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Devarajan K.,B.S. Abdur Rahman University | Devaraj S.,B.S. Abdur Rahman University | Balasubramanian K.K.,Shasun Pharmaceuticals Ltd. | Bhagavathy S.,B.S. Abdur Rahman University
Chemistry Letters | Year: 2015

Chromone-3-ylmethyl aryl ethers with unsubstituted orthopositions have been found to undergo a novel domino [1,3]-[1,3]-rearrangement to give 4′-hydroxyhomoisoflavones under thermal conditions while the para-substituted ethers lead to 2′-hydroxyhomoisoflavones involving an O- to C-[1,3]-migration, instead of the expected Claisen rearrangement. A few cis-homopterocarpans have been synthesized using the 2′-hydroxyhomoisoflavones obtained from the thermal [1,3]-rearrangement of chromene-3-ylmethyl aryl ethers. © 2015 The Chemical Society of Japan.


Mohanty S.,Industrial Research Ltd. | Reddy S.G.,Industrial Research Ltd. | Ramadevi B.,Jawaharlal Nehru University | Karmakar A.C.,Shasun Pharmaceuticals Ltd
Medicinal Chemistry Research | Year: 2015

The synthesis of a novel series of substituted 5-(aminomethylene)thiazolidine-2,4-diones was achieved using a wide range of heterocyclic models derived from eight drug-like molecules. The primary aim of this study was to combine medicinally known, biologically active molecules bearing a 2° amine functionality, such as terbinafine, fluoxetine, atomoxetine, cetirizine, risperidone, aripiprazole, ziprasidone, and clopidogrel, with a thiazolidinedione ring via an amino-methylene linker. By targeting this synergistic approach to compounds with skeletal, functional, and stereochemical diversity, we have developed a simple synthetic concept to enrich the thiazolidinedione collection with various biological activities. The biological activities of the newly synthesized 5-(aminomethylene)thiazolidine-2,4-dione derivatives were explored. All compounds were found to have antibacterial activity, with compounds bearing pyridine or piperazine moieties showing good to excellent antibacterial activity. Compounds with piperazine moieties were also found to show good antifungal activity, whereas none of the synthesized compounds showed high cytotoxic activity. © 2015 Springer Science+Business Media New York.


Saravanan G.,Shasun Pharmaceuticals Ltd. | Saravanan G.,Annamalai University | Selvaraju R.,Shasun Pharmaceuticals Ltd. | Nagarajan S.,Annamalai University
Synthetic Communications | Year: 2012

Thiazolidin-4-ones are known to exhibit diverse biological activities such as antimicrobial, anticancer, antidiarrheal, anticonvulsant, antidiabetic, antihistaminic, and antifungal activities. In the present investigation, a series of 2-haloacetamides was prepared by reacting chloroacetyl chloride with amines in dry benzene under reflux conditions. The formed 2-haloacetamides reacted with potassium thiocyanate in refluxing dry acetone to afford new 2-iminothiazolidin-4-ones. The 5-arylidene-2-imino-3 (napthalen-2yl)- thiazolidin-4-ones were prepared by condensing 2-iminothiazolidin-4-ones with substituted benzaldehydes. All the products were characterized by infrared, mass, and 1H and 13C NMR techniques. © 2012 Copyright Taylor and Francis Group, LLC.


Prabhu M.,Shasun Pharmaceuticals Ltd | Parthipan K.,Pondicherry University | Ramu A.,Madurai Kamaraj University | Chakkaravarthi G.,CPCL Polytechnic College
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

There are two independent mol-ecules in the asymmetric unit of the title compound, C 13H 9BrClN 3O 2, in which the dihedral angles between the benzene and pyridine rings are 8.23 (9)° and 52.84 (12)°. Both the molecules exist in an E configuration with respect to the C=N double bond. The two molecules in the asymmetric unit are linked via weak C-H⋯O hydrogen bonds. In both the molecules, an intramolecular O-H⋯N hydrogen bond generate an S(6) graph-set motif. In the crystal, intermolecular N-H⋯O and C-H⋯O hydrogen bonds generate bifurcated R 2 1(7) ring motifs. The crystal packing is further stabilized by weak inter-molecular N- H⋯O, N- H⋯N, C- H⋯O and π-π [centroid-centroid distance 3.615 (2) Å] interactions.


Mohanty S.,Dr. Reddys Laboratories Ltd | Roy A.K.,Dr. Reddys Laboratories Ltd | Kumar V.K.P.,Dr. Reddys Laboratories Ltd | Reddy S.G.,Dr. Reddys Laboratories Ltd | Karmakar A.C.,Shasun Pharmaceuticals Ltd
Tetrahedron Letters | Year: 2014

We describe a simple and efficient one-pot method for condensing bisulfite adducts of aromatic aldehydes directly with 2,4-thiazolidinedione catalyzed by acetic anhydride. The two main highlights of this study are the one-pot condensation of bisulfite adducts with 2,4-thiazolidinedione in non-aqueous media and the use of Design of Experiment to understand and optimize the reaction conditions. This methodology was then generalized using other active methylene compounds, such as malononitrile. © 2014 Elsevier Ltd. All rights reserved.


Patent
SHASUN PHARMACEUTICALS Ltd | Date: 2013-07-18

The present invention relates to a novel salt of (3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(1,2-benzisothiazol-3-yl)-piperazin-1-yl]methyl}cyclohexyl)methyl]hexahydro-1H-4,7-methanisoindol-1,3-dione and hydrates thereof, to methods for preparing the novel salt and its hydrates. In one aspect, the present invention provides a compound which is lurasidone dihydrochloride. In another aspect, the present invention provides a process for preparation of lurasidone dihydrochloride comprising: (i) mixing lurasidone free base in an organic solvent system; (ii) subjecting step (i) mixture to acid proton source; and (iii) isolating compound of lurasidone dihydrochloride.


Patent
Shasun Pharmaceuticals Ltd | Date: 2015-08-12

Stable non-alcoholic transdermal hydrogel of dexibuprofen was prepared by using a simple manufacturing process, and the experimental trials showed that the pH modifying agent, antioxidant and water miscible solvent are the essential excipients to obtain stable non-alcoholic transdermal hydrogel of dexibuprofen. The dexibuprofen hydrogel prepared using carbopol as a gelling polymer produced an opaque gel, whereas hydrogel prepared using hyroxypropyl methylcellulose (HPMC) as a gelling polymer produced a transparent gel. There was no significant changes observed with respect to physical description, pH, assay and particularly to the related substance values when the hydrogels were subjected to the stability study at accelerated condition (40 C./75% RH) for 3 months in laminated tubes.


Patent
SHASUN PHARMACEUTICALS Ltd | Date: 2015-02-02

A method for providing immediate and sustained release of ibuprofen to a subject, including administering, in a single dose, a modified release formulation of ibuprofen including a hydrophilic polymer, ibuprofen in solid dosage form uniformly dispersed in the polymer, and a dissolution additive and an inert formulation additive dispersed in the polymer. The hydrophilic polymer comprises a first hydroxypropyl methylcellulose (HPMC) having a viscosity of about 100 cps and a second HPMC having a viscosity between about 200 cps to about 50,000 cps. The solid dosage form is a monolithic tablet that demonstrates a mean ibuprofen plasma concentration in a subject greater than or equal to 6.4 g/ml within two hours of administration, and also demonstrates a mean ibuprofen plasma concentration in a subject greater than or equal to 6.4 g/ml for at least 8 hours after administration.


Trademark
Shasun Pharmaceuticals Ltd | Date: 2014-09-11

Medication, namely, drugs for the reduction of stomach acid and the prevention of heartburn and acid indigestion.


Trademark
Shasun Pharmaceuticals Ltd | Date: 2014-03-19

Polymer modified compounds for use in the manufacture of carriers for therapeutic and diagnostic agents.

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