Garakani R.,Brown University |
Saidi R.F.,Shariati Hospital
International Journal of Organ Transplantation Medicine | Year: 2017
There has been ample of preclinical and animal studies showing efficacy and safety of using various cells, such as stem cells or T regulatory cells, after transplantation for tissue repair, immunosuppression or tolerance induction. However, there has been a significant progress recently using cell therapy in solid organ transplantation in small clinical trials. Recent results have been promising and using cell therapy in solid organ transplantation seems feasible and safe. However, there are more hurdles to overcome such as dose and timing of the infusions. Current studies mainly focused on live donor kidney transplantation. Expansion of current regimes to other organs and deceased donor transplantation would be crucial.
Salimzadeh H.,Health Faculty |
Delavari A.,Shariati Hospital |
Montazeri A.,Iranian Institute for Health science Research |
Mirzazadeh A.,Tehran University of Medical Sciences
International Journal of Preventive Medicine | Year: 2012
Background: Colorectal cancer (CRC) is the third most common malignancy in Iran. Limited data are available on knowledge and barriers in regard to CRC and screening tests in Iran. The aim of the study was to characterize knowledge, practice, and barriers toward CRC and its screening tests among an Iranian at-risk population. Methods: This cross-sectional study was conducted with participation of 200 individuals of both genders aged 50 years or older in a teaching hospital in Tehran, Iran. Data were collected via face-to-face interviews. A questionnaire containing demographics; knowledge about CRC and screening tests; screening practice; and reasons for not being screened was administered. The reliability alpha for knowledge items was 0.52. Results: The age of the participants ranged from 50 to 83 years (mean 60.13). Overall, 11% of the respondents reported prior screening by either fecal occult blood test (6.5%) or colonoscopy (4.5%). The majority of individuals had poor knowledge although respondents with prior screening obtained slightly higher score in comparison with nonparticipants in screening (26.74 vs. 23.24; P<0.05). Four commonly cited reasons for not having CRC tests were "doctor did not recommend the test," "did not think it was needed," "never think of the test," and "no symptoms/problems" which were reported by 29%, 26%, 20%, and 17% of the participants, respectively. Conclusion: It is necessary to design appropriate educational interventions to increase the general population's knowledge about CRC and screening before implementing preventive programs in Iran.
Panjavi B.,University of Tehran |
Sharafatvaziri A.,Shariati Hospital |
Zargarbashi R.H.,Shariati Hospital |
Mehrpour S.,University of Tehran
Journal of Pediatric Orthopaedics | Year: 2012
BACKGROUND: The most common congenital orthopaedic condition requiring treatment is clubfoot. The Ponseti method, which has improved the recurrence rate, is at present the most attractive method of treatment in the north of America. The purpose of this study was to evaluate the outcome of this method in an Iranian population and look for characteristics that may affect the treatment process. METHODS: A total of 78 patients (129 feet) were treated by precisely adhering to the technique originally introduced by Ponseti. Relapse was defined as any return of each of 4 clubfoot components according to the Dimeglio-Bensahel system. The mean follow-up period was 24.7 months and relapse was analyzed with respect to severity of primary disorder, number of casts, compliance with postcorrection bracing and stretching exercise, and educational level of parents. RESULTS: At the end of the follow-up, 24 (18.6%) clubfeet experienced relapse as defined. The mean time to relapse was 13.7 months, 30 feet had brace noncompliance, and stretching was not done for 35 feet. Significant association was detected between recurrence and severity of clubfoot, number of casts for complete correction, and bracing and stretching exercise noncompliance. CONCLUSIONS: The Ponseti method is a successful treatment protocol for idiopathic clubfoot. Its success rate will increase with use of abduction orthosis after complete correction and also by performing regular stretching exercises. LEVEL OF EVIDENCE: Therapeutic level II. Copyright © 2012 by Lippincott Williams & Wilkins.
Alavi-Moghaddam M.,Imam Hossein University |
Safari S.,Imam Hossein University |
Najafi I.,Shariati Hospital |
Hosseini M.,Tehran University of Medical Sciences
European Journal of Emergency Medicine | Year: 2012
OBJECTIVES: To evaluate the utility of urine dipstick test (UDT) for detecting rhabdomyolysis and acute kidney injury (AKI) due to crush injury. METHODS: All the rescued victims of the Bam earthquake who had a documented urine analysis and serum creatine phosphokinase and creatinine levels during their hospitalization period were eligible to enter the study. The sensitivity and the specificity, along with the positive and negative likelihood ratios, of UDT in detecting at-risk patients for rhabdomyolysis and crush-related AKI were calculated. RESULTS: Urine red blood cell count of 5 or less in blood-positive UDT, as a surrogate marker for myoglobinuria, was reported in 210 (31.7%) of the total 1821 urine analyses. Blood-positive UDTs (without considering the urine red blood cell count) had a 92.5% (95% confidence interval: 79.6-98.4) sensitivity in creatine phosphokinase, with a cut-off of 15 000 (IU/l). Comparing the results of the serum creatinine level and the urine blood, analysis showed that UDT had a sensitivity and a specificity of as high as 83.3 and 56.6% in detecting high-risk patients for AKI, respectively. CONCLUSION: UDT can be considered as an early screening tool for the detection and triage of patients at risk of developing AKI because of traumatic rhabdomyolysis after mass disasters. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Sorbi R.,Tehran University of Medical Sciences |
Sorbi R.,Shariati Hospital |
Aghamirsalim M.R.,Tehran University of Medical Sciences |
Aghamirsalim M.R.,Shariati Hospital
International Orthopaedics | Year: 2012
Purpose: Fragility fractures represent a major health problem, as they cause deformity, disability and increased mortality rates. Orthopaedic surgeons should identify patients with fragility fractures and manage their osteoporosis in order to reduce the risk of future fracture; therefore, orthopaedic surgeons' knowledge about managing fragile fracture should be evaluated. Methods: A questionnaire was administered to 2,910 orthopaedic surgeons to address the respondents' knowledge. The questions covered the topics of diagnosis, treatment and approach to a patient with a fragility fracture. The data-collection period for this survey spanned one year. Results: There were 2,021 orthopaedic surgeons who participated in this study. Less than 10% of the respondents included bone mass densitometry (BMD) when evaluating patients with fragile fractures 32% prescribed proper dosage of calcium and vitamin D; approximately 30% would refer if falling from a height was suspected. Conclusions: The majority of orthopaedic surgeons questioned lacked knowledge of fragility fracture management. This is reflected by limited knowledge of osteoporosis assessment and treatment in most areas. An appropriate method should be created to manage patients with fragility fractures to guarantee the patient the best possible care. © Springer-Verlag 2012.
Tavafian S.S.,Tarbiat Modares University |
Jamshidi A.R.,Shariati Hospital |
Mohammad K.,Tehran University of Medical Sciences
Clinical Journal of Pain | Year: 2011
Objective: This randomized clinical trial examined the efficacies of a group-based multidisciplinary rehabilitation program and oral drug treatment versus oral drug treatment alone in Iran. Methods: A total of 197 patients with chronic low back pain were randomized to either intervention group (n=97) receiving a group-based, 5-session multidisciplinary rehabilitation program plus oral medication or to control group (n=100) receiving just oral medication. At baseline and at 3 and 6-month follow-ups, patients filled out questionnaires on health-related quality of life (36-item Short-form General Health Survey) and disability Questionnaires (Quebec Disability Scale and Ronald-Morris Disability). Repeated measure analysis of variance was used to compare 2 groups during time. Results: The 2 groups were comparable regarding all baseline characteristics (P>0.05). There were significant differences within each group by time in terms of all subscales of 36-item Short-form (P<0.01) except for mental health (P=0.7). Furthermore, there were significant deferences between groups in terms of all domains of SF-36 scale except for general health (P=0.06), social function (P=0.08) and role emotional (P=0.7). Furthermore, according to the scores of Ronald-Morris Disability Questionnaire and Quebec Disability Scale, the disability of patients in the intervention group was improved over time significantly (P=0.01 and P<0.0001, respectively). Discussion: The findings revealed that the group-based multidisciplinary program could improve most domains of quality of life in chronic low back pain patients in the 6-month period. However, there were no significant differences between two groups in sub scales such as general health, social function and role emotional. © 2011 by Lippincott Williams & Wilkins.
Maghbooli Z.,Shariati Hospital |
Hossein-Nezhad A.,Shariati Hospital |
Shirzad M.,Tehran University of Medical Sciences |
Behzadi H.,Shariati Hospital
European Journal of Inflammation | Year: 2011
Osteoprotegrin (OPG), as a member of the TNF family is demonstrated to be a potential regulator of the endothelial function and angiogenesis by neutralization of nuclear factor kB ligand (RANKL). We investigated the OPG and RANKL gene expressions in circulating peripheral blood mononuclear cells (PBMCs) of Coronary artery disease (CAD) patients with different extents of coronary collateral development. In a cross-sectional study, 206 individuals with angiographically documented CAD were recruited. Severity of CAD was defined by the number of involved coronary vessels. The Rentrop scoring system was used to grade the extent of collateral development. Grade 0 or 1 collateralization was considered poor collateralization. RNA extraction and cDNA synthesis were performed. OPG and RANKL gene expressions were evaluated using quantitative real-time PCR. Among patients with CAD, 48.5% (100), 16.5%( 34) and 35%( 72) were considered to have one to three degrees of coronary artery involvement, respectively. The OPG and the ratio of OPG to RANKL expression were significantly elevated in patients with well-developed collateralization. In a logistic regression, severity of CAD was associated with a better collateral development, and OPG gene over expression was correlated with a better collateralization, independently of other variables. In conclusion, it seems that OPG might have an important role in prognosis of CAD; its up-regulation is parallel with CAD severity while it can enhance collateral development. Copyright © by BIOLIFE, s.a.s.
Moghbeli-Nejad S.,Tarbiat Modares University |
Mozdarani H.,Tarbiat Modares University |
Aleyasin A.,Shariati Hospital
Journal of Assisted Reproduction and Genetics | Year: 2012
Purpose: Induced chromosomal instability and micronucleus (MN) formation in blood lymphocytes of infertile men in comparison with fertile men exposed to gamma radiation was investigated. Methods: Blood samples of healthy and infertile donors were irradiated by 2 and 4 Gy Co-60 gamma-rays, then cultured in RPMI-1640 complete medium containing 1% phytoheamaglutinin (PHA) and incubated in a CO 2 incubator. Cytochalasin-B was added to the cultures at a final concentration of 4 μg/ml. Finally, harvesting, slide making, and analysis were performed according to standard procedures. Results: We observed a statistically significant difference between the frequencies of micronuclei in lymphocytes of infertile individuals, compared to healthy donors, before and after exposure to gamma rays. Although higher in azoospermia patients, the frequency of MN was not statistically different between infertile groups. Conclusions: This study indicates that genomic instability in infertile men could probably contribute to the development of an impaired reproductive capacity. © 2011 Springer Science+Business Media, LLC.
Pourmomeny A.A.,Isfahan University of Medical Sciences |
Zadmehre H.,Shariati Hospital |
Mirshamsi M.,Isfahan University of Medical Sciences |
Mahmodi Z.,Isfahan University of Medical Sciences
Otology and Neurotology | Year: 2014
OBJECTIVE: The aim of present study was to find a better procedure to prevent synkinesis in facial nerve palsy. DESIGN: A randomized clinical trial. SETTING: Clinical rehabilitation faculty and general rehabilitation centers. SUBJECTS: Twenty- nine patients with facial nerve palsy were selected via electrodiagnosis tests. INTERVENTION: The experimental group (n = 16) was treated with biofeedback electromyography, whereas the control group (n = 13) received common physiotherapy. All patients received 1-year treatment. MAIN OUTCOME MEASURES: Evaluation of facial grading scale before and after treatment and severity of synkinesia. RESULTS: At the end of treatment, there was a rise in facial grading system in both groups compared with baseline (p < 0.05, paired t test). There were significant differences in the facial grading system between 2 groups at the end of the study, but the experimental group showed better result than the other one. The number of patients with synkinesis and the severity of their synkinesis in the experimental group were lesser than those of the control group. CONCLUSION: Biofeedback therapy is more efficient than common physiotherapy. By using this approach, controlling and reducing synkinesis is more feasible. © 2014, Otology & Neurotology, Inc.
Hashemi H.M.,Shariati Hospital |
Parhiz A.,Shariati Hospital
Journal of Oral and Maxillofacial Surgery | Year: 2011
Purpose The most important part of facial bone fracture treatment is immobilization. Bandaging of the fractured mandible was the first immobilization device used in ancient Greece. Since then, various methods with different shapes and uses were introduced in the treatment of maxillofacial trauma patients. Intermaxillary fixation (IMF) with bone screws was first used in 1981. This technique has advantages, including quickness, ease of use, less trauma, and reduced risk of needle-stick injury. We analyze the advantages and disadvantages of this technique. Methods and Materials In a retrospective study on 73 patients requiring IMF, the complications of IMF screws were analyzed. Complications were divided into 2 groups: dental and nondental. Follow-up examinations consisted of clinical and panoramic radiographic examinations. Results In 24 teeth (6.5%) in 13 patients (17.8%), dental complications occurred. No dental treatment was needed in 4 patients (5.5%). The site at which dental complications occurred during operation in the majority of cases was the anterior mandible. Nondental complications occurred in 63 screws (16.9%) in 39 patients (54.2%). The most common complication was screw loosening. Screw soft tissue coverage occurred in 21 screws. Conclusion The use of IMF screws is simple and decreases the time required for surgery, but because of their complications, they still require punctuality. © 2011 American Association of Oral and Maxillofacial Surgeons.