Shanxi Institute for Food and Drug Control

Taiyuan, China

Shanxi Institute for Food and Drug Control

Taiyuan, China
SEARCH FILTERS
Time filter
Source Type

Guo J.,Shenyang Pharmaceutical University | Guo J.,Shanxi Institute for Food and Drug Control | Wang J.,Shenyang Pharmaceutical University | Cai C.,Shenyang Pharmaceutical University | And 4 more authors.
AAPS PharmSciTech | Year: 2015

Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma efficiency in xenograft animal models after intratumoral injection, which was due to the undesirable initial burst release and the leakage of the particulate carriers from the injection site through the pinhole. In this paper, two categories of in situ-forming implants (ISFIs) for intratumoral injection, PLGA ISFIs and SAIB ISFIs, were systemically evaluated for their potentials for on solid tumor treatment via intratumoral injection. The in vitro drug release profiles of these two ISFIs were different due to the different sol–gel transition properties. The pharmacodynamics results revealed that SAIB ISFIs displayed obvious therapeutic efficiencies to melanoma, and multi-points injection of SASIB ISFIs displayed better efficiency than single-point injection. The different sol–gel transition properties and mechanism for PLGA ISFIs and SAIB ISFIs affected both the drug release and strongly impacted the pharmacokinetic parameters and pharmacodynamic effectiveness. Also, the adhesive property of SAIB to the local tissue could extend the retention and inhibit the leakage of the SAIB ISFIs, thus enhanced the anticancer effectiveness. Comparison of the various intratumoral injection systems, appropriate drug release profiles (lower initial burst and steady release) and good retention (minimum leakage from the injection site) would benefit to the antitumor effects of the intratumoral depots. © 2015, American Association of Pharmaceutical Scientists.


Yang X.,Shanxi University | Yang X.,Shanxi Cancer Institute | Zhang S.,Shanxi University | Ren L.,Shanxi Cancer Institute | And 2 more authors.
Journal of Pharmacy and Pharmacology | Year: 2013

Objective Chronic renal failure (CRF) is a progressive, life-threatening condition with limited treatment options. Cordyceps sinensis is a fungus that has nephroprotective effects, and Isaria felina (IF) is a fungus isolated from C. sinensis fruiting bodies. We evaluated IF efficacy using an adenine-induced CRF animal model. Methods Forty male Sprague-Dawley rats were divided into normal control (n = 8) and adenine groups (n = 32; 100 mg/kg for 30 days). The adenine group was subdivided into a model control group (n = 7), a positive control group (200 mg/kg Jinshuibao capsule (JSB; n = 8), and two IF groups (200 mg/kg, n = 8; 100 mg/kg, n = 8). After treatment for 30 days, animals were narcotized and abdominal aortic blood was analysed. Kidney functions were evaluated. Key findings Higher serum creatinine, blood urea nitrogen and uric acid levels, and lower creatinine clearance was observed in the model control group compared with JSB and IF groups (P < 0.05). Red blood cell count, haemoglobin and haematocrit levels in the 200 mg/kg IF group were higher than in the model control group (P < 0.05). Transforming growth factor-β1 mRNA expression in the model control group was higher than the normal control and 200 mg/kg IF groups (P < 0.05). Epidermal growth factor mRNA in the model control group was lower than in the normal control and both IF-treated groups (P < 0.05). Structural renal damage was observed in all adenine-treated rats, but was less severe in the JSB and IF groups. Conclusion IF may reverse the damaged kidney functions-induced with adenine in rats. © 2013 Royal Pharmaceutical Society.


Feng Y.-C.,National Institutes for Food and Drug Control | Yang X.-L.,Shanxi Institute for Food and Drug Control | Yang Z.-H.,Shanxi Institute for Food and Drug Control | Hu C.-Q.,National Institutes for Food and Drug Control
Journal of Chinese Pharmaceutical Sciences | Year: 2011

Four rapid spectral comparison methods are introduced in mobile labs. They are conformity test method, general correlation coefficient method, reverse correlation coefficient method and correlation coefficient method using characteristic spectral ranges. The first method is used for tracking the movements of drugs in the distribution channels; the second is used for quickly identify new counterfeit drugs; the last two are used to screen drugs illegally added in Traditional Chinese Medicine (TCM). The applicability of the four methods is evaluated with counterfeit and authentic drugs. Our results show that these methods can be quickly constructed and used to identify counterfeit drugs accurately. © 2011 Journal of Chinese Pharmaceutical Sciences, School of Pharmaceutical Sciences, Peking University.


Lian Y.-L.,Shanxi Institute for Food and Drug Control
Chinese Journal of New Drugs | Year: 2013

Objective: To establish a fingerprint determination method for the characterization of dihydroxydibutylether optical isomers and geometric isomers. Methods: The GC analysis was performed on an HP-CHIRAL-10B capillary chiral column with FID detector. The inlet temperature was set at 200°C. The detector temperature was set at 210°C. The column temperature was programmed from 100 to 200°C with a rate of 0.35°C·min-1 and kept at 200°C for 5 min. Results: The peaks of three isomers in component I, three isomers in component II, and two isomers in fraction III can be determined simultaneously by this method. Conclusion: The method is simple, accurate, and comprehensive for the quality control and evaluation of dihydroxydibutylether optical isomers and geometric isomers.


PubMed | Shanxi Medical University and Shanxi Institute for Food and Drug Control
Type: Journal Article | Journal: Integrative cancer therapies | Year: 2016

Bladder cancer is a common malignant tumor with a very high recurrence rate after surgery. Intravesical instillation can help clear up the residual tumor cells after surgery and thereby reduce the recurrence rate.To establish a bladder tumor transplantation animal model and to evaluate the inhibitory effects of a novel perfusate, Su Funing Lotion (SFN), on bladder tumor.SFN was compared with several commonly used chemotherapy drugs, including mitomycin (MMC) and pirarubicin (THP) for anticancer effects on the bladder cancer cell lines T24, BTT, and BIU-87 and SFN half inhibitory concentrations (IC50) were determined after 48 hours of treatment. In addition, bladder cancer orthotopic transplantation tumor models were established in BALB/C nude mice and T739 mice, and SFN anticancer effects were assessed in vivo, with normal saline and MMC as negative and positive controls, respectively.SFN, MMC, and THP were all lethal to bladder cancer cells, in vitro, with SFN and THP significantly superior to MMC. IC50 values for SFN were 13.22, 11.22, and 12.5 g/mL on T24, BTT, and BIU-87 cells, respectively. In vivo, SFN significantly reduced the mouse bladder wet weight and prolonged the animal survival compared with controls (P < .05), suggesting that SFN significantly inhibited T24/BTT cell growth in mice.SFN inhibited the bladder cancer cell proliferation in vitro and in vivo and significantly prolonged the survival of mice with bladder cancer xenografts, indicating that SFN could be used as a perfusate after surgery for removal of residual bladder cancers cells.


Yang X.-L.,Shanxi Institute for Food and Drug Control | Li C.,Shanxi Institute for Food and Drug Control | Li H.,Shanxi Institute for Food and Drug Control
Chinese Journal of Pharmaceutical Biotechnology | Year: 2015

To confirm whether the methods of national food safety standard for different functional health foods were appropriate and scientific by verification. According to the Chinese Pharmacopoeia 2010 edition was validated the microbiological test method of 6 types in 27 kinds of health foods. There were different level missed detection problem, about 78% when were used the methods of national food safety standard to detect pathogenic bacteria of health food. The inhibitory effect of health food on Staphylococcus aureus was the strongest, and then Shigella and Streptococcus hemolyticus and Salmonella was the last. The medium dilution method (1:20) could effectively remove the bacteriostatic action to improve the accuracy when health food had bacteriostatic action. If methods of national food safety standard were directly used to detect pathogenic bacteria of health food the risk to be missed affected the accuracy of results. The problem of microbial test method validation for health food should be concerned. © 2015, Editorial Board of Pharmaceutical Biotechnology. All right reserved.


Chen H.,PLA Fourth Military Medical University | Wang Q.F.,PLA Fourth Military Medical University | Sun X.L.,PLA Fourth Military Medical University | Luo J.,shanxi Institute for Food and Drug Control | Jiang R.,PLA Fourth Military Medical University
Mendeleev Communications | Year: 2010

Cinchona alkaloid ester derivatives were adopted to asymmetric dihydroxylation and asymmetric aminohydroxylation reactions in excellent yields and enantiomeric excesses. © 2010.


Chen Z.,Shanxi University | Chen W.,Shanxi Institute for Food and Drug Control | Li C.,University of Melbourne | Pu Y.,Sichuan Bioenvironmental Engineering Co. Chengdu | Sun H.,Shanxi University
Science of the Total Environment | Year: 2016

Erosion of denuded steep rocky slopes causes increasing losses of nitrogen and phosphorus, which is a severe problem in rocky slope protection. Thus, it is important to determine the appropriate materials that can reduce the erodibility and losses of nitrogen and phosphorus of the soil. In this paper, twenty-seven simulated rainfall events were carried out in a greenhouse, in which the substrate material was artificial soil; nine types of anionic polyacrylamide (PAM) were studied, which consisted of three molecular weight (6, 12, and 18 Mg mol-1) and three charge density (10, 20, and 30%) formulations in a 3 by 3 factorial design. The results showed that: (1) Polyacrylamide application reduced total nitrogen losses by 35.3% to 50.0% and total phosphorus losses by 34.9% to 48.0% relative to the control group. (2) The losses of total nitrogen and total phosphorus had significant correlation with the molecular weight. Besides, the losses of total phosphorus, particulate-bound phosphorus and inorganic nitrogen (NH4-N) were significantly correlated with their molecular weight and charge density. However, the losses of dissolved organic nitrogen, inorganic nitrogen (NO3-N), dissolved organic phosphorus, inorganic phosphorus (PO4-P) were non-significantly correlated with molecular weight and charge density. (3) Particulate-bound nitrogen and phosphorus were responsible for the losses of nitrogen and phosphorus during runoff events, where particulate-bound nitrogen made up 71.7% to 73.2% of total nitrogen losses, and particulate-bound phosphorus made up 82.3% to 85.2% of total phosphorus losses. (4) Polyacrylamide treatments increased water-stable aggregates content by 32.3% to 59.1%, total porosity by 11.3% to 49.0%, final infiltrative rate by 41.3% to 72.5%, and reduced soil erosion by 18.9% to 39.8% compared with the control group. Overall, the results of this study indicated that polyacrylamide application in the steep rocky slope stabilization projects could significantly reduce nutrient losses and soil erosion of substrate material. © 2016 Elsevier B.V.


PubMed | University of Melbourne, Shanxi University and Shanxi Institute for Food and Drug Control
Type: | Journal: The Science of the total environment | Year: 2016

Erosion of denuded steep rocky slopes causes increasing losses of nitrogen and phosphorus, which is a severe problem in rocky slope protection. Thus, it is important to determine the appropriate materials that can reduce the erodibility and losses of nitrogen and phosphorus of the soil. In this paper, twenty-seven simulated rainfall events were carried out in a greenhouse, in which the substrate material was artificial soil; nine types of anionic polyacrylamide (PAM) were studied, which consisted of three molecular weight (6, 12, and 18 Mg mol(-1)) and three charge density (10, 20, and 30%) formulations in a 3 by 3 factorial design. The results showed that: (1) Polyacrylamide application reduced total nitrogen losses by 35.3% to 50.0% and total phosphorus losses by 34.9% to 48.0% relative to the control group. (2) The losses of total nitrogen and total phosphorus had significant correlation with the molecular weight. Besides, the losses of total phosphorus, particulate-bound phosphorus and inorganic nitrogen (NH4-N) were significantly correlated with their molecular weight and charge density. However, the losses of dissolved organic nitrogen, inorganic nitrogen (NO3-N), dissolved organic phosphorus, inorganic phosphorus (PO4-P) were non-significantly correlated with molecular weight and charge density. (3) Particulate-bound nitrogen and phosphorus were responsible for the losses of nitrogen and phosphorus during runoff events, where particulate-bound nitrogen made up 71.7% to 73.2% of total nitrogen losses, and particulate-bound phosphorus made up 82.3% to 85.2% of total phosphorus losses. (4) Polyacrylamide treatments increased water-stable aggregates content by 32.3% to 59.1%, total porosity by 11.3% to 49.0%, final infiltrative rate by 41.3% to 72.5%, and reduced soil erosion by 18.9% to 39.8% compared with the control group. Overall, the results of this study indicated that polyacrylamide application in the steep rocky slope stabilization projects could significantly reduce nutrient losses and soil erosion of substrate material.


PubMed | Yale University, Nanjing University of Technology, Nanjing Emory Biotechnology Company and Shanxi Institute for Food and Drug Control
Type: | Journal: Chemosphere | Year: 2016

2,4-Dichlorophenoxyacetic acid (2,4-D) is widely used in agriculture as herbicide/pesticide, plantgrowth regulator and fruit preservative agent. It progressively accumulates in the environment including surface water, air and soil. It could be detected in human food and urine, which poses greatrisk to the living organisms. In the present study, we investigated the developmental toxicity of 2,4-D on zebrafish (Danio rerio) embryo. 2,4-D exposure significantly decreased both the survival rate(LC

Loading Shanxi Institute for Food and Drug Control collaborators
Loading Shanxi Institute for Food and Drug Control collaborators