Shanxi Provincial Tumor Hospital

Taiyuan, China

Shanxi Provincial Tumor Hospital

Taiyuan, China
SEARCH FILTERS
Time filter
Source Type

Jing X.,Shanxi Medical University | Liang H.,Shanxi Medical University | Cui X.,Childrens Hospital of Shanxi and Women | Cui X.,Shanxi Medical University | And 3 more authors.
Clinica Chimica Acta | Year: 2017

Background Colon cancer associated transcript 2 (CCAT2), a novel long non-coding RNA (lncRNA), plays a key role in tumorigenesis. This meta-analysis systematically summarizes the relationship between CCAT2 and cancers. Methods A comprehensive, computerized literature search was conducted in PubMed, Cochrane library, Chinese National Knowledge Infrastructure, and Chinese Wan Fang database. Odds ratios (ORs), hazard ratios (HRs) and their 95% confidence interval (95% CI) were calculated to assess the effect size. A total of 9 studies were enrolled in this meta-analysis, which was performed by Revman5.3 software and Stata12.0. Results Our meta-analysis indicates that patients with elevated expression of CCAT2 are prone to developing distant metastasis (DM) (OR = 12.42; 95% CI = 5.77–26.74; P < 0.00001), which is associated with a tendency for lymph nodes metastasis (LNM) (OR = 3.60 95% CI = 1.65–7.87, P = 0.001). Further analyses reveal that patients with high CCAT2 expression have poorer overall survival (OS) (HR = 1.53, 95% CI = 1.15–2.02, P = 0.003, random-effects) and progression-free survival (PFS) (HR = 2.88, 95% CI = 1.81–4.56, P < 0.00001, fixed-effects). Conclusions Therefore, CCAT2 may be a potential novel biomarker for indicating clinical outcomes of human cancers. © 2017 Elsevier B.V.


Xu X.Q.,Shanxi Provincial Tumor Institute | Wang X.H.,Shanxi Provincial Tumor Hospital | Jing J.X.,Shanxi Provincial Tumor Institute
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2016

The increase in the incidence of papillary thyroid carcinoma (PTC) is a serious threat to public health. V-raf murine sarcoma viral oncogene homolog B(BRAF)(V600E) gene mutation is not only the common genetics factors, but also is the early event in process of thyroid carcinogenesis. We mainly illustrate the mechanism of BRAF(V600E) gene in genesis and development of PTC and the correlation of BRAF(V600E) gene mutation and the clinicopathological characteristics of PTC. Finally, we briefly summarize some scientific achievements about tyrosine kinase inhibitors targeted for BRAF(V600E) gene and their clinical prospect in terms of translation medicine concept. In summary, BRAF(V600E) gene is expected to be a new molecular marker of PTC, which will take a new hope for individualized precise treatment for patients with PTC.


Li J.,Shanxi Provincial Tumor Hospital | Wang Y.,Shanxi Provincial Tumor Hospital | Tian X.,Shanxi Provincial Tumor Hospital | Wang P.,Shanxi Provincial Tumor Hospital | And 4 more authors.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] | Year: 2014

OBJECTIVE: To investigate human papilloma virus (HPV) infection and typing in 7 640 cases of women in Shanxi province in order to provide theoretical basis for the prevention and treatment of the cervical cancer.METHODS: Totally, 7 640 cases of cervical cell specimens in Shanxi provincial tumor hospital, screening and physical examination from 2012 January to 2013 May and 23 HPV genotypes were analyzed by PCR and reverse dot blot gene chip technology.RESULTS: A total of 1 441 cases of patients with HPV infection were to be found in 7 640 cases of women with an average age of (42.26 ± 19.15)years old. The total infection positive rate, infection rate of high-risk HPV, infection rate of low-risk HPV and infection rate of mixed high and low risk were 18.86% (1 441/7 640), 16.03% (1 225/7 640, including multiple high-risk of HPV infection), 4.88% (373/7 640, including multiple low-risk of HPV infection) and 2.05% (157/7 640) respectively. The rate of high-risk HPV infection was 85.01% (1 225/1 441) in total infection positive women. The most common subtype was HPV16 (34.70%, 523/1 507) and followed by HPV58 (11.48%, 173/1 507), HPV18 (7.43%, 112/1 507), HPV33 (7.10%, 107/1 507), HPV56 (6.04%, 91/1 507) and HPV52 (5.51%, 83/1 507) respectively in tested 18 high-risk HPV subtypes, and there was no HPV82. The most common subtype was HPV43 (38.13%, 151/396) and followed by HPV42 (22.22%, 88/396), HPV81 (20.45%, 81/396), HPV6 (11.87%, 47/396) and HPV11 (7.32%, 29/396) respectively in tested 5 low-risk HPV subtypes. The HPV infection positive rates were significantly different in different age groups and HPV total infection rate, high-risk infection rate in 41-50 year-old age group was the highest, 23.23%. The infection rates of single subtype of HPV and single high-risk subtype of HPV were 75.71% (1 091/1 441) and 61.35% (884/1 441) respectively in all cases of infection women and single high-risk subtype infection rate was 81.03% (884/1 091) in all cases of single subtype infection women. The infection rate of multiple subtype of HPV was 24.29% (350/1 441) in all cases with HPV infection. The double infections was most common (18.18%, 262/1 441) in which the women of double high-risk infections of HPV were 151 cases (10.48%, 151/1 441). The rates of double infection, triple infection and quadruple or more infection of HPV were 74.86% (262/350), 20.29% (71/350) and 4.89% (17/350) respectively in all cases with HPV multiple infection. The positive rates of HPV infection in different age groups were obvious difference. The positive rate of single infection of HPV was 17.80% (574/3 224) in cases of 41-50 years old group which higher than that in other groups(χ² = 20.18, P < 0.05).CONCLUSION: The more common high-risk HPV subtype is HPV16, HPV58, HPV18, HPV33, HPV56 and HPV52 and low-risk HPV subtype is HPV43, HPV42 in Shanxi province. HPV infection is most common in the age group of 41- 50 years old female.


Wang G.P.,Shanxi Provincial Tumor Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To analyze the different risks of cardia neoplasms in the immediate relatives of the cardia cancer patients, through a case-control study. A case-control study was adopted on 772 cases and 772 controls, and relative risk (RR) were measured to compare the results from paternal or matrilineal groups. (1) Risk of the 1st grade kinship to the male cardia-cancer-patient group was obviously higher than that of the control group with RR = 2.61 (95%CI: 1.44 - 4.73, P < 0.01). (2) The risks of both paternal (P < 0.05) and matrilineal (P < 0.05) in the male cardia-cancer-patients were obviously higher than that of the control groups while the risk of those male cardia-cancer-patients in the paternal was higher than that of the control group (P < 0.05), so as the case for female patients in the matrilineal group (P < 0.05). (3) Data from the 1st grade kinship of cardia-cancer-patient group showed that parents and siblings had a higher risk than the control group (P < 0.05). (4) No significant genetic differences were found between the paternal of either the cancer group or the control group (P > 0.05), but statistical difference was observed that the risk of someone being the matrilineal of the cancer group was higher than that of the control group (P < 0.05). The risks of cardia-cancer were higher in the 1st grade kinship, which including parents, brothers, sisters, maternal grandmother, mother, and maternal aunt. It was suggested that prevention programs should be focused on both earlier detection and treatment of the patients. New strategy for cancer prevention also need to be further developed.


To assess the effects of ischemic postconditioning, remote ischemic postconditioning and naloxone postconditioning on focal cerebral ischemia-reperfusion injury in rats. A total of 110 adult SD rats were randomly divided into 5 groups (n = 22 each). The focal cerebral ischemia-reperfusion injury was induced by a 90-minute occlusion of right middle cerebral artery (MCA) and a 24-hour reperfusion sequentially. Group 1 was of ischemia-reperfusion control; Group 2 ischemic postconditioning induced by three 30-second cycles of MCA occlusion followed by a 30-second reperfusion; Group 3 remote ischemic postconditioning performed via a transient occlusion of right femoral artery at 5 min before the initiation of reperfusion; Group 4 naloxone postconditioning with naloxone 10 mg/kg intraperitoneally injected at the initiation of reperfusion; Group 5 combined ischemic, remote ischemic & naloxone postconditioning performed simultaneously in accordance with the methods used in Groups 2, 3 & 4. The neurologic deficit scores (NDS) were obtained at 2 h & 24 h post-reperfusion. At 24 h post-reperfusion, the anesthetized rat was sacrificed by decapitation and the brain rapidly extracted to assess the size of cerebral infarct (n = 10), detect the cerebral expression of microtubule-associated protein-2 (MAP2) (n = 6), measure the plasma volume of cerebral tissues and quantify the diameter and segment length of cerebral microvessel (n = 6). There were no significant differences in the heart rate (HR) and mean arterial pressure (MAP) among the above five groups at all observed time points (P > 0.05). At 24 h post-reperfusion, the percentage of ischemic cerebral infarct size was 43% ± 6%, 31% ± 4%, 32% ± 5%, 28% ± 6% & 21% ± 7% in ipsilateral hemisphere area (i.e., cerebral infarct severity) in Groups 1-5 respectively. Compared with Group 1, the levels of NDS and cerebral infarct severity significantly decreased at ischemic side in Groups 2-5 (P < 0.05). And the cerebral expression of MAP2, plasma volume of cerebral tissues, diameter and segment length of cerebral microvessel significantly increased at the ischemic side (all P < 0.05). However, there were no significant differences in the above-mentioned parameters at ischemic side among Groups 2, 3 and 4 (all P > 0.05). The parameters of NDS, cerebral infarct severity, cerebral expression of MAP2 and plasma volume of cerebral tissues in the ischemic side significantly increased in Group 5 compared with Groups 1, 2, 3 and 4 (all P < 0.05). The diameter and segment length of cerebral microvessel at ischemic side were not different among Groups 2, 3, 4 and 5 (all P > 0.05). In focal cerebral ischemia-reperfusion rats, ischemic, remote ischemic and naloxone postconditioning may produce significant neuroprotective effects of reduced cerebral infarct severity and improved neurologic dysfunctions. A combination of three postconditioning approaches enhances the above neuroprotective effects.


Han S.,Xi'an Jiaotong University | Li L.,Xi An Fourth Peoples Hospital | Jia X.,Xi'an Jiaotong University | Ou W.,Xi'an Jiaotong University | And 4 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2012

The aim of this study is to develop a new screening method, molecular beacon (MB) imaging, for detection of cervical cancer and to determine its potential clinical applications by examining the sensitivity and specificity of target-specific MBs. Two target-specific molecular beacons were designed and synthesized for survivin and HPV16E6 mRNA. The two designed MBs and a random control MB were used to detect cervical cancer cell lines and a normal cell line. RT-PCR and western blot targeting survivin and HPV16E6 was done for verification. Furthermore the sensitivity and the specificity of the survivin and HPV16E6 mRNA MBs were examined in smears from 125 clinical cervical patients. The survivin and HPV16E6 mRNA MBs generated a strong fluorescence signal in cervical cancer cell lines, but not in the normal cell line, while the random control MB did not generated any signal in both cell lines. The fluorescence intensity correlated well with the gene expression levels in the cells determined by reverse transcription-PCR and Western blot analysis. The clinical sensitivity and the specificity of survivin MB-FITC were 72.5 and 77% while those of HPV16E6 MB-Cy3 were 96.1% and 71.6%, respectively. A parallel test of the two target MBs showed that the sensitivity increased to 98% and the specificity was 70.2%. The survivin and HPV16E6 mRNA MBs showed good reliability and sensitivity. They have great potential for clinical use in cervical cancer screening. Copyright © 2012 American Scientific Publishers.


Zhao H.-H.,Shanxi University | Yan K.-L.,Shanxi Provincial Tumor Hospital | Liu H.-R.,Shanxi University
Chinese Traditional and Herbal Drugs | Year: 2015

Objective: To optimize the inclusion process of decomposed volatile oil from Atractylodes macrocephala (DVOA) with hydroxypropyl-β-cyclodextrin (HP-β-CD). Methods: The inclusion complex was prepared by the freeze drying method. The preparation process was evaluated using fluorescence spectrophotometry. The inclusion process conditions were screened by the orthogonal test, with the inclusion ratio and oil ratio as indexes, and mass ratio between HP-β-CD and DVOA, inclusion temperature and inclusion time as the impacting factors. The inclusion complex was characterized through ultraviolet-visible spectra (UV-vis), fluorescence spectra (FL) and microscopic imaging, and the stability test was performed. Simultaneously, the chemical composition in DVOA before and after inclusion was analyzed by GC-MS technique. Results: The DVOA and HP-β-CD had formed inclusion complex, the optimal inclusion conditions were as follows: The mass ratio of HP-β-CD to DVOA was 10:1, the inclusion temperature was 30℃, the inclusion time was 2.0 h, and the ratios of average inclusion and oil were 73.32% and 10.43%, respectively. The chemical composition of DVOA was consistent before and after inclusion, the inclusion just had the slight effects on proportion of each component. Conclusion: The preparation process of DVOA/HP-β-CD inclusion complex under the optimal conditions is reasonable, stable, and feasible, and can provide the reliable experimental basis for the anti-tumor new drug research and development of DVOA. © 2015, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved.


Han F.,Shanxi Provincial Tumor Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To explore the relationship between esophagus cancer patients and both environmental and genetic factors, through analyzing the data on birth orders from esophagus cancer patients of Shanxi province. Both Greenwood and Haldane methods on birth order were used to study the 1101 cases with esophagus cancer from Shanxi province. All the patients had received surgery and were diagnosed, by pathological evidence. First certificates of the patients were confirmed through the standard genetic epidemiologic investigation. Birth order was investigated on probands of the 1101 cases with esophagus cancer and their 44 siblings. form the Greenwood method showed that there was a tendency for cases with esophagus cancer in birth orders First to Third. However, the Haldane method showed that the results were quite different between actual value and the average theory value of 6A (6A((actual value)) = 17 118, X -(6A(average theory value)) = 19 290, X = |6A-X -(6A)|/V(6A) = 7.63, X > 2) which suggested that the birth order had some effects on the occurrence of esophagus cancer. In addition, the actual value of 6A was lower than the theoretic average value, and the parents at younger productive age or baby at the first birth was easy to develop esophagus cancer. Esophagus cancer was related with the birth order, especially at early order, which was not consistent with the national reports on esophagus cancer. from this study suggested that there were certain effects of environmental risk factors on esophagus cancer patients.


Wei S.,Tianjin Medical University | Hao C.,Tianjin Medical University | Gong L.,Tianjin Medical University | Hu C.,Shanxi Provincial Tumor Hospital | And 2 more authors.
Thoracic Cancer | Year: 2012

Background: We aimed to identify the factors determining long-term survival after surgical management for bronchial typical carcinoid (TC) and atypical carcinoids (AC) and to compare the clinical outcome of the different surgical strategies used in the two periods of 1980-1994 and 1995-2005. Methods: Records of 82 patients with an initial pathological diagnosis of bronchial carcinoid tumor who underwent surgical management from January 1980 to December 2009 were reviewed. Tumors were classified as TC or AC using the 2004 World Health Organization criteria. Results: There were 60 TC and 22 AC. Surgical procedures included lobectomies, sleeve or bronchoplastic resections, pneumonectomies, wedge resections, and segmental resections. Significantly fewer pneumonectomies and more sleeve and bronchoplastic resections were performed after 1994. The prognosis was more favorable for TC than AC. Comparing lymph node status N0 with N1 + N2, 5- and 10-year survival was 92% and 85% vs. 61% and 41%. No patient with lymph node involvement survived more than 15 years. Conclusions: Tumor subtype and lymph node status have the greatest impact on long-term survival following surgery. AC and/or regional lymph node metastases have the worst prognosis. Formal anatomic and tissue-saving lung resection plus systematic radical mediastinal lymphadenectomy for TC and AC should be standard. © 2011 Tianjin Lung Cancer Institute and Blackwell Publishing Asia Pty. Ltd.


PubMed | Shanxi Provincial Tumor Institute and Shanxi Provincial Tumor Hospital
Type: Journal Article | Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2016

The increase in the incidence of papillary thyroid carcinoma (PTC) is a serious threat to public health. V-raf murine sarcoma viral oncogene homolog B(BRAF)(V600E) gene mutation is not only the common genetics factors, but also is the early event in process of thyroid carcinogenesis. We mainly illustrate the mechanism of BRAF(V600E) gene in genesis and development of PTC and the correlation of BRAF(V600E) gene mutation and the clinicopathological characteristics of PTC. Finally, we briefly summarize some scientific achievements about tyrosine kinase inhibitors targeted for BRAF(V600E) gene and their clinical prospect in terms of translation medicine concept. In summary, BRAF(V600E) gene is expected to be a new molecular marker of PTC, which will take a new hope for individualized precise treatment for patients with PTC.

Loading Shanxi Provincial Tumor Hospital collaborators
Loading Shanxi Provincial Tumor Hospital collaborators