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Chen D.,Shaoxing Second Municipal Hospital | Liu Q.-M.,Shaoxing Second Municipal Hospital | Tan W.-F.,Shaoxing Second Municipal Hospital
Journal of Practical Oncology | Year: 2015

Objective: To investigate the expressions of DOG-1 and CD117 in gastrointestinal stromal tumors (GISTs) and its clinicopathological significance. Methods: Eighty-four cases of GISTs were retrieved from pathology database and the clinicopathological characteristics were analyzed. Immunohistochemical method was used to detect the expression of DOG-1 and CD117. Samples of peritumoral smooth muscle and nerve tissue were used as normal control. Results: Eighty-four cases of GISTs were classified as spindle cell type (n=58), epitheloid type (n=10) and mixed type (n=16), and there was no significant difference in the expressions of CD117 and DOG-1 among different pathological types (P>0.05). All cases were graded as very low risk (n=15), low risk (n=40), intermediate risk (n=18) and high risk (n=11) according to biological behavior. The expression rates of DOG-1 and CD117 in very low and low risk GISTs were 94.5% and 92.7%, respectively; and those in moderate and high risk GISTs were 96.6% and 100.0%, respectively. With combined detection of DOG-1 and CD117 the expression rate was 100.0%. No samples of peritumoral smooth muscle or nerve tissue expressed DOG-1 and CD117. The expression of DOG-1 and CD117 was not correlated with pathological types, sites and clinical stages. Conclusion: In combination with clinicopathological characteristics (primary soft tissue tumors of gastrointestinal tract predominantly composed of spindle-shaped and/or epithelioid cells), immunohistochemical detection of DOG-1 and CD117 may be used as first-line markers for the diagnosis of GISTs. ©, 2015, Journal of Practical Oncology, Editorial Board. All right reserved.

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