Zhang S.,Shanxi Medical University |
Zhang S.,Shanxi Key Laboratory of Otolaryngology Head and Neck Cancer |
Guo Y.,Shanxi Medical University |
Zhang C.,Shanxi Medical University |
And 9 more authors.
Cancer Investigation | Year: 2015
The pathogenesis of laryngeal cancer (LC) is unclear. Published data indicate that micro RNAs (miRNA) play an important role in the pathogenesis of cancer. This study aims to elucidate the role of miR-193b in the tumor tolerance of LC. High levels of miR-193b were detected in LC cells as well as in the culture supernatant. Interleukin (IL)-10-expressing Mos were detected in the LC tissue-derived single cells. Treating naïve Mos with a miR-193b induced expression of IL-10 in the Mos. Culturing the IL-10+ Mos with effector CD8+ T cells resulted in the suppression of CD8+ T-cell activities. Copyright © 2015 Informa Healthcare USA, Inc.