Shenyang Northern Hospital and 83 Wenhua Road

Shenhe district, China

Shenyang Northern Hospital and 83 Wenhua Road

Shenhe district, China
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Cao P.,Shenyang Northern Hospital and 83 Wenhua Road | Liang G.,Shenyang Northern Hospital and 83 Wenhua Road | Gao X.,Shenyang Northern Hospital and 83 Wenhua Road | Wang X.,Shenyang Northern Hospital and 83 Wenhua Road | Li Z.,Shenyang Northern Hospital and 83 Wenhua Road
Archives of Pharmacal Research | Year: 2013

Three new nor-dammarane triterpenoids, 12β-O-acetyl-15α-hydoxy- 3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12β,28-O- diacetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12β-O-acetyl-15α,28-dihydoxy-3-oxo- 17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line. © 2013 The Pharmaceutical Society of Korea.


PubMed | Shenyang Northern Hospital and 83 Wenhua Road
Type: Journal Article | Journal: Archives of pharmacal research | Year: 2013

Three new nor-dammarane triterpenoids, 12-O-acetyl-15-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12,28-O-diacetyl-15-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12-O-acetyl-15,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line.

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