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Zhang N.,Shaoxing Shangyu Peoples Hospital | Jiang Z.,Zhejiang University | Ren W.,Shaoxing Shangyu Peoples Hospital | Yuan L.,Fudan University | Zhu Y.,Shaoxing Shangyu Peoples Hospital
OncoTargets and Therapy | Year: 2016

The WW domain-containing oxidoreductase (WWOX) gene is a tumor suppressor gene, the abnormal expression of which will lead to osteosarcoma tumorigenesis. Polymorphisms of the WWOX gene are associated with the risk of several malignancies. We hypothesized that genetic variations in the WWOX gene were related to osteosarcoma risk and outcome. In this case-control study, we recruited 276 young osteosarcoma patients and 286 controls from the East Chinese population and genotyped seven tag single-nucleotide polymorphisms (SNPs) of the WWOX gene (rs10220974C.T, rs12918952G.A, rs3764340C.G, rs1074963C.G, rs383362G.T, rs1424110A.G, and rs12828A.G). We discovered that two SNPs (rs3764340C.G and rs383362G.T) were associated with osteosarcoma risk. The CG genotype and dominant model of rs3764340 indicated elevated risk of osteosarcoma, and similar results were found for rs383362. Furthermore, rs3754340C.G was also related to grade and metastasis risk of osteosarcoma. Taken together, our results provide the first evidence that WWOX gene polymorphisms have the potential to be predictive factors for assessing risk and outcome of osteosarcoma. © 2016 Zhang et al.

Tu W.,Shaoxing Shangyu Peoples Hospital | Yu S.,Shaoxing Shangyu Peoples Hospital | Tang J.,Shaoxing Shangyu Peoples Hospital | Yu J.,Shaoxing Shangyu Peoples Hospital
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: To determine the incidence of diabetes and thyroid nodules and factors influencing them. Methods: A questionnaire was used for the epidemiological investigation of metabolic disorders, especially diabetes. Thyroid hormones and other indicator levels as well as ultrasound examinations were performed. Results: Of 842 cases, 43 had diabetes, with an incidence rate of 5.1%, while 799 cases were non-diabetic, accounting for 94.9%. The incidence rate of thyroid nodules was 81.4% (35/43) in diabetic patients and 70.7% (565/799) in non-diabetic patients. Statistical analysis showed that the pathogenesis of thyroid was not obviously associated with diabetes. A further analysis of clinical features and thyroid nodules in diabetic patients revealed that the morbidity of thyroid nodules was correlated with age but had no relation to gender. The incidence of thyroid nodules was 92.9% in patients > 60 years. The morbidity of thyroid nodules was not only associated with age but also gender in non-diabetic patients, with a relatively high probability in female patients > 60 years. Logistic regression analysis revealed that follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), and glutamate pyruvate transaminase (GPT) were risk factors for developing thyroid nodules in all subjects; for males aged > 60 years, TSH and thyroxine were risk factors; for female subjects, FSH, TSH and GPT were the main factors. Conclusions: Diabetes is not a risk factor for thyroid nodules but an age > 60 years is an important factor for high morbidity of thyroid nodules. © 2015, E-Century Publishing Corporation. All Rights Reserved.

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