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Zhang Z.-Q.,Shenzhen Beike Cell Engineering Institution | Zhang J.,Shenzhen Beike Cell Engineering Institution | Sun H.,University of California at San Francisco | Jiang S.,Shenzhen Beike Cell Engineering Institution | And 2 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Research on adult stem cells for the treatment of non-malignant disease grows quickly year-by-year. However, researchers are still working to identify potential indications for adult stem cells in non-malignant conditions OBJECTIVE: To provide consultative information on selecting potential indications of adult stem cells for non-malignant conditions. METHODS: On March 3rd, 2010, a search of the electronic database provided by the National Institute of Health website (http://www.clinicaltrials.gov) was conducted by using corresponding search formulas to define registered clinical research studies/trials in association with adult stem cells as an intervention in human subjects for non-malignant conditions. There was no restriction for language, research location, and research population race. RESULTS AND CONCLUSION: Of 1 540 studies identified in the initial search, 1 206 malignant conditions-related studies were excluded and a further 13 studies were excluded for lack of accordance with the searching purpose. A total of 321 research studies were entered into the analysis and reviewed. Among them, about a third of the trials were for cardiocerebrovascular diseases with the majority being ischemic cardiocerebrovascular diseases; the second third were for autoimmune disorders or graft versus host diseases after organ transplantation; the remaining third were for lower limb ischemic diseases (9%, 31/321), genetic disorders (9%, 31/321) and other diseases (22%, 73/321) of which the majority conditions were cirrhosis/hepatic failure, bone fusion operation, and type I & II diabetics. At present, clinical trials for adult stem cells in non-malignant diseases focus on the indications of cardiocerebrovascular diseases and peripheral vascular diseases. In addition, based on the theory of stem cells promoting tissue repair and regeneration, some of the studies were with a view to liver cirrhosis, bone fusion operation; and the idea of the immune downregulation of mesenchymal stem cells is still an important research concept.

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