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Tong Y.,U.S. Center for Disease Control and Prevention | Tong Y.,Huazhong University of Science and Technology | Tong Y.,Shenzhen Center for Disease Controls and Prevention | Zhan F.,U.S. Center for Disease Control and Prevention | And 9 more authors.
Journal of the Neurological Sciences | Year: 2015

PPARδ belongs to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). We recruited 200 subjects (100 IS patients diagnosed by CTs or/and magnetic resonance imaging (MRI) and 100 normal healthy controls from Chinese Uyghur population) to assess the nature of the functional polymorphisms of PPARδ + 294T/C and any links with IS in this unique population. We found that the C allele of the PPARδ + 294T/C polymorphism was more common in controls than IS subjects in the Uyghur population. C allele carriage may be associated with an increased risk of IS in Uyghurs with a strong trend (OR 1.79, 95% CI: 1.11-2.89). Additionally, the PPARδ CC and TC genotypes were less frequent in Uyghur population than in Han population. Our population and ethnic-based study demonstrates that the PPARδ + 294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male (OR 1.99, 95%CI:1.06-3.72) and obesity populations (OR 2.36, 95%CI: 1.19-4.67), which were consistent with Tunisian Population. Moreover, total cholesterol, fasting blood glucose, waist-to-hip ratio, hypertension, history of heart diseases, and negative events may increase the risk of IS, with a trend for HDL to be a protective factor for IS in the Uyghur population. However, larger populations are warranted to validate our findings. © 2015 Published by Elsevier B.V. All rights reserved. Source


Tong Y.,Huazhong University of Science and Technology | Tong Y.,Tongji Medical College | Wang Z.,Huazhong University of Science and Technology | Geng Y.,Shenzhen Center for Disease Controls and Prevention | And 11 more authors.
Biochemical and Biophysical Research Communications | Year: 2010

Polymorphisms of G-572C and G-174C in the interleukin-6 (IL-6) promoter can affect both the transcription and secretion of IL-6 and may be involved in inflammation related to and the pathogenesis of ischemic stroke (IS). However, whether IL-6 polymorphisms are indeed risk factors for IS remains controversial. We recruited 748 Chinese IS patients diagnosed by magnetic resonance imaging (MRI) within 24 h of symptom onset and 748 normal healthy controls from two ethnic populations and performed two case-control studies in order to assess the nature of the polymorphisms of IL-6 and any links with IS. Common polymorphic loci in the IL-6 gene promoter were determined by TaqMan SNP genotyping assays. Multivariate logistic regression analysis was used to examine the association between IL-6 genotypes and a diagnosis of IS. We found that the C allele frequency at the -174 promoter region of IL-6 was extremely low in both IS patients and controls in both ethnic groups. The G allele of the promoter single nucleotide polymorphism (SNP) G-572C was more common in IS subjects than controls (P = 0.004, corrected for multiple testing) in the Han population but not in the Uyghur population. GC carriage therefore increased the risk of IS in the Han ethnic group (OR 1.45, 95% CI 1.13-1.86). In addition, the differences in GG and GC frequency between the two ethnic populations were significant. The C allele frequency at the -174 promoter region of IL-6 was rare in Chinese IS patients and controls from either ethnic group. We conclude that IL-6-572GC may be an independent risk factor for IS in the Chinese Han population. © 2009 Elsevier Inc. All rights reserved. Source


Tong Y.,Huazhong University of Science and Technology | Geng Y.,Shenzhen Center for Disease Controls and Prevention | Xu J.,Huazhong University of Science and Technology | Wang Z.,Huazhong University of Science and Technology | And 10 more authors.
Clinica Chimica Acta | Year: 2010

Background: Increasing evidences for the role of tumor necrosis factor-α (TNF-α) in the occurrence of ischemic stroke (IS) have shown that it belongs to pro-inflammatory cytokines and carries functional polymorphisms (TNF-α -238G/A and TNF-α -308G/A) in its promoter region, which affect their transcription rate and plasma cytokine level. We determined the association between these polymorphisms and the occurrence of IS in the Chinese Han and Uyghur populations. Methods: The TNF-α -238G/A and TNF-α -308G/A polymorphisms were determined by TaqMan SNP Genotyping assays in cases (n=748) and controls (n=748). Multivariate logistic regression analysis was used to show the association between the TNF-α genotypes and the IS events. Results: No significant difference was found in the association between TNF-α -238G/A and IS in both ethnic populations. The result showed that carriage of the TNF-α -308GA was a decreased risk of IS in both Han and Uyghur populations (OR:0.453, 0.213). In addition, the significant difference in GA frequency in TNF-α was found between the two ethnic controls (P=0.000). Conclusions: TNF-α -308 GA heterozygous may be an independent protective factor for IS in the Chinese Han and Uyghur populations. © 2010 Elsevier B.V. Source


Tong Y.,U.S. Center for Disease Control and Prevention | Tong Y.,Huazhong University of Science and Technology | Tong Y.,Shenzhen Center for Disease Controls and Prevention | Cai L.,Huazhong University of Science and Technology | And 12 more authors.
Cerebrovascular Diseases | Year: 2016

Background: PPARγ and PPARα belong to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). Methods: One thousand two hundred ninety-six subjects from the Chinese Han Population were chosen to assess the nature of the functional polymorphisms of PPARs and any links with IS. Multivariate logistic regression analysis was used to examine the association between PPARγ and PPARα genotypes and a diagnosis of IS. Results: Pro/Ala carriage may be associated with the decreased risk of IS in Hans (OR 0.542, 95% CI 0.346-0.850). The 162Val allele frequency at the DNA-binding region of PPARα was extremely rare in Chinese Han population. Conclusions: PPARγ 12Pro/Ala resulting in an amino acid exchange in N-terminal sequence may be an independent protective factor for IS in the Chinese Han population. However, more populations are warranted to validate our findings. © 2015 S. Karger AG, Basel. Source

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