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Cheng B.,Shengli Oil Field Central Hospital | Cai Q.,Tianjin Medical University | Wu Y.,Tianjin Medical University | Zhao Y.,Tianjin Medical University | And 5 more authors.
Oncology Letters | Year: 2015

The aim of the present study was to investigate the clinical characteristics and management of primary renal sinus tumors. We retrospectively analyzed three cases of primary renal sinus tumors. The first patient was a 33-year-old man who presented with right flank pain for 6 months. Based on the imaging results, the patient was diagnosed with renal sinus tumor. The second case was a 34-year-old woman who presented with sudden lumbago in the right flank for 3 days. The imaging results confirmed the diagnosis of right renal angiomyolipoma. The third case was a 55-year-old woman with flank pain, which had persisted for 1 year. The imaging tests revealed lipoma of the left renal sinus. All three cases underwent surgical procedures. The first case was diagnosed with benign angioleiomyoma following pathological analysis. During surgery, the tumor was ablated and the kidney was spared. The second case was scheduled for tumor enucleating, but a nephrectomy was performed due to serious hemorrhaging and a damaged renal pelvis. Pathological analysis identified angiomyolipoma. The third case was scheduled for lipoma enucleating; however, nephrectomy was performed as the tumor encapsulated the renal vascular pedicle. Pathological analysis revealed lipoma. In the three cases, no relapse over 3 years, 10 months and 4 years of follow-up, respectively, was observed. In addition, this review examined previous literature and concluded that the occurrence of tumors in the renal sinus is rare and the majority of such tumors are benign. Furthermore, cases are easily misdiagnosed as renal pelvic tumors. Computed tomography, magnetic resonance imaging and intravenous urography are the best imaging examination methods for differential diagnosis. In conclusion, surgery is the usual approach for the treatment of renal sinus tumors and radical nephrectomy should be performed for malignant tumors. © 2015, Spandidos Publications. All rights reserved.


Ding H.-F.,Shengli Oil Field Central Hospital | Zhang H.,Qingdao Municipal Hospital | Ding H.-F.,Shandong University | Li D.,Shandong University | And 4 more authors.
World Journal of Pediatrics | Year: 2014

Background: Oxidative stress is involved in the development of hypoxic-ischemic brain damage (HIBD). In this study, we investigated the therapeutic effects of placenta-derived mesenchymal stem cells (PD-MSCs) and explored the NF-E2-related factor-2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway in treating HIBD.Methods: P7 rats were subjected to hypoxic-ischemic brain injury and randomly divided into four groups (control, HIBD, HIBD+PD-MSCs, and HIBD+fibroblasts). Forty-eight hours after the induction of HIBD, 5×105 of PD-MSCs were injected into cerebral tissue in the HIBD+PD-MSCs group, while the same dose of fibroblasts were injected in the HIBD+fibroblasts group. Morris Water Maze, gross and pathological changes were tested at P28. The level of malondialdehyde (MDA) was detected in rats’ hippocampus. RT-PCR and western blot analysis were used to evaluate the changes of Nrf2/HO-1.Results: The HIBD group showed significantly longer escape latency and a lower frequency of original platform crossing in the Morris Water Maze compared with the control group. Rats receiving PD-MSCs showed significant improvement of HIBD. The pathological changes were evident after HIBD, but ameliorated in the PD-MSCs group. Compared with the control group, HO-1 and Nrf2 were up-regulated at gene and protein levels in the HI brain, beginning at 6 hours and peaking at 48 hours (P<0.05). The expression of HO-1 and Nrf2 in the PD-MSCs treatment group was more pronounced than in the HIBD group (P<0.01). PD-MSCs also decreased MDA production in the brain tissue.Conclusion: These results demonstrate that PD-MSCs have neuroprotective effect during the treatment of HIBD and that the mechanism may be partly due to alleviating oxidative stress. © 2014, Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg.


Wang Q.-Q.,Shengli Oil Field Central Hospital | Zhai Y.-J.,Shengli Oil Field Central Hospital | Zhang J.,Shengli Oil Field Central Hospital | Jia X.-G.,Shengli Oil Field Central Hospital | Wang J.-E.,Shengli Oil Field Central Hospital
International Journal of Ophthalmology | Year: 2011

AIM: To assess and compare the thicknesses of central fovea of macula and retinal nerve fiber layer in normal children and children with ametropic amblyopia. METHODS: Optical Coherence Tomography (OCT) was performed on 20 children (40 eyes) with ametropic amblyopia, the mean age was 6.15 ± 1.64 years old, spherical equivalent was 1.50-7.00D, axis oculi was 22.07 ± 0.97mm; OCT was also performed on 25 normal children (50 eyes), the mean age was 8.62 ± 2.42 years old, spherical equivalent was 0.57 ± 1.07D, axis oculi was 22.81 ± 0.72mm. Thicknesses of central fovea of macula and retinal nerve fiber layer were measured. In this study, t-test and Pearson test with SPSS 13.0 software were used to assess and compare the thicknesses of central fovea of macula and retinal nerve fiber layer in normal children and children with ametropic amblyopia. RESULTS: The average thickness of the fovea was 136.60 ±13.82 μm in normal eyes and 132.98 ±14.99 μm in amblyopic eyes. The difference between the two groups was not statistically significant (P > 0.05). The average thicknesses of the retinal nerve fiber layer was 110.40 ± 7.63 μm in normal eyes and 116.95 ±9.59 μm in amblyopic eyes. The difference between the two groups was statistically significant (P < 0.01). There was negative correlation between average thicknesses of the retinal nerve fiber layer and axis in normal eyes (r = -0.31, P < 0.05), but there was no significantly correlation in amblyopic eyes(r=0.12, P >0.05). CONCLUSION: Retinal nerve fiber layer thickness may be affected by ametropic amblyopia, but further histopathologic confirmation is needed.


Yu Y.-Q.,Shengli Oil Field Central Hospital | Liu H.-Q.,Shengli Oil Field Central Hospital | Chen T.-S.,Shengli Oil Field Central Hospital | Zhou F.,Shengli Oil Field Central Hospital | Lv Q.-J.,Shengli Oil Field Central Hospital
World Chinese Journal of Digestology | Year: 2013

Aim: To observe the clinical efficacy of immunoglobulin (IG) in the treatment of infection in patients with cirrhosis. Methods: One hundred and five cirrhotic patients with an infection were randomized into either a control group or an observation group. The control group received routine antibiotic treatment, while the observation group was given IG on the basis of routine antibiotic treatment and underwent efficacy evaluation using Child-Pugh scores. Serum total bilirubin (TB), albumin, alanine aminotransferase (ALT), total cholesterol (TC) and blood coagulation parameters were monitored. The rate of early infection control and incidence of complications were compared between the two groups. Results: For patients with a Child-Pugh score < 10, the rate of early infection control was not statistically significant between the two groups (P > 0.05). For patients with a Child-Pugh score between 10 and 15, the rate of infection control was significantly higher in the observation group than in the control group (84.00% vs 46.15%, P < 0.05). Severe infection occurred during therapy in two cases in the observation group and in eight cases in the control group, and there was no significant difference in the number of cases of severe infection occurring during therapy between the two groups (P > 0.05). In addition, 11 cases in the observation group and 13 cases in the control group were actively discharged from the hospital or died, and there was no statistically significant difference in the number of patients who were actively discharged from the hospital or died between the two groups (P > 0.05).Conclusion: IG can effectively improve the rate of infection control and reduce the incidence of complications during hospitalization and mortality in cirrhotic patients with a Child-Pugh score between 10 and 15. © 2013 Baishideng. All rights reserved.


Zhao X.,Shengli Oil Field Central Hospital | Lu X.-J.,Shengli Oil Field Central Hospital | Liu G.-Q.,Shengli Oil Field Central Hospital | Xu M.,Shengli Oil Field Central Hospital | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: The umbilical cord blood-derived mesenchymal stem cells are the hot spot in the field of stem cells, and there is no simple, effective culture method for the passage and amplification of umbilical cord blood-derived mesenchymal stem cells. OBJECTIVE: To explore a better culture method of human umbilical cord blood-derived mesenchymal stem cells in vitro with different media in the separation of mesenchymal stem cells at a confluent status. METHODS: Human umbilical cord blood was sterilely collected from full-term deliveries scheduled for cesarean section. They were assigned randomly into five groups: low-glucose culture medium group, high-glucose culture medium group, α-culture medium group, low-glucose culture medium + stem cell factor group, low-glucose culture medium + human marrow mesenchymal stem cells supernatant group. All culture medium used was Dulbecco's modIfied Eagle's medium. The cord blood mononuclear cells were isolated by lymphocyte separation medium. The monocytes of cord blood were inoculated into the culture medium containing 10% fetal bovine serum at 37 °C incubator with 0.05 volume fraction of CO2. Quantity and formation of cells were observed with invert microscope, and surface antigenic features were analyzed with flow cytometry. RESULTS AND CONCLUSION: (1) Comparison on number of adherent cells and survival rate of mesenchymal stem cells cultured for 48 hours: Number of adherent cells in the low-glucose culture medium + human marrow mesenchymal stem cells supernatant group, and low-glucose culture medium + stem cell factor group were significantly increased (P < 0.05), while the survival rate of cells was also increased compared with low-glucose culture medium group, high-glucose culture medium group and α-culture medium group (P < 0.05). (2) Comparison on growth status of mesenchymal stem cells at different culture time points: Cell proliferation in the low-glucose culture medium + human marrow mesenchymal stem cells supernatant group, and low-glucose culture medium + stem cell factor group was more rapid than that in low-glucose culture medium group, high-glucose culture medium group and α-culture medium group at 3, 6, 9, 12, 15, 18 and 21 days (P < 0.05). There was no significant difference between low-glucose culture medium + human marrow mesenchymal stem cells supernatant group and low-glucose culture medium + stem cell factor group. Experimental findings indicate that, co-culture with low-glucose culture medium + stem cell factor or human marrow mesenchymal stem cells supernatant can promote the in vitro isolation, culture and proliferation of human umbilical cord blood-derived mesenchymal stem cells.

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