Greater Noida, India
Greater Noida, India

Sharda University is a private university based in Greater Noida, Uttar Pradesh, India. Wikipedia.

SEARCH FILTERS
Time filter
Source Type

Priyanka,Sharda University | Singh R.,Sharda University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016

Among the most common chronic diseases in the world, Diabetes mellitus (DM) is an extremely studied and widely manifested multi-factorial disease which deliberately requires multi-modal therapeutic strategies [1]. It has an age-old history of being recognized and even symptomised in various cultures of the world majorly as glycosuria (sweet urine). Hence, the treatment strategies for DM have been in the process of development and documentation since a long time in traditional medicine systems. Back then the nature of drug used to be mostly unorganized and crude. The major difference now in the modern era is that the treatment strategies basically concentrate on identifying, isolating, modifying or searching alternatives of the lead compounds and exact active principles which attribute to the desired therapeutic nature of the plant. The aim of this paper is to acknowledge the various treatment methods available for Diabetes mellitus and to review the Traditional Indian herbs and plants which are most efficiently, safely and widely accepted medicament for DM and source of future lead compounds and family-wise segregation of these plants. This review is in total compliance with the strong and effective traditional medicinal systems of India. © 2016 The Authors.


Malik A.R.,Sharda University
International Journal of Civil Engineering and Technology | Year: 2017

A responsive building envelops are one that facilitates co-evolutionary interaction between the building, the inhabitant and the environment in a meaningful way. One of the primary performance mandates for high-performance envelopes has been energy optimization and reduction in the use of resources and their inhabitants. © IAEME Publication.


Sherwani A.F.,Sharda University | Usmani J.A.,Jamia Millia Islamia University | Varun,National Institute of Technology Hamirpur
Renewable and Sustainable Energy Reviews | Year: 2010

Sustainable development requires methods and tools to measure and compare the environmental impacts of human activities for various products viz. goods, services, etc. This paper presents a review of life cycle assessment (LCA) of solar PV based electricity generation systems. Mass and energy flow over the complete production process starting from silica extraction to the final panel assembling has been considered. Life cycle assessment of amorphous, mono-crystalline, poly-crystalline and most advanced and consolidate technologies for the solar panel production has been studied. © 2009 Elsevier Ltd. All rights reserved.


Tiwari M.,Sharda University
Journal of Cancer Research and Therapeutics | Year: 2012

Cancer is a leading cause of deaths. Millions of people are diagnosed with cancer every year. Many cancer cells have a protein all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody the researchers were able to get the nanoparticles to attach themselves to the cancer cells which may help us unravel the inner workings of a cancer cell and produce better treatments. In terms of drug delivery systems, nano particles enable unique approaches for cancer treatment. A large number of nanoparticle delivery systems have been developed for cancer therapy and currently they are in the preclinical stages of development. More recently developed nanoparticles are demonstrating the potential sophistication of these delivery systems by incorporating multifunctional capabilities and targeting strategies in an effort to increase the efficacy of these systems against the most difficult cancer challenges. This article reviews the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy.


Tiwari M.,Sharda University
Journal of Cancer Research and Therapeutics | Year: 2012

Cell death has been divided into two main types: programmed cell death, in which the cell plays an active role, and passive (necrotic) cell death. Senescence arrest, accelerated senescence and differentiation are also responses that can be induced in response to DNA-damaging agents. Apoptosis may occur as a primary event following chemotherapy, in which genes that regulate apoptosis will influence the outcome of therapy or, alternatively, as an event secondary to the induction of lethal damage that involves the subsequent processing of cellular damage. The particular type of response induced is highly dependent on the agent and dose employed, the type of DNA damage induced as well as the genetic and cellular phenotypes. It has been proposed that apoptosis may play a lesser role in tumor response to radiation in comparison with the induction of cell death through mitotic catastrophe or a senescence-like irreversible growth arrest. However, in comparison with the induction of apoptosis, there is a lack of as much definitive information on other cell death processes that occur in cancer cells in response to chemotherapeutic agents, including antimetabolites. This article reviews what is known about these processes at the present time in response to experimental or clinically used agents that are analogs of 5-fluorouracil, cytidine or purines, hydroxyurea, or that belong to the family of folate antagonists.


Singh S.,Sharda University
Cancer Chemotherapy and Pharmacology | Year: 2015

Purpose: Glutathione S-transferases (GSTs) family of enzymes is best known for their cytoprotective role and their involvement in the development of anticancer drug resistance. Recently, emergence of non-detoxifying properties of GSTs has provided them with significant biological importance. Addressing the complex interactions of GSTs with regulatory kinases will help in understanding its precise role in tumor pathophysiology and in designing GST-centered anticancer strategies. Methods: We reviewed all published literature addressing the detoxification and regulatory roles of GSTs in the altered biology of cancer and evaluating novel agents targeting GSTs for cancer therapy. Results: The role of GSTs, especially glutathione S-trans-ferase P1 isoform in tumoral drug resistance, has been the cause of intense debate. GSTs have been demonstrated to interact with different protein partners and modulate signaling pathways that control cell proliferation, differentiation and apoptosis. These specific functions of GSTs could lead to the development of new therapeutic approaches and to the identification of some interesting candidates for preclinical and clinical development. This review focuses on the crucial role played by GSTs in the development of resistance to anticancer agents and the major findings regarding the different modes of action of GSTs to regulate cell signaling. © Springer-Verlag Berlin Heidelberg 2014.


Tiwari M.,Sharda University
Journal of Cancer Research and Therapeutics | Year: 2012

Cancer can be considered a "developmental disorder" because it involves a disruption in the normal development of cells, in terms of both differentiation and proliferation (Dean M,1998). Cancer cells generally contain the full complement of biomolecules that are necessary for survival, proliferation, differentiation, cell death, and expression of cell type-specific function. Human Cancer diagnosis and classification by Microarray analysis has yet to be widely accepted despite the exponential increase in microarray studies reported in the literatures. Additionally, recent microarrays were inspired by the nucleotide-based technology, which have created to better define the molecular basis of malignancy which have shown that microarray have clinical utility in cancer diagnosis, risk stratification, and patient management.


Khatod D.K.,Indian Institute of Technology Roorkee | Pant V.,Indian Institute of Technology Roorkee | Sharma J.,Sharda University
IEEE Transactions on Power Systems | Year: 2013

In this paper, an evolutionary programming (EP) based technique has been presented for the optimal placement of distributed generation (DG) units energized by renewable energy resources (wind and solar) in a radial distribution system. The correlation between load and renewable resources has been nullified by dividing the study period into several segments and treating each segment independently. To handle the uncertainties associated with load and renewable resources, probabilistic techniques have been used. Two operation strategies, namely "turning off wind turbine generator" and "clipping wind turbine generator output", have also been adopted to restrict the wind power dispatch to a specified fraction of system load for system stability consideration. To reduce the search space and thereby to minimize the computational burden, a sensitivity analysis technique has been employed which gives a set of locations suitable for DG placement. For the proposed EP based approach, an index based scheme has also been developed to generate the population ensuring the feasibility of each individual and thus considerably reducing the computational time. The developed technique has been applied to a 12.66-kV, 69-bus distribution test system. The solutions result in significant loss reduction and voltage profile improvement. © 2012 IEEE.


Patil P.M.,Sharda University
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | Year: 2011

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases, such as halothane, sevoflurane, desflurane, the depolarizing muscle relaxant succinylcholine, and, rarely in humans, to stresses, such as vigorous exercise and heat. The syndrome is likely to be fatal if untreated. Early recognition of the signs of MH provides the clinical diagnostic clues. Diagnostic testing relies on assessing the in vitro contracture response of biopsied muscle to halothane, caffeine, and other drugs. Dantrolene sodium is a specific antagonist of the pathophysiologic changes of MH and should be available wherever general anesthesia is administered. The prevention and treatment of acute episodes of this disorder is of paramount importance to the oral and maxillofacial surgeon. The management of such patients in the oral and maxillofacial surgery setting and the recent advances in the field of MH are presented. © 2011 Mosby, Inc.


Patil P.M.,Sharda University
British Journal of Oral and Maxillofacial Surgery | Year: 2012

Our aim was to assess the influence of the presence and state of impaction of mandibular third molars on the incidence of fractures of the mandibular angle and condyle. We designed a retrospective study of patients who presented for the treatment of mandibular fractures from January 2006 to April 2011. The independent variables were the presence and degree of impaction of lower third molars, and the outcome variables were the incidence of fractures of the mandibular angle and condyle. The information was acquired from hospital records and panoramic radiographs. Personal data included age, sex, mechanism of injuries, and number of fractures of the mandibular angle and condyle. We studied 110 fractures of the mandibular condyle and 80 of the angle. The incidence of fractures of the mandibular angle was higher in the group with incompletely erupted third molars (37/80, p < 0.001) and that of condylar fractures was higher in the group without (67/110, p < 0.001). An incompletely erupted third molar reduces the risk of condylar fractures and increases the risk of fractures of the mandibular angle. © 2011 The British Association of Oral and Maxillofacial Surgeons.

Loading Sharda University collaborators
Loading Sharda University collaborators