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Li Z.-J.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | Luo X.-H.,Capital Medical University
Chinese Journal of Medical Imaging Technology | Year: 2012

Objective: To discuss the longitudinal strain (LS) of myocardium in the patients with type 2 diabetes mellitus (DM) based on the ventricular-arterial coupling. Methods: Eighty patients with DM were divided into normal left ventricular ejection fraction (EF) group (DMN group, EF≥50%, n=40) and abnormal EF group (DMA group, EF<50%, n=40). At the same time, 42 healthy volunteers were selected as the controls. The stroke volume was measured and then stroke works (SW), rate-pressure product (RPP), systemic vascular resistance index (SVRI) and arterial elastance index (Ea) were calculated, respectively. LS of myocardial segments including base (SL BA), papillary muscle (SL PM)and apex (SL AP) were analyzed using two-dimensional speckle tracking imaging, and the mean values of 6 segments at the same level were regarded as strain value at this level. Results: Compared with contral group and DMN group, RPP, Ea and SVRI in DMA group had statistical difference (all P<0.05). There were statistical differences of SL BA, SL PM and SL AP among DMN, DMA and control groups (all P<0.01). SL BA, SL PM and SL AP were correlated positively with Ea, SVRI, EF and FS (P<0.01), and had negative correlation with SW and RPP (all P<0.01). For comparison of DMN and control group, ROC analysis showed that the area under ROC curve of SL BA, SL PM and SL AP was 0.857, 0.862 and 0.832, respectively (all P>0.05). For comparison of DMA and DMN group, the ROC analysis indicated that the area under ROC curve of SL BA, SL PM and SL AP was 0.720, 0.782 and 0.942. Conclusion: For patients with DM, ventricular-arterial coupling and LS decrease in synchronism. Ventricular-arterial uncoupling, LS would be asynchronous, power decrease and oxygen increase.

Huang X.,Shanxi Medical University | Kang X.,Shanxi Medical University | Xue J.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | Kang C.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: The purpose of this study is to evaluate the intima-media thickness (IMT) and arterial elasticity of the common carotid artery (CCA) in patients with cerebral small vessel disease (SVD) by applying radiofrequency (RF) ultrasound technology. Methods: Fifty SVD subjects (SVD group) and fiftythree matched controls (Control group) were enrolled in the study. Structural and functional changes in the common carotid arterial wall were investigated by quality intimamedia thickness (QIMT) and quanlity arterial stiffness (QAS) with a Mylab Twice ultrasound instrument. The vessel related variables between these two groups were analyzed. Results: There was a significant higher value of CCA-IMT in SVD group than that in control group (P<0.01). Pulse wave velocity (PWV), stiffness coefficient (α) and stiffness index (β) were remarkably greater (P<0.01) while compliance coefficient (CC) decreased significantly (P<0.01) in the SVD group than control group. Furthermore, significant difference was found on IMT between left and right CCA in SVD (P<0.01) and control group (P<0.01) while no significant difference was found on CC, α, β and PWV between left and right CCA in SVD (P>0.05) and control group (P>0.05). Conclusions: Decreased arterial elasticity of the CCA in patients with SVD compared with normal subjects. Ultrasound RF technology can be used to noninvasively and quantitatively detect the change in the structure and function of the CCA in SVD subjects for evaluating preclinical atherosclerosis. © 2015, E-Century Publishing Corporation. All rights reserved.

Wang J.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | Kang C.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | Feng T.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | Xue J.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | And 4 more authors.
Zeitschrift fur Medizinische Physik | Year: 2013

The purpose of this study was to investigate the effects of ultrasonic instrument gain, transducer frequency, and depth on the color variety and color filling of radiofrequency ultrasonic local estimators (RULES) images which indicated specific physical representation of liquid-containing lesions in order to find the optimal settings for the clinical application of RULES in liquid-containing lesions. Changing the ultrasonic instrument gain, transducer frequency, and depth affected the color filling and color variety of 21 pathologically-confirmed liquid-containing lesion images analyzed by RULES. Blue colored fill dominated the RULES images to represent the liquid-containing lesions. A frequency of 12.5. MHz led to red and green colors along the inner edges of the liquid-containing lesions. Changing the gain resulted in significantly different blue colored filling that was highest when the gain was 90 to 100. Changing the frequency also significantly changed the blue color filling, with the highest filling occurring at 12.5. MHz. Changing the depth did not affect the blue color filling. The liquid components of the lesions may be identified by their characteristic manifestations in RULES, where color variety is affected by transducer frequency and blue color filling which represent liquid-containing lesions in RULES images is affected by frequency and gain. © 2012.

Yang L.,Sun Yat Sen University | Yang L.,Shanxi Academy of Medical science and Shanxi Dayi Hospital | Cai X.,Sun Yat Sen University | Zhou J.,Sun Yat Sen University | And 6 more authors.
PLoS ONE | Year: 2013

The intracellular concentration of chloride ([Cl-]i) determines the strength and polarity of GABA neurotransmission. STE20/SPS1-related proline/alanine-rich kinase (SPAK) is known as an indirect regulator of [Cl-]i for its activation of Na-K-2 Cl-co-transporters (NKCC) and inhibition of K-Cl-co-transporters (KCC) in many organs. NKCC1 or KCC2 expression changes have been demonstrated previously in the hippocampal neurons of mice with pilocarpine-induced status epilepticus (PISE). However, it remains unclear whether SPAK modulates [Cl-]i via NKCC1 or KCC2 in the brain. Also, there are no data clearly characterizing SPAK expression in cortical or hippocampal neurons or confirming an association between SPAK and epilepsy. In the present study, we examined SPAK expression and co-expression with NKCC1 and KCC2 in the hippocampal neurons of mice with PISE, and we investigated alterations in SPAK expression in the hippocampus of such mice. Significant increases in SPAK mRNA and protein levels were detected during various stages of PISE in the PISE mice in comparison to levels in age-matched sham (control) and blank treatment (control) mice. SPAK and NKCC1 expression increased in vitro, while KCC2 was down-regulated in hippocampal neurons following hypoxic conditioning. However, SPAK overexpression did not influence the expression levels of NKCC1 or KCC2. Using co-immunoprecipitation, we determined that the intensity of interaction between SPAK and NKCC1 and between SPAK and KCC2 increased markedly after oxygen-deprivation, whereas SPAK overexpression strengthened the relationships. The [Cl-]i of hippocampal neurons changed in a corresponding manner under the different conditions. Our data suggests that SPAK is involved in the plasticity of GABA signaling function in acquired epilepsy via adjustment of [Cl-]i in hippocampal neurons. © 2013 Yang et al.

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