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Chen H.,PLA Fourth Military Medical University | Luo J.,shanxi Institute for Drug and Food Control | Li X.,PLA Fourth Military Medical University | Liu P.,PLA Fourth Military Medical University | Jiang R.,PLA Fourth Military Medical University
Journal of Radioanalytical and Nuclear Chemistry | Year: 2013

Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide (Tempol) to phenol with the aim of improving radioprotective activity. The radical scavenging activities of four Tempol-phenol conjugates were evaluated in L-02 and MCF-7 cells survival assays. A differential protection in normal cells as compared to tumor cells was confirmed. In addition, the protective effect of these compounds was demonstrated in a greater increase in peripheral WBC, ANC, AMC, and platelet counts in an in vivo rat model. It might be possible to develop them into a possible agent for radical injury. © 2013 Akadémiai Kiadó, Budapest, Hungary. Source

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