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Zhu W.,Guangzhou University | Zhu W.,Shenzhen University | Zhu W.,Shenzhen Tissue Engineering Laboratory | Zhu W.,Shenzhen Digital Orthopaedic Engineering Laboratory | And 15 more authors.
Artificial Cells, Nanomedicine and Biotechnology

Objective : To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone. Methods : From September 2009 to June 2012, 27 cases of bone defect were analyzed retrospectively. The position of bone defect included humerus, radius, ulna, femur, tibia and calcaneus. The range of bone defect was from 0.3 ± 1.0 cm to 3 ± 6.5 cm. Among them, there were 22 cases with fractures and 5 cases with tumors. All patients were treated with Nano-HA artifi cial bone. The ability of bone defect repair was evaluated by X-ray exams performed preoperatively and postoperatively. HSS scores were adopted for fi nal evaluation at the latest follow-up. Results : The patients were followed up from 11 to 26 months (average of 18.5 months). No general side eff ects occurred. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication. Conclusion : The Nano-HA artifi cial bone had a good biocompatibility and could be an ideal artifi cial bone in the reconstruction of bone defect. Copyright © 2014 Informa Healthcare USA, Inc. Source

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