DSC (differential scanning calorimeter) results show that two types of crystals form in core materials of all MicroPCMs during crystallization. The weight ratio of MPS-VTMS, and pH values play significant roles on the performance of final product: n-Octadecane content of MicroPCMs increases from 58.7wt.% to 76.0wt.% and their thermal degradation temperature (2wt.% weight loss) increases from 182.6°C to 188.9°C with the weight ratio of MPS-VTMS decreasing from 8:0 to 2:6 in neutral synthesis systems. However, the encapsulation of n-octadecane failed when only using VTMS as hybrid shell precursor; When the weight ratio of MPS-VTMS is fixed to 2:6, the encapsulation efficiency decreases in acidic or basic synthesis systems. The optimized final product, i.e., MicroPCMs obtained with the weight ratio of MPS-VTMS equaling to 2:6 in neutral conditions, display a best thermal properties with highest melting and crystallization latent heat of 166.74Jg-1 and 169.35Jg-1, and the n-octadecane content decreases only by 7.0wt.% and 10.8wt.% after thermal treatment and thermal cycling test, respectively. © 2014 Elsevier Ltd. Source


Zhang S.,Luoyang Institute of Science and Technology | Song X.,Luoyang Institute of Science and Technology | Zhang W.,Shenzhen Entry Exit Inspection and Quarantine Bureau | Luo N.,Wuhan University | Cai L.,Iowa State University
Science of the Total Environment | Year: 2013

As a sensitive biomarker, the level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) indicates the extent of DNA oxidative damage of subject. However its determination in human urine is confounded by trace content and a complex matrix. In this study, a new approach of solid phase microextraction (SPME) coupled to capillary electrophoresis and electrochemical detection was developed with molecularly imprinted monolithic column as extraction sorbent. The tailor made monolith exhibited high extraction efficiency with the enrichment factor 73 for 8-OHdG owing to its special porous structure and inherent selectivity. Under optimal conditions, appreciable sensitivity had been achieved with a limit of detection of 2.61. nmol/L (signal/noise=3) and a limit of quantification of 8.63. nmol/L (signal/noise=10), respectively. As an alternative of precise 8-OHdG determination, wide range linearity had been achieved with 0.01-1.50 μmol/L and RSDs with 3.70% for migration time and 4.80% for peak current (10-1000. nmol/L). 106 samples with relative low extents of DNA oxidative damage were collected and analyzed which including coke plant workers, traffic policemen, taxi drivers and healthy students. Elevated urinary 8-OHdG excretions of subjects may correlate to working condition, occupational exposure, or lifestyle. © 2013 Elsevier B.V. Source


Zhao L.,Ocean University of China | Fan F.,Shenzhen Entry Exit Inspection and Quarantine Bureau | Wang P.,Ocean University of China | Jiang X.,Ocean University of China
Applied Microbiology and Biotechnology | Year: 2013

A new kind of extracellular polysaccharide (EPS) from Pseudomonas fluorescens PGM37 was obtained and culture media was optimized using the statistical methods single factor experiments and response surface methodology (RSM) design. As a result, the optimum cultivation conditions initial pH value, medium volume, inoculum size, temperature, and rotation speed were 7.5, 100 mL/250 mL, 5 %, 28 °C, and 180 rpm, respectively. The optimized media: sucrose 36.23 g L-1, yeast extract 3.32 g L-1, sodium chloride 1.13 g L-1, and calcium chloride 0.20 g L-1. The maximum predicted yield of EPS was 10.1163 g L-1 under these conditions. The validation data was 10.012 g L-1, which could strongly confirm the correlation between the experimental and theoretical values. Gas Chromatography analysis revealed that the polymer was made up of mannose and glucose in the ratio of 1:1. Infrared spectroscopy showed that the polysaccharide had β-D-pyranoid configuration and contained no other substituent. Graded by different multiples of alcohol after specific degradation by enzyme and then detected by LC-ESI-MS, the EPS structure was β-D-Glcp-(1, 4)-β-D-Manp-(1, 4)-β-D-Glcp-(1, 4)-β-D-Manp. The moisture retention ability of the EPS was found to be superior to glycerol and only a little inferior to hyaluronic acid (HA), which presented potential application value in cosmetics and clinical medicine fields. © 2012 Springer-Verlag Berlin Heidelberg. Source

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