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Taiyuan, China

Shanxi Medical University is a university in Shanxi, People's Republic of China under the authority of the provincial government. It is the best medical university in Shanxi Province. Wikipedia.


Objective: To compare the synchronous primary endometrial and ovarian carcinomas with primary endometrial cancer with ovarian metastasis through analysis the general condition, clinical features, pathologic result, treatment and the prognosis of the two diseases. Methods:24 patients with synchronous primary endometrial and ovarian carcinomas and 27 patients with primary endometrial cancer with ovarian metastasis in Shanxi Cancer Hospital from January 2000 to January 2015 were collected. Results: There were statistical significance among age, menopause or not, clinical symptoms, ascites, vascular tumor emboli, tumor differentiation, lymph node metastasis and the prognosis between the two groups (all P < 0.05). The patients with synchronous primary endometrial and ovarian carcinomas were younger, had pelvic mass and stomachache, less ascites, no vascular tumor emboli, well tumor differentiation, no lymph node metastasis. They had better prognosis compared with patients with primary endometrial cancer with ovarian metastasis. Conclusions: Patients with synchronous primary endometrial and ovarian carcinomas are younger than patients with primary endometrial cancer with ovarian metastasis, and more early stage, the excessive treatment should be prevented. They have better prognosis compared with patients with primary endometrial cancer with ovarian metastasis. Source


Zhang J.,Shanxi Medical University
Cancer Research and Clinic | Year: 2014

Objective: To evaluate the clinical value of gemstone spectral imaging (GSI) in preliminary assessment of esophageal carcinoma pathology features. Methods: 58 patients were analyzed which were diagnosed with histological pathology as esophageal carcinoma underwent GSI enhanced scans before surgery. The iodine concentrations (IC) in the lesions were measured on the iodine-water based material-decomposition images. The results of IC value were evaluated retrospectively with different pathological grading, locations and pathological morphology according to the final pathologic findings. Results: 52 cases patients were squamous cell carcinoma and 6 patients were adenocarcinoma. The IC values were (14.75±4.24) mg/ml and (12.86±5.09) mg/ml. The IC value between the two different pathological types had not statistically difference (P = 0.35). The IC of different pathological grading: Well differentiation was (20.08±4.66)mg/ml, n = 19. Medium was (14.13±3.39) mg/ml, n = 25. Poor was(11.73±3.21) mg/ml, n = 14. The IC values between pathological grading had significant difference(P = 0.00). There were four different pathological morphology including medullar (n = 16), mushroom type (n = 21), ulcer (n = 13) and narrow type (n = 8). Their IC values respectively were (16.34±2.56) mg/ml, (18.70±3.03) mg/ml, (14.31±4.60) mg/ml and (11.18±2.09) mg/ml. The IC value between mushroom and narrow type had statistical difference (P = 0.04). The Other types had no statistically difference (P = 0.19). Conclusions: The results of this study demonstrate that GSI has a certain ability of pathologic stage of esophageal cancer. The GSI has a certain clinical value in guiding treatment and judging prognosis of esophageal carcinoma. Source


Wang J.G.,Shanxi Medical University
Cancer Research and Clinic | Year: 2014

Objective: To investigate the relationship between the expression level of deleted in liver cancer-1 (DLC-1) gene and colon cancer staging or lymph nodes metastatic ratio. Methods: Total 60 resection specimens were collected from colon cancer patients between September 2009 and September 2011, and 10 resection specimens from patients with trauma, colonic diverticulitis and colitis were used as the control. The DLC-1 mRNA level was measured with real time quantitative RT-PCR in colon cancer patients and the control group. TNM system was used for colon cancer staging. The linear correlation analysis was performed to determine the relationship between DLC-1 expression level and colon cancer staging or lymph nodes metastatic ratio. Results: The mRNA level of DLC-1 was significantly reduced in colon cancer tissues in comparison to that in adjacent normal tissues, while adjacent tissues showed significantly lower DLC-1 level than normal clone tissues. The expression of DLC-1 was negatively correlated with both colon cancer stage and the lymph nodes metastatic ratio (r = 0.46, P < 0.05). Conclusions: DLC-1 expression was negatively correlated with pathological stage and lymph node metastasis ratio, indicating a critical role of DLC-1 gene in colon cancer genesis, which provide a possible new direction for colon cancer research. Source


Autophagy is important in cells for removing damaged organelles, such as mitochondria. Insufficient autophagy plays a critical role in tissue injury and organ dysfunction under a variety of pathological conditions. However, the role of autophagy in nonlethal traumatic cardiac damage remains unclear. The aims of the present study were to investigate whether nonlethal mechanical trauma may result in the change of cardiomyocyte autophagy, and if so, to determine whether the changed myocardial autophagy may contribute to delayed cardiac dysfunction. Male adult rats were subjected to nonlethal traumatic injury, and cardiomyocyte autophagy, cardiac mitochondrial function, and cardiac function in isolated perfused hearts were detected. Direct mechanical traumatic injury was not observed in the heart within 24 h after trauma. However, cardiomyocyte autophagy gradually decreased and reached a minimal level 6 h after trauma. Cardiac mitochondrial dysfunction was observed by cardiac radionuclide imaging 6 h after trauma, and cardiac dysfunction was observed 24 h after trauma in the isolated perfused heart. These were reversed when autophagy was induced by administration of the autophagy inducer rapamycin 30 min before trauma. Our present study demonstrated for the first time that nonlethal traumatic injury caused decreased autophagy, and decreased autophagy may contribute to post-traumatic organ dysfunction. Though our study has some limitations, it strongly suggests that cardiac damage induced by nonlethal mechanical trauma can be detected by noninvasive radionuclide imaging, and induction of autophagy may be a novel strategy for reducing posttrauma multiple organ failure. Source


Objective: To analyze the clinical features, prognosis and its influence factors of pharyngeal lymphatic ring diffuse large B-cell lymphoma. Methods: 66 cases diagnosed with pharyngeal lymphatic ring diffuse large B-cell lymphoma were analyzed retrospectively, including 13 nasopharynx cases, 49 tonsil cases and 4 tongue root cases. The patients in I - II phases were mainly treated with chemotherapy plus involvement wild illuminate, and the patients in HI-IV phases were mainly treated with chemotherapy. Results: Most patients with pharyngeal lymphatic ring diffuse large B-cell lymphoma were in phase II, showing that neighboring organs were infiltrated, but rare systemic symptom, spleen were invaded and lactic acid dehydrogenase was increased. The overall survival rates of 3 and 5 years in patients with pharyngeal lymphatic ring diffuse large B-cell lymphoma were 77.9 % and 66.9 % respectively. The single-factor analysis indicated that the lactic acid dehydrogenase ≥ 248 U/L, the international prognostic index (IPI) score ≥1, and ECOG score≥2 were the adverse prognosis influence factors. The multiple-factor analysis showed that the IPI score ≥ 1 was related to poor prognosis of pharyngeal lymphatic ring diffuse large B-cell lymphoma. Conclusion: Pharyngeal lymphatic ring diffuse large B-cell lymphoma has unique clinical characteristics, and IPI score can influence the prognosis. Source

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