Prabhu M.,Shasun Pharmaceuticals Ltd. |
Parthipan K.,Pondicherry University |
Ramu A.,Madurai Kamaraj University |
Chakkaravarthi G.,CPCL Polytechnic College |
Rajagopal G.,Government Arts College
Acta Crystallographica Section E: Structure Reports Online | Year: 2011
There are two independent mol-ecules in the asymmetric unit of the title compound, C 13H 9BrClN 3O 2, in which the dihedral angles between the benzene and pyridine rings are 8.23 (9)° and 52.84 (12)°. Both the molecules exist in an E configuration with respect to the C=N double bond. The two molecules in the asymmetric unit are linked via weak C-H⋯O hydrogen bonds. In both the molecules, an intramolecular O-H⋯N hydrogen bond generate an S(6) graph-set motif. In the crystal, intermolecular N-H⋯O and C-H⋯O hydrogen bonds generate bifurcated R 2 1(7) ring motifs. The crystal packing is further stabilized by weak inter-molecular N- H⋯O, N- H⋯N, C- H⋯O and π-π [centroid-centroid distance 3.615 (2) Å] interactions.
Mohanty S.,Dr. Reddys Laboratories Ltd |
Roy A.K.,Dr. Reddys Laboratories Ltd |
Kumar V.K.P.,Dr. Reddys Laboratories Ltd |
Reddy S.G.,Dr. Reddys Laboratories Ltd |
Karmakar A.C.,Shasun Pharmaceuticals Ltd.
Tetrahedron Letters | Year: 2014
We describe a simple and efficient one-pot method for condensing bisulfite adducts of aromatic aldehydes directly with 2,4-thiazolidinedione catalyzed by acetic anhydride. The two main highlights of this study are the one-pot condensation of bisulfite adducts with 2,4-thiazolidinedione in non-aqueous media and the use of Design of Experiment to understand and optimize the reaction conditions. This methodology was then generalized using other active methylene compounds, such as malononitrile. © 2014 Elsevier Ltd. All rights reserved.
Shasun Pharmaceuticals Ltd | Date: 2014-09-11
Medication, namely, drugs for the reduction of stomach acid and the prevention of heartburn and acid indigestion.
Shasun Pharmaceuticals Ltd | Date: 2015-08-12
Stable non-alcoholic transdermal hydrogel of dexibuprofen was prepared by using a simple manufacturing process, and the experimental trials showed that the pH modifying agent, antioxidant and water miscible solvent are the essential excipients to obtain stable non-alcoholic transdermal hydrogel of dexibuprofen. The dexibuprofen hydrogel prepared using carbopol as a gelling polymer produced an opaque gel, whereas hydrogel prepared using hyroxypropyl methylcellulose (HPMC) as a gelling polymer produced a transparent gel. There was no significant changes observed with respect to physical description, pH, assay and particularly to the related substance values when the hydrogels were subjected to the stability study at accelerated condition (40 C./75% RH) for 3 months in laminated tubes.
Shasun Pharmaceuticals Ltd | Date: 2014-03-19
Polymer modified compounds for use in the manufacture of carriers for therapeutic and diagnostic agents.