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Taiyuan, China

Qiao Q.-H.,The Peoples Hospital of Yushe County | Tang G.-L.,Shanxi Eye Hospital
International Eye Science

AIM: To determine the value of 24-hour intraocular pressure (IOP) monitoring in routine clinical practice of suspects of glaucoma. METHODS: Fifty-one suspects of glaucoma (51 eyes) were selected for 24-hour IOP monitoring without any anti-glaucoma therapy. Goldmann tonometer was used for 24-hour IOP measurement. RESULTS: In all of 51 eyes, there were only 21 (41.2%) eyes with IOP kept in normal range and IOP variation amplitude under 6mmHg, 30 eyes (58.8%) were with large diurnal fluctuations in IOP or the peak IOP up to 21mmHg. The IOP of the 7 eyes were with intraocular hypertension only at night, with highest IOP of 54mmHg, with daytime IOP relieved to normal range. The 24-hour IOP monitoring were higher than of the daytime IOP measurement (P<0.01). CONCLUSION: Compared with the daytime IOP measurement, the 24-hour IOP monitoring could identify diurnal IOP and/or IOP spikes better. Copyright 2013 by the IJO Press. Source

Li X.-N.,Taiyuan University of Technology | Wang X.-J.,Taiyuan University of Technology | He R.,Shanxi Eye Hospital | Chen W.-Y.,Taiyuan University of Technology
Yiyong Shengwu Lixue/Journal of Medical Biomechanics

Objective: To investigate the effect of different mechanical environment (in vivo and in vitro) on expression of basic fibroblast growth factor (bFGF) and explore the role of mechanical stimulation in corneal tissue repair after laser assisted in situ keratomileusis (LASIK) surgery. Methods: Animal models by LASIK surgery were established to keep the corneas under different mechanical environment. The experimental animals were killed at the first week or the first month after LASIK surgery to obtain the corneas. In addition, the primary corneal fibroblasts were subjected to cyclic mechanical stretch (0.1 Hz; 5%, 10%, 15% stretch; 6 h or 24 h) using Flexcell 4000 tension system. Expression of bFGF was determined by ELISA method. Results: At the first week after LASIK surgery, expression of bFGF was increased significantly in 30% group (residual stroma bed accounting for 30% of the whole cornea), as compared with the control group (P<0.05), and then it was decreased to the normal level in all groups at the first month after LASIK surgery. Analysis on the same surgery method at different time showed that there were significant differences only in 30% group at the first week and month (P<0.05). Cyclic stretch experiment in vitro indicated that bFGF expression in 15% stretch group was significantly increased after 6 h than that in the control group (P<0.05), with a significant decrease after 24 h (P<0.05). Conclusions: Mechanical stimulation can regulate bFGF expression of corneal tissues and corneal frbroblasts, and bFGF plays a positive role in the early corneal tissue repair after LASIK surgery. Source

Dong Z.,Capital Medical University | Wang N.-L.,Capital Medical University | Li J.-H.,Shanxi Eye Hospital
Chinese Medical Journal

Background The TetraFlex accommodating intraocular lens (IOL) was designed to supply the patients both satisfied far and near vision after cataract surgery. So we need to evaluate the safety, distance and near visual acuity, subjective accommodation and IOL mobility with the TetraFlex accommodating IOL implantation. Methods Fifty eyes of 42 study-eligible cataract patients, who gave informed consent at a single eye clinic in China over a 10-month period, underwent phacoemulsification with TetraFlex IOL implantation. At three months postoperation, uncorrected visual acuities (UCVA), best corrected visual acuities (BCVA), distance-corrected near visual acuities (DCNVA), subjective accommodation using the defocus method, and pilocarpine-induced IOL mobility were measured. Results No postoperative complications were noted in the study. Three months postoperation UCVA and BCVA were 20/40 or bettter in 82% (41/50) and 92% (46/50) of eyes, respectively; 66% (33/50) of the eyes had DCNVA of Jager (J) 4 or better at 3 months. In addition, the mean subjective accommodation was (0.94±0.61) diopters (D) (range from 0.50 to 1.50 D) and pilocarpine-induced IOL mobility was (337±124) μm (range from 121 to 501 μm) with the TetraFlex. High relationship (r2=0.901, P <0.01) was found between these two measurements. Conclusion Implantation of the TetraFlex is safe and leads to excellent uncorrected distance vision and good uncorrected near vision. Source

Hou G.-P.,Shanxi Eye Hospital
International Journal of Ophthalmology

AIM: To study the method and effect of using Nd:YAG laser in treating posterior capsular opacities after mydriasis. METHODS: After mydriasis posterior capsular opacities treated with Nd:YAG laser posterior capsulotomy. RESULTS: The success rate of the operation was 99.8%. The best corrected visual acuity (BCVA) was improved significantly in 97.2% cases (BCVA ≥ 0.4) by Nd:YAG laser therapy after mydriasis. CONCLUSION: After mydriasis, Nd: YAG laser posterior capsulotomy is a kind of effective, safe, simple and low-rate complication technique in treating after cataract. Source

Zhao J.-M.,Shanxi Eye Hospital
International Journal of Ophthalmology

AIM: To evaluate the effect and safety of morning vs evening once daily of fixed combinations latanoprost/timolol maleate therapy in primary open angle glaucoma or in ocular hypertensive patients. METHODS: This study was prospective, observational clinial research. All ophthalmology examinations and 24 hours IOP testing were performed at the beginning of the study of latanoprost/timolol maleate. At 1 month follow-up, 24 hours IOP was tested and recorded the results and side effects. One week after stopping treatment, this was then changed to evening dosing once daily with fixed combinations of latanoprost/timolol maleate. After 1 month follow-up, 24 hours IOP was tested, the results and side effects were recorded. The IOP and side effects in two groups were then compared. RESULTS: Thirty-two patients completed this study. There was a significant reduction at each time point in the 24-hour diurnal curve of both morning (17.3 ± 3.1mmHg) and evening (17.1 ± 2.7mmHg) dosed patients, compared to the baseline IOP (21.1 ± 3.3mmHg) (P < 0.01). When the morning and evening dosing groups were compared directly, the 6:00 time point was statistically lower with evening dosing (16.4 ± 2.3mmHg) vs morning dosing (17.9 ± 2.8mmHg) (P < 0.05). A trend was observed, which indicated greater daytime reduction with night-time dosing, whereas morning dosing tended to give lower night-time pressure. There was a significantly lower mean range of diurnal pressure with evening (3.6 ± 1.6mmHg) vs morning (4.4 ± 1.6mmHg) dosing (P < 0.05). There was no significant difference between two groups of side effects (P> 005). CONCLUSION: This study suggests that fixed combinations latanoprost/timolol maleate both given once daily in the morning and evening can effectively reduce the IOP for the 24-hour diurnal curve and are well tolerated with few side effects. There is a significantly stable 24 hour IOP lowering in evening dosed fixed combinations of latanoprost/timolol maleate. Source

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