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Jia L.,Shenyang University | Dong Y.,Shenyang University | Yang H.,Shenyang University | Pan X.,Shenyang University | And 2 more authors.
Aging Clinical and Experimental Research | Year: 2011

Background and aims: The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). Methods: Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, geographic atrophy, and wet) and 34 healthy controls matched with age and sex. Results: Serum MDA levels were significantly higher in AMD (3.68±1.06 nmol/mL) than in controls (2.83±0.43 nmol/mL; p=0.000), and was significantly higher in wet AMD (3.79±0.79 nmol/mL) than in early dry AMD (3.26±0.99 nmol/mL; p=0.038). Serum SOD activity was significantly higher in AMD (87.12±13.22 U/mL) than in controls (79.91±11.80 U/mL; p-0.012), and slightly higher in wet AMD (89.52±16.25 U/mL) than in GA (83.62±9.75 U/mL; p=0.275) and early dry AMD (81.64±18.90 U/mL; p=0.093). There was a positive correlation between serum MDA levels and SOD activities in AMD patients and controls (r=0.320, p=0.002). Conclusions: The observed increase in SOD activity in our study may be related to increased MDA levels, as a compensatory regulation in response to oxidative stress in AMD patients. The present data also demonstrate that oxido-reduction disturbance may be hypothesized in the pathogenesis of AMD. ©2011, Editrice Kurtis.

Jia L.,Liaoning Medical University | Shen X.,Liaoning Medical University | Fan R.,Shenyang AIER Ophthalmology Hospital | Sun Y.,Heshi Ophthalmology Hospital | And 3 more authors.
Biomedical and Environmental Sciences | Year: 2011

The paper aims to evaluate the risk factors for age-related macular degeneration (AMD) in elderly Chinese population in Shenyang, a northeast city of China. A case-control study was conducted to investigate the risk factors for the prevalence of AMD. Ninety three AMD patients diagnosed by a complete ophthalmic examination were recruited as cases from the outpatient departments of two eye hospitals in Shenyang, while 108 normal subjects of similar age and sex were recruited as controls. A questionnaire was administered among both cases and controls. AMD patients aged 60 years and older accounted for 75.3. There were significantly higher educational levels, shorter smoking history, less sunlight exposure and cataract, and higher proportion of antioxidants intake in controls than in AMD patients. The frequency of intake of fruits, legumes, fish and shrimps was significantly higher in controls than in AMD patients. In a binary logistic regression analysis, smoking and cataract were the risk factors for AMD (OR: 4.44, 95 CI: 2.27-8.69; OR: 4.47, 95 CI: 2.26-8.85 respectively). The high educational background was a protective factor for AMD (OR: 0.761, 95 CI: 0.51-0.98). A low educational background, smoking and cataract are associated with a higher prevalence of AMD. © 2011 The Editorial Board of Biomedical and Environmental Sciences.

Sun Y.-D.,Shenyang University | Dong Y.-D.,Shenyang University | Fan R.,Shenyang AIER Ophthalmology Hospital | Zhai L.-L.,Shenyang University | And 2 more authors.
Annals of Nutrition and Metabolism | Year: 2012

Background/Aims: Supplementation with antioxidants is of special interest in preventing or delaying the development and progression of age-related macular degeneration (AMD). This investigation aimed to assess the effect of α- lipoic acid (LA) on serum lipids, serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with AMD. Methods: A total of 62 patients (50-75 years old) with early and intermediate dry form of AMD were randomly assigned to two groups, i.e. LA administration (n = 32) and placebo (n = 30). The levels of serum lipids and MDA and SOD activity were measured before and after LA and placebo intervention. Results: Compared with the parameters at baseline, serum total cholesterol (CHO), triglyceride and high- and low-density lipoprotein CHO (HDL and LDL) levels were not significantly different after LA and placebo intervention. There was a slight but statistically nonsignificant decrease in serum MDA levels and a statistically significant increase in serum SOD activity after LA intervention. There were no statistically significant differences in serum MDA levels or SOD activity after placebo intervention. Conclusion: The apparent increase in SOD activity caused by LA supplementation indicates that LA may have a possible preventive effect in the development of AMD through an antioxidant mechanism. Copyright © 2012 S. Karger AG, Basel.

Shen X.L.,Shenyang University | Jia L.H.,Shenyang University | Zhao P.,Shenyang AIER Ophthalmology Hospital | Fan R.,Shenyang AIER Ophthalmology Hospital | And 3 more authors.
Journal of Nutrition, Health and Aging | Year: 2012

Objective: To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area. Design: A case-control study. Participants: 56 AMD patients ( 21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied. Measurements: Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity-TAC ) were determined. Results: There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls. Conclusion: Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.

Yang J.-W.,Shenyang AIER Ophthalmology Hospital | Bu L.-M.,Shenyang AIER Ophthalmology Hospital | Zhang H.-W.,Shenyang AIER Ophthalmology Hospital | Liu J.,Shenyang AIER Ophthalmology Hospital
International Eye Science | Year: 2013

AIM: To observe the difference of treatment of amblyopia while children were kept in hospital or training in family. METHODS: The amblyopia children from nursery were examined, 90 patients (114 eyes) were randomly selected for the treatment group, and 90 patients (108 eyes) were selected as control in April 2011 in Shenyang City. All of the subjects refracted with 1% atropine, then wear glasses. The dominant eye was covered if both eyes differ by more than two lines. Amblyopia patients from the hospital group were treated in hospital, while the control group in family.Visual acuity was observed and the efficacy was evaluated monthly. The follow-up lasted for 6 months. RESULTS: After 6 months' treatment, for the hospital treatment group, invalid in 0 case, improvement in 18 cases (20%), almost recovery in 72 patients (80%). For the family treatment group at 6 months invalid 9 cases (10%) (2 cases gave up training), improvement in 22 cases (73%), almost recovery in 15 cases (17%). There was a significant difference (χ2=73.77, P<0.005). CONCLUSION: For the treatment of amblyopia, children kept in the hospital for treatment is better than treated in family. Copyright 2013 by the IJO Press.

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