Korde S.,Yerala Dental College |
Sridharan G.,Yerala Dental College |
Gadbail A.,Sharad Pawar Dental College |
Poornima V.,Yerala Dental College
Oral Oncology | Year: 2012
Nitric oxide (NO), a short-lived, endogenously produced gas, plays key role in various physiological as well as pathological processes. NO-inducing cell signaling events within the cell producing it and the diffusibility of it in other cells have led to the discovery of various physiological functions of NO including vasodilation, respiration, cell migration, immune response and apoptosis. On the other hand, excessive and unregulated NO synthesis has been implicated in many pathophysiological conditions including cancer. Research on NO, during the past few years is one of the growing areas in cancer biology. The high incidence of oral cancer and precancer has been linked with habits of tobacco chewing and smoking and NO has been said as the "messenger of death" in tobacco related diseases. NO seems to play a part in various stages of carcinogenesis from initiation to progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both, tumoricidal as well as tumor promoting effects and these depend on its timing, location and concentration. Further, NO has also been shown to have antitumor, chemopreventive and therapeutic abilities. Here is an overview in which efforts are made to understand the role of this molecule in oral carcinogenesis. © 2012 Elsevier Ltd. All rights reserved.
Rai A.,Rishiraj Dental College |
Datarkar A.,Kalmegh Dental College |
Borle R.,Sharad Pawar Dental College |
Rai M.,Rishiraj Dental College
Journal of Oral and Maxillofacial Surgery | Year: 2012
Purpose: The intention of this study was to compare the efficacy of eyelet wiring and direct interdental (Gilmer) wiring for achieving intermaxillary fixation (IMF). Materials and Methods: This study was a prospective randomized clinical trial. The study sample was derived from the population of patients who underwent IMF at the Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College, Wardha, India, between October 2008 and September 2010. The time required for placement and removal (in minutes) was compared between the eyelet wiring and direct interdental wiring techniques. Postoperative stability after achieving IMF was analyzed in the 2 groups. The plaque accumulation in both groups was evaluated using the Turesky-Gilmore-Glickman modification of the Quigley-Hein plaque index. Complications in the form of soft tissue injury, glove puncture, and trauma to the operator's finger were also recorded. Statistical analysis was performed with SPSS statistical software for Windows, version 8.0 (SPSS, Chicago, IL) using the χ 2 test and Student t test. Results: The mean working time for placement and removal of eyelet wiring (group I) was 18.00 minutes and 9.67 minutes, respectively. For direct interdental wiring (group II), it was 30.50 minutes and 23.12 minutes, respectively. The mean plaque index values were 1.78 and 2.54 for groups I and II, respectively, which signifies a higher plaque deposition in group II. No occlusal disturbance was seen in either group. The incidences of glove perforation, soft tissue trauma, and trauma to the operator's finger were higher in group II. Conclusions: Eyelet wiring is preferable to direct interdental wiring as evidenced by fewer complications, and requires a shorter operating time in patients with minimally displaced fractures. © 2012 American Association of Oral and Maxillofacial Surgeons.
Rai A.,Rishi Raj Dental College |
Datarkar A.,Kalmegh Dental College |
Borle R.M.,Sharad Pawar Dental College
Journal of Oral and Maxillofacial Surgery | Year: 2011
Purpose: The aim of this study is to see the efficacy of maxillomandibular fixation (MMF) screws with arch bars and to compare the plaque index in between 2 methods of MMF. Materials and Methods: This study is a randomized clinical trial. The study sample was derived from the population of patients who reported to Department of Oral and Maxillofacial Surgery, Wardha, Maharasthra, India between October 2006 and September 2008 and who required MMF. The patients were assessed for the time required in minutes for the placement and removal of screws and arch bar. Postoperative stability after achieving the MMF of both groups was analyzed and the plaque that was accumulated in both groups was evaluated by using TURESKYGILMOREGLICKMAN modification of the QUIGLEYHEIN plaque index. Statistical analysis was performed with SPSS statistical software for Windows, version 8.0 (SPSS, Inc, Chicago, IL) using the χ 2 test and Student t test. Results: The average working time for placement and removal of MMF screws is 18.67 minutes and 10.20 minutes, respectively, and for arch bars is 95.06 minutes and 29 minutes, respectively. The mean value of plaque index in group I is 1.88 and in group II is 2.69. It signifies that plaque deposition was more in group II. No occlusal disturbance was seen in both groups. Incidence of MMF screws causing damage to tooth root is 5.81% and incidence of screw breakage was seen in 3.33% of patients. Conclusions: Oral hygiene maintenance is better in patients with MMF screws than with arch bars with fewer complications and less operating time. Erich arch bars are the preferred choice in patients who require long-term MMF, because the screws start loosening after 5 to 6 weeks. © 2011 American Association of Oral and Maxillofacial Surgeons.
Korde Choudhari S.,Yerala Dental College and Hospital |
Chaudhary M.,Sharad Pawar Dental College |
Bagde S.,Yerala Dental College and Hospital |
Gadbail A.R.,Sharad Pawar Dental College |
Joshi V.,Yerala Dental College and Hospital
World Journal of Surgical Oncology | Year: 2013
Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both tumoricidal as well as tumor promoting effects which depend on its timing, location, and concentration. NO has been suggested to modulate different cancer-related events including angiogenesis, apoptosis, cell cycle, invasion, and metastasis. On the other hand, it is also emerging as a potential anti-oncogenic agent. Strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain are being investigated. However, further validation and experimental/clinical trials are required for development of novel strategies based on NO for cancer treatment and prevention. This review discusses the range of actions of NO in cancer by performing an online MEDLINE search using relevant search terms and a review of the literature. Various mechanisms by which NO acts in different cancers such as breast, cervical, gastric,colorectal, and head and neck cancers are addressed. It also offers an insight into the dichotomous nature of NO and discusses its novel therapeutic applications for cancer prevention and treatment. © 2013 Korde Choudhari et al.; licensee BioMed Central Ltd.
Choudhari S.K.,Yerala Dental College and Hospital |
Chaudhary M.,Sharad Pawar Dental College |
Gadbail A.R.,Sharad Pawar Dental College |
Sharma A.,VSPM Dental College and Hospital |
Tekade S.,Modern Dental College and Research Center
Oral Oncology | Year: 2014
Development of cancer in humans is a multistep process. Complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of endogenous and exogenous stimuli and important amongst this is generation of reactive oxygen species (ROS). Reactive radicals and non-radicals are collectively known as ROS. These can produce oxidative damage to the tissues and hence are known as oxidants in biological system. Many researchers have documented the role of ROS in both initiation and promotion of multistep carcinogenesis. To mitigate the harmful effects of free radicals, all aerobic cells are endowed with extensive antioxidant defence mechanisms. Lowered antioxidant capacity or the oxidant-antioxidant imbalance can lead to oxidative damage to cellular macromolecules leading to cancer. Oral cavity cancer is an important cancer globally and tobacco is the primary etiological factor in its development. Tobacco consumption exposes the oral epithelium to toxic oxygen and nitrogen free radicals that can affect host antioxidant defence mechanisms. Elevated levels of ROS and Reactive Nitrogen Species (RNS) and lowered antioxidants are found in oral precancer and cancer. Protection can be provided by various antioxidants against deleterious action of these free radicals. Treatment with antioxidants has the potential to prevent, inhibit and reverse the multiple steps involved in oral carcinogenesis. This review is an attempt to understand the interesting correlation between ROS and RNS mediated cell damage and enzymatic and non-enzymatic defence mechanisms involved in oral cancer development and its progression and the use of antioxidants in oral cancer prevention and treatment. © 2013 Elsevier Ltd. All rights reserved.
Korde S.D.,Sharad Pawar Dental College |
Basak A.,Jawaharlal Nehru Medical College |
Chaudhary M.,Sharad Pawar Dental College |
Goyal M.,Jawaharlal Nehru Medical College |
Vagga A.,Jawaharlal Nehru Medical College
Oncology | Year: 2011
Objective: Interaction between reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a crucial determinant in the etiology of oral squamous cell carcinoma (OSCC), and antioxidants protect against cellular and molecular damage caused by these. This study aims to evaluate ROS and RNS, together with the total antioxidant capacity (TAC), in serum and tissues of OSCC patients. Method: Total nitric oxide (TNO), malondialdehyde (MDA), and TAC were evaluated using a UV visible spectrophotometer in the serum of 30 controls, 30 precancer and 30 OSCC patients and in tissues of 10 controls and 30 OSCC patients. Results: MDA and TNO were significantly elevated with concomitant depletion of TAC in serum and tissues of OSCC patients when compared to controls. A significant positive correlation (p = 0.01), at different levels between TNO and MDA in OSCC patients, was found, which increased with the grade of OSCC. Conclusion: An increase in the levels of TNO, NO-mediated lipid peroxidation, resulting in an increase in MDA levels, the positive TNO-MDA correlation with a deranged antioxidant defense system as demonstrated by significantly low levels of TAC; when all these facts are taken together, we can conjecture that oxidative DNA damage, a vital phenomenon for carcinogenesis, occurs due to the interplay of ROS, RNS and TAC. Copyright © 2011 S. Karger AG, Basel.
Rawlani S.,Mahatma Gandhi Institute |
Rawlani S.,Sharad Pawar Dental College
Indian Journal of Community Medicine | Year: 2010
Objectives: To evaluate skeletal and non-skeletal fluorosis in patients living at endemic fluoridated areas and also the morphological changes in red blood cells (R.B.C.s). Materials and Methods: The cross-sectional study was conducted at Vidharbha region of Maharashtra, India. An ethical clearance was obtained from the concerned authorities. Fifty families were screened and 204 subjects who had dental/skeletal fluorosis were included in the study. The aims and objectives were explained to the study subjects of the village and biochemical, hematological and radiological assessment was done. The main source of drinking water in this area was tube well. The concentrations of fluoride in two different areas of same village were 4 and 4.5 ppm. Results: Prevalence of skeletal fluorosis and non-skeletal fluorosis in male patients was 56.87% (116) and in female patients (88) it was 43.13%. RBC count in male patients was 5.03 ± 0.49 while in female patients it was 4.70±0.47. With significant difference between male and female patients, P value was 0.003. Hb% in male patients was 12.44±1.76 and in female patients it was 11.31±1.34, showing significant difference between male and female patients P value 0.038. Alkaline phosphate level in male patients was 289.68 149.09 and in female patients it was 276.68±164.97. ESR count in male patients was found 11.41±8.75 and in female patients it was 13.29±7.37. Radiological finding of fluorosis patients shows thickening of inner and outer tables of skull bone in 83.92% of patients and only 7.84% of the patients were suffering from barrowing of long bone.
Panchbhai A.S.,Sharad Pawar Dental College
Journal of Cancer Research and Therapeutics | Year: 2015
The rarity of primary squamous cell carcinoma of salivary gland coupled with degree of morphological diversity of the salivary gland carcinomas make this group of lesions, one of the most interesting and challenging diagnosis in the head and neck region. Owing to clinical and the histological diversity, the histological examination of an entire specimen is needed for diagnosis. Although tumor grading is important, it is not an independent prognostic indicator; the diagnosis and management need careful consideration of clinical and pathological features together. There are very few reports of this tumor originating in the submandibular gland. The present article reports the rare case of primary squamous cell carcinoma of submandibular gland in a 58-year-old male with brief review.
Hande A.H.,Sharad Pawar Dental College |
Chaudhary M.S.,Sharad Pawar Dental College
Romanian Journal of Morphology and Embryology | Year: 2010
Objective: The objective of the present study was to assess the effect of tobacco chewing on buccal mucosa by using cytomorphometry. Study design: We compared the cellular diameter (CD), nuclear diameter (ND) and the ratio of nuclear diameter to cellular diameter (N/C) of buccal mucosa squames of normal subjects (N) with buccal mucosa squames of tobacco users without lesion (A), with tobacco-lime lesion (B), leukoplakia (C), and oral squamous cell carcinoma (D). The study group consisted of 125 patients divided into five groups (N, A, B, C and D) between the ages of 21 and 75 years. Results: The mean of the cellular diameter (in micrometers) of group N, A, B, C, and D was 72.86±5.26, 68.30±3.02, 62.13±3.29, 57.75±4.66, 54.51±4.66 respectively (p<0.01). The mean of the nuclear diameter (in micrometers) of group N, A, B, C, and D was 8.70±1.30, 8.98±1.08, 9.06±0.83, 9.12±1.06, and 11.04±1.46 respectively (p<0.01). The mean of the ratio of nuclear diameter to cellular diameter of group N, A, B, C, and D was 0.11±2.00, 0.13±1.82, 0.14±1.35, 0.16±3.11, 0.21±4.51 respectively (p<0.01). Univariate analysis of variance (ANOVA) showed a significant group effect for cellular diameter, nuclear diameter and ratio of nuclear diameter to cellular diameter. Multiple comparison tests by Tukey-HSD procedure revealed a significant decrease in the mean cellular diameter, increase in the nuclear diameter and ratio of nuclear diameter to cellular diameter. Conclusions: Cytomorphometric changes could be the earliest indicators of cellular alterations. There is progressive decrease in cellular diameter, increase in nuclear diameter and increase in ratio of nuclear diameter to cellular diameter in smears from all tobacco users, as compared to normal subjects. This indicates that there could be cause-effect relationship between tobacco and quantitative alterations.
Sen S.,Sharad Pawar Dental College |
Sen R.C.,Sharad Pawar Dental College
International Journal of Pharmacy and Technology | Year: 2015
Introduction: Aloevera is popularly known as Aloe barbadensis by taxonomists. It is being used since 1750 BC by Mesopotamians and Egyptians. This is awell-known medicament. Aim: The aim of the study was to evaluate clinically the efficacy of the Alovera mouthwash on common microbial flora of oral cavity. Materials and Method: This was a double-blind, randomized, parallel study design. 243 subjects were randomly assigned in three groups. Three groups were 99% Alovera mouthwash group, 0.12% Chlorhexidine gluconate group and distilled water group respectively. 0.12% Chlorhexidine gluconate was taken as positive control, whereas distilled water negative control. In each group 81 subjects were taken. Interventions consisted of 30 days therapy. The subjects were supervised to rinse approximately 15ml of mouth rinse for 30 seconds, twice per day for 30 days. The microbial assessment for saliva responsible for dental caries and periodontal disease was assessed prior and after treatment. Data were statistically analyzed by Statistical Package for Social Sciences (SPSS) 22 version developed by IBM Corporation. For the intra group comparison paired t-test was used and for the intergroup comparison unpaired t-test was used. The P value was set at <0.05. Results: The data shows that a mouthrinse based on the Alovera is equally effective in reducing microbial flora responsible for dental caries and periodontal disease. Conclusion: Microbial analysis indicates that 99% Alovera mouth wash has significant role in reducing the common oral mcro-flora responsible for dental caries and periodontal diseases. © 2015, International Journal of Pharmacy and Technology. All rights Reserved.