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Taiyuan, China

Yin W.-H.,Peking Union Medical College | Lu B.,Peking Union Medical College | Gao J.-B.,Zhengzhou University | Li P.-L.,Liaoning Medical University | And 8 more authors.
Journal of Cardiovascular Computed Tomography | Year: 2015

Background: Both low tube voltage and sinogram-affirmed iterative reconstruction (IR) techniques hold promise to decrease radiation dose at coronary CT angiography (CCTA). The increased iodine contrast at low tube voltage allows for minimizing iodine load. Objective: To assess the effect of reduced x-ray tube voltage, low iodine concentration contrast medium and IR on image quality and radiation dose at CCTA. Methods: Two hundred thirty-one consecutive patients with suspected coronary artery disease were enrolled in this prospective, multicenter trial and randomized to 1 of 2 dual-source CCTA protocols: 120-kVp with 370mgI/mL iopromide or iopamidol (n= 116; 44 women; 55.3 ± 9.8years) or 100kVp with 270mgI/mL iodixanol (n= 115; 48 women; 54.2 ± 10.4years). Reconstruction was performed with filtered back projection and IR.Attenuation, image noise, signal-to-noise ratio, and contrast-to-noise ratio were measured and image quality scored. Size-specific dose estimates and effective doses were calculated. Results: There were no significant differences in mean arterial attenuation (406.6 ± 76.7 vs 409.7 ± 65.2 Hounsfield units; P= .739), image noise (18.7 ± 3.8 vs 17.9 ± 3.4 Hounsfield units; P= .138), signal-to-noise ratio (22.5 ± 5.4 vs 23.7 ± 6.1; P= .126), contrast-to-noise ratio (17.5 ± 5.5 vs 18.3 ± 6.1; P= .286), or image quality scores (4.1 ± 0.9 vs 4.0 ± 0.9; P>.05) between 120-kVp filtered back projection-reconstructed and 100-kVp IR-reconstructed series. Mean iodine dose was 26.5% lower (18.3 ± 0.5 vs 24.9 ± 0.9g; P<.0001), mean size-specific dose estimate was 35.1% lower (17.9 ± 6.6 vs 27.5 ± 8.2mGy; P< .0001), and effective dose was 34.9% lower (2.3 ± 1.0 vs 3.5 ± 1.1mSv; P < .0001) with the 100kVp compared with the 120-kVp protocol, respectively. Conclusion: Using low x-ray tube voltage and IR allows for decreasing the iodine load and effective radiation dose at CCTA while maintaining image quality. © 2015 Society of Cardiovascular Computed Tomography.

Acute myeloid leukemia (AML) is a disease of the elderly. Treating acute myeloid leukemia in the elderly is the highlight in the 56th American Society of Hematology (ASH) annual meeting. The question of which elderly patients with AML benefit from conventional intensive chemotherapy versus hypomethylating therapy or novel agent remains uncertain. This article reviews the latest research presented at the 56th ASH annual meeting on the elderly AML. © 2015 by the Chinese Medical Association.

Liangming M.,Shanxi Dayi Hospital
Journal of Leukemia and Lymphoma | Year: 2015

Acute lymphoblastic leukemia (ALL) is a heterogeneous disease affected by many factors, including age, immunologic subtype, and clinical, genetic and molecular features. Improved tools can identify patients in remission based on morphology but those with active disease based on molecular biology or immunophenotype (minimal residual disease). B-cell antigen panels, clone-specific immunoglobulins,or T-cell receptor rearrangements is used to detect positivity at thresholds at least. There are 13 ALL clinical related abstracts (poster) in the 19th European Hematology Association annual congress which reflected recent progress of research ALL. © 2015, Editorial Board of Journal of Leukemia and Lymphoma. All rights reserved.

Hu W.-Q.,Shanxi Medical University | Fang M.,Hubei University | Zhao H.-L.,Shanxi Dayi Hospital | Yan S.-G.,Changzhi Medical College | And 5 more authors.
Biomaterials | Year: 2014

In tumor tissues, cancer cells, tumor infiltrating macrophages and tumor neo-vessels in close spatial vicinity with one another form tumor invasion unit, which is a biologically important tumor microenvironment of metastasis to facilitate cancer invasion and metastasis. Establishing an in situ molecular imaging technology to simultaneously reveal these three components is essential for the in-depth investigation of tumor invasion unit. In this report, we have developed a computer-aided algorithm by quantum dots (QDs)-based multiplexed molecular imaging technique for such purpose. A series of studies on gastric cancer tumor tissues demonstrated that the tumor invasion unit was correlated with major unfavorable pathological features and worse clinical outcomes, which illustrated the significantly negative impacts and predictive power of tumor invasion unit on patient overall survival. This study confirmed the technical advantages of QDs-based in situ and simultaneous molecular imaging of key cancer molecules to gain deeper insights into the biology of cancer invasion. © 2014 Elsevier Ltd.

Rosenthal V.D.,International Nosocomial Infection Control Consortium | Pawar M.,Pushpanjali Crosslay Hospital | Leblebicioglu H.,Ondokuz Mayis University | Navoa-Ng J.A.,Rush University Medical Center | And 14 more authors.
Infection Control and Hospital Epidemiology | Year: 2013

objective. To assess the feasibility and effectiveness of the International Nosocomial Infection Control Consortium (INICC) multi- dimensional hand hygiene approach in 19 limited-resource countries and to analyze predictors of poor hand hygiene compliance. design. An observational, prospective, cohort, interventional, before-and-after study from April 1999 through December 2011. The study was divided into 2 periods: a 3-month baseline period and a 7-year follow-up period. setting. Ninety-nine intensive care unit (ICU) members of the INICC in Argentina, Brazil, China, Colombia, Costa Rica, Cuba, El Salvador, Greece, India, Lebanon, Lithuania, Macedonia, Mexico, Pakistan, Panama, Peru, Philippines, Poland, and Turkey. participants. Healthcare workers at 99 ICU members of the INICC. methods. A multidimensional hand hygiene approach was used, including (1) administrative support, (2) supplies availability, (3) education and training, (4) reminders in the workplace, (5) process surveillance, and (6) performance feedback. Observations were made for hand hygiene compliance in each ICU, during randomly selected 30-minute periods. results. A total of 149,727 opportunities for hand hygiene were observed. Overall hand hygiene compliance increased from 48.3% to 71.4% (P <.01). Univariate analysis indicated that several variables were significantly associated with poor hand hygiene compliance, including males versus females (63% vs 70%; P <.001), physicians versus nurses (62% vs 72%; P <.001), and adult versus neonatal ICUs (67% vs 81%; P <.001), among others. conclusions. Adherence to hand hygiene increased by 48% with the INICC approach. Specific programs directed to improve hand hygiene for variables found to be predictors of poor hand hygiene compliance should be implemented. © 2013 by The Society for Healthcare Epidemiology of America. All rights reserved.

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