Shanxi Xinghuacun Fen Jiu Group Co.

Shanxi, China

Shanxi Xinghuacun Fen Jiu Group Co.

Shanxi, China
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Ma Y.,Shanxi University | Qiao H.,Shanxi University | Wang W.,Shanxi University | Chen T.,Shanxi University | And 3 more authors.
International Journal of Food Properties | Year: 2014

Gas chromatography, gas chromatography/mass spectrometry, headspace/gas chromatography/mass spectrometry, and Dean's switch technology were used to identify the structure and investigate the transformation of aroma components of Chinese Fenjiu under different ages (from 0 to 30 years). Results showed that the variation in physicochemical properties of Fenjiu was due to the synergistic effects of volatilization of low boiling point matters, oxidation of dissolved oxygen, balance between esterification and hydrolysis, weak interaction among molecules, and involvement of metal elements extracted from storage vessels. By simulating the natural storage environment and utilizing high-gravity rotating packed bed technique, a multistage-spraying rotating packed bed was developed locally and successfully applied to liquor aging. The liquor treated by this method had qualities equivalent to the liquors aged naturally for more than two years. The present study reveals the traditional aging process of Chinese liquor and offers a perspective into the utilitization of high-gravity rotating packed bed technique as an alternative tool for liquor aging. Copyright © Taylor and Francis Group, LLC.


Gao H.-Y.,Shenyang Pharmaceutical University | Huang J.,Shenyang Pharmaceutical University | Wang H.-Y.,Shihezi University | Du X.-W.,Shanxi Xinghuacun Fen Jiu Group Co. | And 6 more authors.
Journal of Inflammation (United Kingdom) | Year: 2013

The study first evaluated the hepatoprotective effect of Zhuyeqing Liquor (ZYQL) against acute alcohol-induced liver injury in mice. Animals were administered orally with 50% alcohol 12 ml/kg at 4 h after the doses of ZYQL everyday for fourteen consecutive days except mice in normal group. The protective effect was evaluated by biochemical parameters including serum aspartate transaminase (AST), alanine transferase (ALT), total-bilirubin (TBIL) and reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) in liver tissue. The result were confirmed histopathologically and the expression of TNF-α in mice liver was determined by immunohistochemistry analysis. HPLC-PDA was used for phytochemical analysis of ZYQL, and the plant source of each compound was claritied by UPLC-TOF-MS. The result showed that pretreatment with ZYQL exhibited a significant protective effect by reversing the biochemical parameters and histopathological changes in a dose depended manner. HPLC analysis indicated that ZYQL contained flavonoids, iridoids, terpenoids and phenolic acids, which might be the active chemicals. This study demonstrated the hepatoprotective activity of ZYQL, thus scientifically supported the function of its health care. © 2013 Gao et al.; licensee BioMed Central Ltd.


Gao H.-Y.,Shenyang Pharmaceutical University | Li G.-Y.,Shihezi University | Wang H.-Y.,Shihezi University | Huang J.,Shenyang Pharmaceutical University | And 5 more authors.
Archives of Pharmacal Research | Year: 2015

An unprecedented new skeleton compound (1R, 10R, 11S)-10,11-dimethyl-4-formyl-2,9-dioxa-bicyclo [5.4.0] undeca-4,6-dien-3-one (1), monoterpenoids and monoterpene glycoside picrocrocinic ester (2), epijasminoside B (3) and 6′-O-(3-methoxyl-4-hydroxyl-coumaroyl)-epijasminoside B (4), along with 26 known compounds, were obtained from Zhuyeqing Liquor. These compounds were identified mainly by analyzing their NMR, HR-ESI-MS and CD data. The isolated compounds were screened against alcohol induced HepaG 2 toxicity for hepatoprotective assay. Compounds 10, 19, 21 and 26 displayed the highest potency against alcohol induced HepaG 2 toxicity with the cell viability ratio 41.21, 56.91, 67.69 and 70.32 % respectively. © 2014 The Pharmaceutical Society of Korea.


Gao H.-Y.,Shenyang Pharmaceutical University | Li G.-Y.,Shihezi University | Huang J.,Shenyang Pharmaceutical University | Han Y.,Shanxi Xinghuacun Fen Jiu Group Co. | And 6 more authors.
BMC Complementary and Alternative Medicine | Year: 2013

Background: Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects.Methods: The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in vivo in normal healthy mice and immunosuppressed mice treated with Cyclophosphamide (Cy, 100 mg/kg) by intraperitoneal injection on days 4, 8 and 12. ZYQL (100, 200 and 400 mg/kg) was administered via gavage daily for 14 days. The phagocytotic function of mononuclear phagocytic system was detected with carbon clearance methods, the levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in serum were detected with Enzyme linked immunosorbent assay (ELISA). Immune organs were weighed and organ indexes (organ weight/body weight) of thymus and spleen were calculated. Meanwhile, the activity of lysozyme (LSZ) in serum and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) in spleen tissue were measured.Results: ZYQL significantly upgrades the K value for clearance of carbon particles in normal mice treated with ZYQL (400 mg/kg) and immunosuppressed mice treated with ZYQL (100, 200 and 400 mg/kg) together with Cy (100 mg/kg) in vivo. The treatment of ZYQL (100, 200 and 400 mg/kg) effectively increased the activity of serum lysozyme as well as promoted the serum levels of IL-6 and IFN-γ in normal mice and immunosuppressed mice. Furthermore, ZYQL (100, 200 and 400 mg/kg) had an antioxidant effects in immune system by enhancing the antioxidant enzyme activity of SOD, CAT and GSH-Px in vivo. In addition, ZYQL (100, 200 and 400 mg/kg) effectively elevated the Cy-induced decreased organ index (thymus and spleen).Conclusions: The present work shows that the dose-dependent administration of ZYQL is capable of influencing immune responses, which implying that its valuable functional health may be attributed partly to its protective effects for the immune function. © 2013 Gao et al.; licensee BioMed Central Ltd.


Gao H.-Y.,Shenyang Pharmaceutical University | Wang H.-Y.,Shihezi University | Li G.-Y.,Shihezi University | Du X.-W.,Shanxi Xinghuacun Fen Jiu Group Co. | And 6 more authors.
Phytochemistry Letters | Year: 2014

Four new compounds methyl-6-(6-(3,4-dimethoxy)-benzalacryloyl-β-d- glucosyl)-O-β-d-glucopyranoside (1), (5R)-(2E)-5-hydroxy-2-methyl-hepta-2- ene-1,6-dione (2), 6″-O-trans-p-methoxy-coumaroyl genipin gentiobioside (3), and 7-methoxy-isobiflorin (4), along with 57 known compounds, were obtained from Zhuyeqing Liquor. These compounds were identified mainly by analyzing their NMR and HR-ESI-MS data. The anti-inflammatory activity of all these isolates against lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells were evaluated and compounds 1-61 exhibited various degrees in the anti-inflammatory activities screen. Among them, compounds 24, 26, 43 and 44 showed the best anti-inflammatory activities with the NO inhibition ratio 56.93%, 66.03%, 50.17% and 55.45%, respectively. It seems that all isolates were not active at less than 50 μM. © 2013 Phytochemical Society of Europe.

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