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Tudhope S.R.,Shasun Pharma | Bellamy J.A.,Shasun Pharma | Ball A.,Shasun Pharma | Ball A.,Syngenta | And 13 more authors.
Organic Process Research and Development | Year: 2012

A safe, practical and scalable process for manufacture of (-)-huperzine A has been developed and scaled up to manufacture several hundred grams of (-)-huperzine A with chemical and optical purity of >99%. The process consists of 11 chemical stages starting from commercially available materials with only nine isolation steps and no chromatography purification. This process provides a reliable and cost-effective source of synthetic (-)-huperzine A and its derivatives for pharmaceutical and nutraceutical markets. © 2012 American Chemical Society.


King A.G.,ABB | Hodgson D.,Shasun Pharma
Institution of Chemical Engineers Symposium Series | Year: 2012

This joint paper between Shasun Pharma Solutions and ABB outlines some of the challenges associated with hazardous batch process safety assessment and the benefits from carrying out a systematic study. Historically, Layer of Protection Analysis (LOPA) had been tried, bul was found to be inadequate for the situation. Shasun Pharma Solutions had relocated an exothermic batch reactor process to its site near Cramlington, Northumberland. In the relocation, a number of changes and improvements had been made to the process, so that the arrangements were not identical to those in the previous operating location. Therefore previous safety assessments were no longer applicable to the project. Dudley Northumberland is top tier COMAH site and Shasun had a legal obligation to ensure that the safeguards proposed reduced the individual risk of operating the new process to ALARP whilst also complying with the site's overall risk criteria. In doing so, Layer of Protection Analysis was tried but the challenges presented by the process led to the rejection of this method by the company and a lack of confidence in the results by the regulator. The alternative approach as described in this paper, builds on some of the guidance from the post-Bunce field PSLG report, applies it to the batch processing pharmaceuticals sector, and couples it with a more flexible assessment technique. This paper highlights the benefits of the approach used, and more importantly that it is applicable to all parts of the process sector, not just pharmaceuticals. © 2012 ABB Consulting and Shasun Pharma Solutions.


Fallan C.,University of Edinburgh | Quigley P.F.,Shasun Pharma | Lam H.W.,University of Edinburgh
Journal of Organic Chemistry | Year: 2011

Alkylidene malonates undergo efficient conjugate allylation upon treatment with allylstannanes or allylsilanes under the action of ytterbium catalysis. © 2011 American Chemical Society.


Zhao W.,Shasun Pharma
Chemical Reviews | Year: 2010

The applications of the most recently developed asymmetric Diels-Alder (D-A) reactions, [n + m] cycloaddition reactions, molecular rearrangements, free-radical reactions and transition-metal-catalyzed cyclization reactions toward the syntheses of APIs and natural products with bridge-containing ring systems were studied. The Diels-Alder cycloaddition reaction is one of the most fundamental synthetic transformations and has been the cornerstone in countless total syntheses. Lewis-acid-catalyzed asymmetric DA reactions have attracted great attention due to their ability to construct complex carbocyclic frameworks. 2,5-disubstituted cyclopentadiene is highly competent in Diels-Alder cycloadditions with a wide variety of dienophiles under very mild reaction condition. A combination of intramolecular Diels-Alder cycloaddition with intermolecular Diels-Alder cycloaddition, developed by Baran's group, constitutes a powerful tool to access a key tricyclic carbon skeleton.


Shasun Pharma | Entity website

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Shasun Pharma | Entity website

How can we help? We can help you find the right contact, as part of our full service we will be with you every step of the way


Advancement through innovation We are an award winning technology based service provider, aiming to be the preferred partner for drug substance and drug product development and supply. Latest News Case Studies Cryogenics Enhancing our capabilities in Cryogenic and High Temperature Processing Shasun Pharma Solutions have recently completed a major capacity enhancement which adds to our already broad ranging capabilities within the UK Read more How can we help? We can help you find the right contact, as part of our full service we will be with you every step of the way ...


Shasun Pharma | Entity website

Formulation From our state-of-the-art facility in Puducherry, India, Shasun offers a comprehensive range of Formulation development and manufacturing services for solid dosage products to our pharmaceutical customers around the world. Click here for more details on our Puducherry site The purpose built facility includes cGMP (current good manufacturing practice) pilot plant and commercial manufacturing equipment which is MHRA (Medicines and Healthcare products Regulatory Agency), PDMA (Prescription Drug Marketing Act), Health Canada and US FDA approved (Food and Drug Administration), with annual capacities of over 3 billion tablets and over 120 million capsules ...


Shasun Pharma | Entity website

Multi Product Facility Cuddalore A1/B SIPCOT Industrial Estate, Kudikadu, Cuddalore 607 005 Tamil Nadu, India Tel: +91-4142-239701, 239702, 239703, 239704 Fax: +91-4142-239709 E-mail: shacud@shasun.com Location Map


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