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Zhang X.,Liaoning Medical University | Li W.,Shenyang | Zhang X.,The Fourth Peoples Hospital of Shenyang City | Zhao L.,Peking University | And 5 more authors.
BMC Medical Genetics | Year: 2014

Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic destructive inflammation in synovial joints. It is well known that genetic and environmental risk factors and their interaction contribute to RA pathogenesis. This study aimed to investigate the association between the critical polymorphisms in the tumor necrosis factor α (TNFα)-induced protein 3(TNFAIP3) gene and the risk of RA in a large northern Chinese Han population. Methods: A case-control study of 1280 RA patients and 1280 matched healthy controls was conducted. Results: This study showed that carriers of the rs2230926 TG genotype or rs10499194 CT genotype had an increased risk for RA compared with those carrying the wild genotype (rs2230926: OR = 1.48, 95% CI = 1.17-1.86, p = 0.001; rs10499194: OR = 2.00, 95% CI = 1.46-2.74, p < 0.001). The combined rs2230926TG/GG or rs10499194 CT/TT were associated with an increased risk of RA (ORs were 1.50 and 2.01, 95% CIs were 1.19-1.88 and 1.47-2.74, respectively, both p < 0.001). There was not significant association between rs13207033 polymorphism and RA risk. Subset analysis stratified to gender showed that the increased risks were significant among the genotypes TG, TG/GG of rs2230926 and CT, CT/TT of rs10499194 and the corresponding ORs were 1.42 (95% CI = 1.10-1.83, p = 0.006), 1.44(95% CI = 1.12-1.85, p = 0.004), 1.52(95% CI = 1.05-2.20, p = 0.026) and 1.52(95% CI = 1.06-2.19, p = 0.023) in the female population. Stratified analyses by age found that rs2230926(TG, TG/GG) and rs10499194(CT, CT/TT) polymorphisms were associated with RA risks in population ≤53 years old and among >53 years old only rs10499194(CT, TT, CT/TT) polymorphism had significant results. The interaction analysis suggested that individuals with both risk genotypes of the two SNPs have a higher elevated risk of RA than those with only one of them (ORs were 3.44 compared to 1.74 and 1.35). The haplotype results showed that individuals with the rs2230926G-rs13207033G-rs10499194C haplotype were associated with increased risks of RA (OR = 1.37, 95% CI = 1.08-1.74, p = 0.010). Conclusions: Rs10499194 and rs2230926 polymorphisms in the TNFAIP3 gene region may be susceptibility factors for rheumatoid arthritis in the northern Chinese Han population. © 2014 Zhang et al.; licensee BioMed Central Ltd.


PubMed | Shenyang, Xi'an Jiaotong University, Zhengzhou University, Clichy la Garenne and 3 more.
Type: Review | Journal: Alimentary pharmacology & therapeutics | Year: 2016

China may have the largest number of Budd-Chiari syndrome (BCS) cases in the world (at least 1914 original papers were published, and at least 20 191 BCS patients were reported). Considering the discrepancy in the clinical profiles and preferred treatment selection of primary BCS between the West and China, understanding its aetiology in these two different regions is very important.To review the data from large cohort studies and meta-analyses to illustrate the epidemiology of risk factors for BCS in the West and China.Relevant papers were identified by major English- and Chinese-language databases, conference abstracts, and by manual search.Risk factors reviewed include myeloproliferative neoplasms (MPNs) and their related gene mutations, anti-phospholipid syndrome, paroxysmal nocturnal haemoglobinuria (PNH), hyperhomocysteinaemia and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T mutation, factor V Leiden (FVL) and prothrombin G20210A mutations, inherited anti-thrombin, protein C and protein S deficiencies, pregnancy and puerperium, poverty, and family history.We examined the differences in the aetiological distribution of BCS between the West and China. Several recommendations should be considered in Chinese BCS patients: (i) screening for hyperhomocysteinaemia and MTHFR mutation should be regularly performed; (ii) screening for MPNs, PNH, and anti-phospholipid syndrome should be selectively performed; (iii) inherited anti-thrombin, protein C, and protein S deficiencies should be actively explored; (iv) screening for FVL and prothrombin G20210A mutations may be unnecessary; and (v) the clinical significance of pregnancy and puerperium, poverty with bacterial infections and unsanitary environments, and family history as possible risk factors should never be neglected.


Li Z.,Academy of Equipment Command and Technology | Liu S.,Academy of Equipment Command and Technology | Peng L.,Shenyang
Proceedings of 2011 International Conference on Computer Science and Network Technology, ICCSNT 2011 | Year: 2011

System-of-System counterwork is an important mode of information-based war. Under the conditions of informationization, the efficient of System-of-System combat takes representation of networked efficient based on mutual relations among the combat entities. The conception of combat System-of-System is confirmed and its logic structure is analyzed in the paper. On the basis of complex network theory, the transformation from characteristic parameters of network to System-of-System combat efficient of is realized through its network model built by the abstraction of operation units and process. It is expatiated through an example of efficient description in different command pattern of the combat System-of-System. A description and analysis method of networked efficient is put forward by the Perron Frobernius eigenvalue of the adjacency matrix. It is proved that the network efficient of combat System-of-System directly relates with the Perron Frobernius eigenvalue. © 2011 IEEE.


Dong G.-H.,Liaoning Medical University | Chen T.,Shenyang | Liu M.-M.,Liaoning Medical University | Wang D.,Liaoning Medical University | And 5 more authors.
PLoS ONE | Year: 2011

Background: Males and females exhibit different health responses to air pollution, but little is known about how exposure to air pollution affects juvenile respiratory health after analysis stratified by allergic predisposition. The aim of the present study was to assess the relationship between air pollutants and asthmatic symptoms in Chinese children selected from multiple sites in a heavily industrialized province of China, and investigate whether allergic predisposition modifies this relationship. Methodology/Principal Findings: 30139 Chinese children aged 3-to-12 years were selected from 25 districts of seven cities in northeast China in 2009. Information on respiratory health was obtained using a standard questionnaire from the American Thoracic Society. Routine air-pollution monitoring data was used for particles with an aerodynamic diameter ≤10 μm (PM 10), sulfur dioxide (SO 2), nitrogen dioxides (NO 2), ozone (O 3) and carbon monoxide (CO). A two-stage regression approach was applied in data analyses. The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM 10, SO 2, NO 2, O 3, and CO. The results showed that children with allergic predisposition were more susceptible to air pollutants than children without allergic predisposition. Amongst children without an allergic predisposition, air pollution effects on asthma were stronger in males compared to females; Current asthma prevalence was related to PM 10 (ORs = 1.36 per 31 μg/m 3; 95% CI, 1.08-1.72), SO 2 (ORs = 1.38 per 21 μg/m 3; 95%CI, 1.12-1.69) only among males. However, among children with allergic predisposition, more positively associations between air pollutants and respiratory symptoms and diseases were detected in females; An increased prevalence of doctor-diagnosed asthma was significantly associated with SO 2 (ORs = 1.48 per 21 μg/m 3; 95%CI, 1.21-1.80), NO 2 (ORs = 1.26 per 10 μg/m 3; 95%CI, 1.01-1.56), and current asthma with O 3 (ORs = 1.55 per 23 μg/m 3; 95%CI, 1.18-2.04) only among females. Conclusion/Significance: Ambient air pollutions were more evident in males without an allergic predisposition and more associations were detected in females with allergic predisposition. © 2011 Dong et al.


PubMed | Shenyang University
Type: | Journal: AIDS research and human retroviruses | Year: 2016

Forkhead box O (FOXO)1, FOXO3, interferon regulatory factor (IRF)4, X-linked inhibitor of apoptosis protein (xIAP), and E74-like factor (ELF)4 have been described as important regulators of T cell functions and differentiation. However, whether these molecules are associated with HIV-1 disease progression is still unknown. In this study, we showed that the levels of FOXO3, IRF4, and xIAP mRNA in rapid progressors (RPs) were significantly higher than in HIV-negative healthy controls (HCs). Moreover, FOXO3 expression was positively correlated with HIV-1 viral load and CD4


Ma Y.-N.,Liaoning Medical University | Chen T.,Shenyang | Wang D.,Liaoning Medical University | Liu M.-M.,Liaoning Medical University | And 2 more authors.
Archives of Medical Research | Year: 2011

Background and Aims: This study was carried out to assess and investigate the prevalence of overweight and obesity among preschool-age children living in northeast China using the World Health Organization (WHO), International Obesity Task Force (IOTF) and Centers for Disease Control and Prevention (CDC) standard criteria and to explore the differences in estimates by using the three reference standards. Methods: We used data from 8,653 preschool children with an average age of 5.02 years. Weight and height were obtained for each child and body mass index (BMI) was calculated. The prevalence of overweight and obesity was then determined using the CDC, IOTF and WHO guidelines. Results: According to the IOTF reference, 10.98% of the children were overweight and 6.08% were obese. The CDC reference classified 11.27% as overweight and 11.72% as obese. However, with the WHO reference, 10.93% were overweight and 13.81% were obese. There was significant gender difference in the prevalence of overweight and obesity based on the CDC and WHO references. According to age classification, differences in the frequencies of obesity in both boys and girls reached statistical significance using the three references, and the differences were gradually improved from the WHO to CDC and IOTF cut-off points. In this study, the WHO and the CDC references demonstrated a high level of agreement (kappa= 0.89). Conclusions: The results indicate overweight and obesity prevalence among preschool children in northeast China is comparable to some Western countries. The WHO reported a much higher prevalence of obesity compared to other references. Age, gender and method differences in the prevalence of overweight and obesity suggested a systematic evaluation of the preschool children in China. © 2011 IMSS.


Zhang X.,Liaoning Medical University | Zhang X.,The Fourth Peoples Hospital of Shenyang City | Li W.,Shenyang | Jiang L.,Liaoning Medical University | And 2 more authors.
PLoS ONE | Year: 2012

Background: To improve the early identification of autoimmune pancreatitis in China by a retrospective analysis of clinical data from AIP patients. Methodology/Principal Findings: The analysis included 36 patients admitted by the surgery department of our hospital from January 2003 to October 2011 whose postoperative pathological confirmations were consistent with the histological criteria of Honolulu Consensus Document. The clinical phenotypes associated with the histopathologic patterns of LPSP and IDCP were referred to as type 1 and type 2 of AIP, respectively. A retrospective analysis of clinical features, serological data, pathological findings and imageological records was performed in line with the subtypes of AIP. Type 1 showing a sex predilection (males) was commonly more dominant than type 2 in all AIP. Type 2 without a gender predilection was, on average, a decade younger than type 1. Type 1 was inferior to type 2 in ALT, ALP and γ-GT with statistical significance (P = 0.044, 0.025 and 0.013). Type 1 was inferior to type 2 in AST with difference close to statistical significance (P = 0.072). Histopathology revealed frequent lymphoplasmacytic infiltration with less frequent infiltration of neutrophils, eosinophils and fibroblasts. Diffuse and intensive interstitial fibrosis could be seen. The changes of pancreatic head were more frequently seen in type 2 than in type 1 (P = 0.05). Plasma cells staining of IgG4 at a density of over 30 or more cells per high-power field appeared to be a specific finding in China with type 1. Imageology found a diffusely or focally enlarged pancreas, most frequently a mass or enlargement in the pancreatic head, characteristic capsule-like rim, calcification or pancreatic calculus and cystic degeneration. Conclusions/Significance: AIP is a unique type of chronic pancreatitis and has distinctive serological, pathological and imageological characteristics, which should be used for differentiation from pancreatic cancer. © 2012 Zhang et al.


Zhang X.,Liaoning Medical University | Li W.,Shenyang | Zhang X.,Fourth Peoples Hospital of Shenyang City | Guo Y.,Liaoning Medical University | And 2 more authors.
Central-European Journal of Immunology | Year: 2013

Aim of the study: To identify TNFAIP3 SNP genotypes that confer a high risk of active rheumatoid arthritis (RA) through serological activity markers in the Han population of Chinese RA patients. Material and methods: A hospital-based untreated case study of 344 RA patients was conducted. Three polymorphisms were determined by the TaqMan SNP genotyping method. Serological activity markers were tested by regular detection means. Results: 1. ANOVA indicated a near significant difference in IgG between rs2230926 and rs13207033/rs10499194 (p = 0.062). A significant difference was identified in C3 between rs13207033 and rs2230926/rs10499194 (p = 0.047). 2. According to pairwise comparisons, the IgG levels among the patients with TT or TG genotypes at rs2230926 were significantly higher than among the patients with GG (p = 0.019 or 0.023, respectively). The C3 levels among the GG or GA patients at rs13207033 were significantly lower than among the patients with AA (p = 0.01 for both). 3. According to the Pearson χ2 test and ORs, the RF-positive rate among the patients with GG+TG at rs2230926 was lower than among the TT patients (OR = 0.36, 95% CI: 0.14-0.96; p = 0.034). The RF-positive rate for the TG patients was lower than for the TT patients (OR = 0.38, 95% CI: 0.14-1.00; p = 0.051). The anti-CCP antibody-positive rate among the AA+GA patients at rs13207033 was lower than among the GG patients (OR = 0.37, 95% CI: 0.13-1.04; p = 0.053). Conclusions: The TT or TG genotypes at rs2230926 and the AA or GG genotypes at rs13207033 may be high-risk genotypes for RA as indicated by serological activity indicators in the Chinese Han population.


Qindong F.,Shenyang | Shengyan D.,Shenyang
Arabian Journal of Geosciences | Year: 2015

Population growth and increasing economic activities cause a large amount of natural lands to be converted into artificial areas, which is one of the most direct and important drivers of ecosystem services (ES) degradation. To protect and recover ES, governments need more information about the relationship between land use and ecosystem services. Based on GIS platform, three periods of remote sensing images were processed to be land use maps. Then we analyzed the change of ecosystem services with land use from 2002 to 2013 by mathematical models. Result showed the whole ES degenerated from 2002 to 2013; all land use types except settlements and mining sites (SMS) had a positive effect on the total ES value in the whole period; the main land use type is agricultural landscapes, but in ecological sense, it was not the best efficient land use type. Subsequently, an improved Markov model was used to predict the ES change trendy with land use in the year of 2017. These information of ES change with land use can be used for making sustainable land use plan. © 2015 Saudi Society for Geosciences


Liu C.,Zhengzhou University | Du Y.,Zhengzhou University | Feng X.,Zhengzhou University | Zhang X.,Shenyang
Lecture Notes in Electrical Engineering | Year: 2016

Compared with the qualitative analysis, the quantitative analysis of VTEC (vertical total electron content) is more conducive to the modeling, forecasting, and correcting of ionosphere delay. With Empirical Mode Decomposition (EMD), the mean nighttime VTEC are investigated qualitatively using global grid ionospheric data from IGS (the International GPS Service for Geodynamic). The evaluation is done in this paper by comparing GIMs data with the quantitative analysis result and Klobuchar model. The final result indicates that the quantitative analysis result is reliable to describe and forecast the trend of the global mean nighttime VTEC in a solar activity cycle. © Springer Science+Business Media Singapore 2016.

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